MuScle-logoMuScle - Molecule ID B0503

geneAKR1C3, DDH1, HSD17B5
nameAldo-keto reductase family 1 member C3
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AK1C3_HUMANP42330ENSG00000196139|ENSG000002656858644Hs.78183603966

Functions and classifications

GOC:cytosol, C:nucleus, F:15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity, F:alditol:NADP+ 1-oxidoreductase activity, F:androsterone dehydrogenase activity, F:delta4-3-oxosteroid 5beta-reductase activity, F:dihydrotestosterone 17-beta-dehydrogenase activity, F:geranylgeranyl reductase activity, F:indanol dehydrogenase activity, F:ketoreductase activity, F:ketosteroid monooxygenase activity, F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor, F:phenanthrene 9,10-monooxygenase activity, F:prostaglandin D2 11-ketoreductase activity, F:prostaglandin F receptor activity, F:prostaglandin-F synthase activity, F:retinal dehydrogenase activity, F:retinol dehydrogenase activity, F:testosterone 17-beta-dehydrogenase (NADP+) activity, F:testosterone dehydrogenase (NAD+) activity, F:trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity, P:cellular response to cadmium ion, P:cellular response to calcium ion, P:cellular response to corticosteroid stimulus, P:cellular response to jasmonic acid stimulus, P:cellular response to prostaglandin stimulus, P:cellular response to reactive oxygen species, P:cellular response to starvation, P:cyclooxygenase pathway, P:daunorubicin metabolic process, P:doxorubicin metabolic process, P:farnesol catabolic process, P:keratinocyte differentiation, P:male gonad development, P:multicellular organismal macromolecule metabolic process, P:negative regulation of retinoic acid biosynthetic process, P:phototransduction, visible light, P:positive regulation of cell proliferation, P:positive regulation of endothelial cell apoptotic process, P:positive regulation of protein kinase B signaling, P:positive regulation of reactive oxygen species metabolic process, P:progesterone metabolic process, P:protein import into nucleus, translocation, P:regulation of retinoic acid receptor signaling pathway, P:regulation of testosterone biosynthetic process, P:renal absorption, P:response to nutrient, P:retinal metabolic process, P:testosterone biosynthetic process, F:oxidoreductase activity, "C:cytoplasm, F:androsterone dehydrogenase (A-specific) activity, F:oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor, P:positive regulation of protein kinase B signaling cascade, P:prostaglandin metabolic process
UniProt3D-structure, Complete proteome, Cytoplasm, NAD, NADP, Oxidoreductase, Polymorphism, Reference proteome
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)1.521.22E-0220136355
Exp22252466AHomo sapiens13BloodCD34+ HPCRRMS_SPMS (Multiple sclerosis)1.220.038331922252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)16.223.15E-1622252466

Compile date 09-07-2016© MuScle project