MuScle-logoMuScle - Molecule ID B0464

geneAGRN, AGRIN
nameAgrin
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AGRIN_HUMANO00468ENSG00000188157375790Hs.273330103320, 254300

Functions and classifications

GOC:basal lamina, C:cell junction, C:cell surface, C:extracellular space, C:Golgi lumen, C:integral component of membrane, C:lysosomal lumen, C:plasma membrane, C:synapse, F:acetylcholine receptor regulator activity, F:calcium ion binding, F:chondroitin sulfate binding, F:dystroglycan binding, F:heparan sulfate proteoglycan binding, F:laminin binding, F:sialic acid binding, F:structural constituent of cytoskeleton, P:axon guidance, P:carbohydrate metabolic process, P:chondroitin sulfate metabolic process, P:clustering of voltage-gated sodium channels, P:extracellular matrix organization, P:G-protein coupled acetylcholine receptor signaling pathway, P:glycosaminoglycan biosynthetic process, P:glycosaminoglycan catabolic process, P:neuromuscular junction development, P:neurotransmitter receptor metabolic process, P:phototransduction, visible light, P:plasma membrane organization, P:positive regulation of filopodium assembly, P:positive regulation of neuron apoptotic process, P:positive regulation of Rho GTPase activity, P:positive regulation of synaptic growth at neuromuscular junction, P:positive regulation of transcription from RNA polymerase II promoter, P:receptor clustering, P:regulation of receptor activity, P:retinoid metabolic process, P:synapse organization, C:basal lamina, P:positive regulation of protein geranylgeranylation, P:positive regulation of protein phosphorylation, P:regulation of Rac GTPase activity, P:synapse assembly, P:synapse organization
UniProtAlternative splicing, Calcium, Cell junction, Cell membrane, Complete proteome, Congenital myasthenic syndrome, Developmental protein, Differentiation, Disease mutation, Disulfide bond, EGF-like domain, Extracellular matrix, Glycoprotein, Heparan sulfate, Laminin EGF-like domain, Membrane, Polymorphism, Proteoglycan, Reference proteome, Repeat, Secreted, Signal, Synapse, Transmembrane, Transmembrane helix
PADBCS: Cell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_1_day_follow-up) (Multiple sclerosis)1.436.75E-0317467740
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)1.491.14E-0420136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)2.016.20E-1020136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)1.460.0002771220136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)1.600.0000953720136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_2_days_follow-up) (Multiple sclerosis)1.260.0126770520136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_24_month_follow-up) (Multiple sclerosis)1.290.0217713320136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_24_month_follow-up) (Multiple sclerosis)1.410.0069444220136355
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_12_month_follow-up) (Multiple sclerosis)1.570.0164323721886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_12_month_follow-up) (Multiple sclerosis)1.940.0101517521886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_24_month_follow-up) (Multiple sclerosis)1.460.002066721886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_24_month_follow-up) (Multiple sclerosis)1.680.016441321886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)1.922.19E-0421886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)2.351.17E-0421886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1b_24_month_follow-up) (Multiple sclerosis)1.310.009050321886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1b_24_month_follow-up) (Multiple sclerosis)1.580.012198721886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1b_3_month_follow-up) (Multiple sclerosis)1.450.0016885121886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1b_3_month_follow-up) (Multiple sclerosis)1.580.0099501921886806
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.916.86E-0322021740
Exp22252466AHomo sapiens13BloodCD34- HPCRRMS_SPMS (Multiple sclerosis)0.892.82E-0222252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)0.892.55E-0223895517

Compile date 09-07-2016© MuScle project