MuScle-logoMuScle - Molecule ID B0356

geneADAM8, MS2
nameADAM 8 precursor
speciesHomo sapiens

Molecule reference


Functions and classifications

GOC:alpha9-beta1 integrin-ADAM8 complex, C:cell surface, C:dense core granule membrane, C:integral component of plasma membrane, C:phagolysosome, C:podosome, C:specific granule, C:tertiary granule, F:calcium ion binding, F:metalloendopeptidase activity, F:metallopeptidase activity, F:protein self-association, F:zinc ion binding, P:activation of MAPK activity involved in innate immune response, P:angiogenesis, P:cell morphogenesis, P:cell-cell adhesion, P:cellular response to hypoxia, P:leukocyte migration involved in inflammatory response, P:lymphocyte chemotaxis, P:negative regulation of neuron apoptotic process, P:positive regulation of acute inflammatory response, P:positive regulation of bone resorption, P:positive regulation of cell adhesion, P:positive regulation of eosinophil migration, P:positive regulation of fibronectin-dependent thymocyte migration, P:positive regulation of membrane protein ectodomain proteolysis, P:positive regulation of neutrophil extravasation, P:positive regulation of NF-kappaB transcription factor activity, P:positive regulation of protein kinase B signaling, P:positive regulation of protein processing, P:positive regulation of protein secretion, P:positive regulation of T cell differentiation in thymus, P:positive regulation of thymocyte apoptotic process, P:positive regulation of tumor necrosis factor (ligand) superfamily member 11 production, P:proteolysis, P:regulation of cell-cell adhesion, C:extracellular region, P:integrin-mediated signaling pathway, C:integral to plasma membrane, P:positive regulation of protein kinase B signaling cascade, F:metal ion binding
UniProt3D-structure, Alternative splicing, Complete proteome, Disulfide bond, EGF-like domain, Glycoprotein, Hydrolase, Membrane, Metal-binding, Metalloprotease, Polymorphism, Protease, Reference proteome, Signal, Transmembrane, Transmembrane helix, Zinc, Integrin, Secreted
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_1_day_follow-up) (Multiple sclerosis)1.374.31E-0217467740
Exp21216829Homo sapiens8BloodCD8+RRMS_(CD8+) (Multiple sclerosis)0.240.0361846521216829
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.413.98E-0222021740
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.732.42E-0222252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.331.13E-0223895517

Compile date 09-07-2016© MuScle project