MuScle-logoMuScle - Molecule ID B0383

geneADD1, ADDA
nameAlpha adducin
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ADDA_HUMANP35611ENSG00000087274118Hs.183706102680

Functions and classifications

GOC:cytosol, C:dendritic spine, C:F-actin capping protein complex, C:nucleus, C:perinuclear region of cytoplasm, C:plasma membrane, C:postsynaptic density, F:actin filament binding, F:spectrin binding, F:structural molecule activity, P:actin filament bundle assembly, P:activation of signaling protein activity involved in unfolded protein response, P:barbed-end actin filament capping, P:cell morphogenesis, P:cell volume homeostasis, P:cellular component disassembly involved in execution phase of apoptosis, P:cellular protein metabolic process, P:cellular response to retinoic acid, P:erythrocyte differentiation, P:hemoglobin metabolic process, P:homeostasis of number of cells within a tissue, P:in utero embryonic development, P:multicellular organism growth, P:positive regulation of angiogenesis, P:positive regulation of endocytosis, P:positive regulation of protein binding, C:membrane, P:negative regulation of actin filament polymerization, C:cytoskeleton, F:calmodulin binding, P:cytoskeleton organization, C:synapse, F:metal ion binding
UniProtAcetylation, Actin-binding, Alternative splicing, Calmodulin-binding, Cell membrane, Complete proteome, Cytoplasm, Cytoskeleton, Direct protein sequencing, Membrane, Phosphoprotein, Polymorphism, Reference proteome
PADBCS: Cell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_1_day_follow-up) (Multiple sclerosis)1.561.65E-0217467740
Exp20921521Homo sapiens10Blood PPMS_(PRF1_gene_Risk_haplotype) (Multiple sclerosis)0.870.001018820921521
Exp21216829Homo sapiens8BloodCD4+RRMS_(CD4+) (Multiple sclerosis)0.100.042735121216829
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)0.771.17E-0221886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)0.802.73E-0221886806
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.764.78E-0422021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.863.25E-0422021740
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.733.85E-0522252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)1.444.32E-0422252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.102.03E-0223895517

Compile date 09-07-2016© MuScle project