MuScle-logoMuScle - Molecule ID B0501

geneAKR1C1, DDH, DDH1
nameAldo-keto reductase family 1 member C1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AK1C1_HUMANQ04828ENSG00000187134|ENSG000002665921645Hs.460260600449

Functions and classifications

GOC:cytosol, F:17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity, F:alditol:NADP+ 1-oxidoreductase activity, F:androsterone dehydrogenase (B-specific) activity, F:bile acid binding, F:indanol dehydrogenase activity, F:ketosteroid monooxygenase activity, F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor, F:phenanthrene 9,10-monooxygenase activity, F:trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity, P:bile acid and bile salt transport, P:bile acid metabolic process, P:cellular response to jasmonic acid stimulus, P:cholesterol homeostasis, P:daunorubicin metabolic process, P:doxorubicin metabolic process, P:intestinal cholesterol absorption, P:phototransduction, visible light, P:progesterone metabolic process, P:protein homooligomerization, P:response to organophosphorus, P:retinal metabolic process, P:xenobiotic metabolic process, F:oxidoreductase activity, F:oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
UniProt3D-structure, Complete proteome, Cytoplasm, Direct protein sequencing, NADP, Oxidoreductase, Polymorphism, Reference proteome
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)0.691.95E-0220136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)1.262.76E-0220136355
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_24_month_follow-up) (Multiple sclerosis)1.170.024186821886806
Exp22252466AHomo sapiens13BloodCD34+ HPCRRMS_SPMS (Multiple sclerosis)0.520.022256422252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)2.255.34E-0522252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)2.711.09E-0822252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)5.905.41E-0822252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)7.168.81E-1022252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)0.943.63E-0223895517

Compile date 09-07-2016© MuScle project