MuScle-logoMuScle - Molecule ID B0410

geneADRB1, ADRB1R, B1AR
nameBeta-1 adrenergic receptor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ADRB1_HUMANP08588ENSG00000043591153Hs.99913109630, 607276

Functions and classifications

GOC:early endosome, C:integral component of plasma membrane, C:nucleus, F:beta1-adrenergic receptor activity, F:dopamine binding, F:drug binding, F:epinephrine binding, F:norepinephrine binding, F:Ras guanyl-nucleotide exchange factor activity, F:receptor signaling protein activity, P:activation of adenylate cyclase activity, P:adenylate cyclase-activating adrenergic receptor signaling pathway, P:aging, P:apoptotic process, P:brown fat cell differentiation, P:diet induced thermogenesis, P:fear response, P:glycogen catabolic process, P:heat generation, P:lipid homeostasis, P:memory, P:negative regulation of multicellular organism growth, P:negative regulation of smooth muscle contraction, P:negative regulation of urine volume, P:positive regulation of apoptotic process, P:positive regulation of cAMP-mediated signaling, P:positive regulation of cation channel activity, P:positive regulation of cell growth involved in cardiac muscle cell development, P:positive regulation of heart rate by epinephrine-norepinephrine, P:positive regulation of Ras GTPase activity, P:positive regulation of renin secretion into blood stream, P:positive regulation of saliva secretion, P:positive regulation of systemic arterial blood pressure, P:positive regulation of the force of heart contraction by norepinephrine, P:protein localization to organelle, P:regulation of calcium ion transport, P:regulation of cardiac muscle cell contraction, P:regulation of inhibitory postsynaptic membrane potential, P:response to cold, P:Rho protein signal transduction, P:sensory perception of pain, P:vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure, P:wound healing, C:cytoplasm, C:integral to plasma membrane, P:adenylate cyclase-activating G-protein coupled receptor signaling pathway
UniProt3D-structure, Cell membrane, Complete proteome, Disulfide bond, Endosome, G-protein coupled receptor, Glycoprotein, Lipoprotein, Membrane, Palmitate, Phosphoprotein, Polymorphism, Receptor, Reference proteome, Transducer, Transmembrane, Transmembrane helix
PADBRCP: receptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50BloodRRMS_(rIFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)1.444.63E-0220136355
Exp21886806Homo sapiens12BloodRRMS_(IFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)0.840.0466721886806
Exp22491253Homo sapiens7BloodRRMS_(High_Sema4A) (Multiple sclerosis)0.260.0470376222491253

Compile date 09-07-2016© MuScle project