MuScle-logoMuScle - Molecule ID B0478

geneAICDA, AID
nameSingle-stranded DNA cytosine deaminase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AICDA_HUMANQ9GZX7ENSG0000011173257379Hs.149342605257, 605258

Functions and classifications

GOC:cytoplasm, C:nucleus, F:cytidine deaminase activity, F:zinc ion binding, P:B cell differentiation, P:cellular response to lipopolysaccharide, P:DNA demethylation, P:isotype switching, P:mRNA processing, P:negative regulation of methylation-dependent chromatin silencing, P:somatic hypermutation of immunoglobulin genes, "F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines, P:metabolic process", F:metal ion binding, P:somatic diversification of immunoglobulins, F:zinc ion binding"
UniProtAlternative splicing, Complete proteome, Cytoplasm, Disease mutation, Hydrolase, Metal-binding, mRNA processing, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Zinc
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.884.28E-0222252466
Exp22491253Homo sapiens7Blood RRMS_(High_Sema4A) (Multiple sclerosis)0.130.0238848122491253
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)0.952.32E-0223895517

Compile date 09-07-2016© MuScle project