MuScle-logoMuScle - Molecule ID B0467

geneAGTR1, AGTR1A, AGTR1B
nameType-1 angiotensin II receptor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AGTR1_HUMANP30556ENSG00000144891185Hs.477887106165, 267430

Functions and classifications

GOC:integral component of plasma membrane, F:angiotensin type I receptor activity, F:angiotensin type II receptor activity, P:calcium-mediated signaling, P:cell chemotaxis, P:kidney development, P:low-density lipoprotein particle remodeling, P:positive regulation of cellular protein metabolic process, P:positive regulation of cholesterol esterification, P:positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway, P:positive regulation of inflammatory response, P:positive regulation of macrophage derived foam cell differentiation, P:positive regulation of NAD(P)H oxidase activity, P:positive regulation of phospholipase A2 activity, P:positive regulation of reactive oxygen species metabolic process, P:regulation of blood vessel size by renin-angiotensin, P:regulation of cell growth, P:regulation of cell proliferation, P:regulation of renal sodium excretion, P:regulation of vasoconstriction, P:regulation of vasodilation, P:renin-angiotensin regulation of aldosterone production, P:Rho protein signal transduction, C:integral component of membrane, P:angiotensin-activated signaling pathway, C:integral to plasma membrane, F:acetyltransferase activator activity, P:elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway, C:integral to membrane
UniProt3D-structure, Cell membrane, Complete proteome, Disease mutation, Disulfide bond, G-protein coupled receptor, Glycoprotein, Lipoprotein, Membrane, Palmitate, Phosphoprotein, Polymorphism, Receptor, Reference proteome, Transducer, Transmembrane, Transmembrane helix
PADBRCP: receptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)1.540.0181532920136355
Exp21216829Homo sapiens8BloodCD8+RRMS_(CD8+) (Multiple sclerosis)0.210.0215069221216829
Exp22252466AHomo sapiens13BloodCD34- HPCRRMS_SPMS (Multiple sclerosis)1.194.19E-0222252466

Compile date 09-07-2016© MuScle project