MuScle-logoMuScle - Molecule ID B0411

geneADRB2, ADRB2R, B2AR
nameBeta-2 adrenergic receptor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ADRB2_HUMANP07550ENSG00000169252154Hs.2551109690

Functions and classifications

GOC:apical plasma membrane, C:endosome, C:integral component of plasma membrane, C:lysosome, C:nucleus, C:receptor complex, F:beta2-adrenergic receptor activity, F:norepinephrine binding, F:potassium channel regulator activity, F:protein homodimerization activity, P:activation of adenylate cyclase activity, P:activation of transmembrane receptor protein tyrosine kinase activity, P:adenylate cyclase-activating G-protein coupled receptor signaling pathway, P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway, P:bone resorption, P:brown fat cell differentiation, P:desensitization of G-protein coupled receptor protein signaling pathway by arrestin, P:diet induced thermogenesis, P:endosome to lysosome transport, P:heat generation, P:negative regulation of multicellular organism growth, P:negative regulation of smooth muscle contraction, P:positive regulation of bone mineralization, P:positive regulation of MAPK cascade, P:positive regulation of protein ubiquitination, P:positive regulation of transcription from RNA polymerase II promoter, P:receptor-mediated endocytosis, P:regulation of sodium ion transport, P:regulation of vasodilation, P:response to cold, P:vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure, C:integral component of membrane, P:adrenergic receptor signaling pathway, "C:apical plasma membrane, C:axon, C:caveola, C:dendritic spine, C:integral to plasma membrane, C:neuronal cell body membrane, C:sarcolemma, F:dopamine binding, F:drug binding, F:epinephrine binding, P:diaphragm contraction, P:negative regulation of inflammatory response, P:negative regulation of ossification, P:negative regulation of urine volume, P:positive regulation of apoptotic process, P:positive regulation of cell proliferation, P:positive regulation of potassium ion transport, P:positive regulation of skeletal muscle tissue growth, P:positive regulation of sodium ion transport, P:positive regulation of the force of heart contraction by epinephrine, P:positive regulation of vasodilation, P:regulation of excitatory postsynaptic membrane potential, P:regulation of sensory perception of pain, P:synaptic transmission, glutamatergic, P:wound healing", C:integral to membrane
UniProt3D-structure, Cell membrane, Complete proteome, Disulfide bond, G-protein coupled receptor, Glycoprotein, Hydroxylation, Lipoprotein, Membrane, Palmitate, Phosphoprotein, Polymorphism, Receptor, Reference proteome, Transducer, Transmembrane, Transmembrane helix, Ubl conjugation
PADBRCP: receptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_1_day_follow-up) (Multiple sclerosis)1.372.10E-0217467740
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)0.790.0016175520136355
Exp20921521Homo sapiens10Blood PPMS_(PRF1_gene_Risk_haplotype) (Multiple sclerosis)0.460.007604620921521
Exp21346816Homo sapiens12Blood MS (Multiple sclerosis)1.280.03239421346816
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.802.64E-0322021740
Exp22252466AHomo sapiens13BloodCD34+ HPCRRMS_SPMS (Multiple sclerosis)1.470.047516322252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.067.17E-1322252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.689.60E-0323895517
Exp24850724Homo sapiens12Blood CIS (Multiple sclerosis)1.780.0262213224850724

Compile date 09-07-2016© MuScle project