MuScle-logoMuScle - Molecule ID B0488

geneAIM2
nameInterferon-inducible protein AIM2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AIM2_HUMANO14862ENSG000001635689447Hs.733411604578

Functions and classifications

GOC:AIM2 inflammasome complex, C:cytosol, C:mitochondrion, C:nucleus, F:double-stranded DNA binding, P:activation of innate immune response, P:apoptotic process, P:cellular response to drug, P:cellular response to interferon-beta, P:inflammatory response, P:innate immune response, P:interleukin-1 beta secretion, P:negative regulation of NF-kappaB transcription factor activity, P:nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway, P:positive regulation of cysteine-type endopeptidase activity, P:positive regulation of defense response to virus by host, P:positive regulation of interleukin-1 beta secretion, P:positive regulation of NF-kappaB transcription factor activity, P:positive regulation of protein oligomerization, P:pyroptosis, P:tumor necrosis factor-mediated signaling pathway, C:AIM2 inflammasome complex, P:positive regulation of interleukin-1 beta production
UniProt3D-structure, Apoptosis, Complete proteome, Cytoplasm, DNA-binding, Immunity, Inflammatory response, Innate immunity, Nucleus, Polymorphism, Reference proteome, Tumor suppressor
PADBSIG: signalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)1.231.09E-0220136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)1.210.0127203720136355
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_12_month_follow-up) (Multiple sclerosis)2.000.0075338221886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_24_month_follow-up) (Multiple sclerosis)1.670.015667121886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)3.254.28E-0621886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1b_3_month_follow-up) (Multiple sclerosis)1.600.0492965821886806
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.687.22E-0422021740
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.166.21E-1122252466
Exp22491253Homo sapiens7Blood RRMS_(High_Sema4A) (Multiple sclerosis)0.400.0308742122491253

Compile date 09-07-2016© MuScle project