MuScle-logoMuScle - Molecule ID B0346

geneADRA2C, ADRA2L2, ADRA2RL2
nameAlpha-2C-adrenergic receptor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ADA2C_HUMANP18825ENSG00000184160152Hs.123022104250

Functions and classifications

GOC:axon terminus, C:endosome, C:integral component of plasma membrane, F:alpha2-adrenergic receptor activity, F:epinephrine binding, F:protein homodimerization activity, P:activation of MAPK activity by adrenergic receptor signaling pathway, P:activation of protein kinase B activity, P:cell-cell signaling, P:energy reserve metabolic process, P:epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway, P:female pregnancy, P:negative regulation of epinephrine secretion, P:negative regulation of norepinephrine secretion, P:negative regulation of uterine smooth muscle contraction, P:platelet activation, P:positive regulation of neuron differentiation, P:positive regulation of vasoconstriction, P:regulation of insulin secretion, P:regulation of sensory perception of pain, P:small molecule metabolic process, C:integral component of membrane, C:plasma membrane, P:adrenergic receptor signaling pathway, P:regulation of smooth muscle contraction, P:regulation of vasoconstriction, C:axon, C:integral to plasma membrane, C:integral to membrane
UniProtCell membrane, Complete proteome, Disulfide bond, G-protein coupled receptor, Glycoprotein, Membrane, Polymorphism, Receptor, Reference proteome, Transducer, Transmembrane, Transmembrane helix
PADBRCP: receptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_1_day_follow-up) (Multiple sclerosis)1.528.03E-0317467740
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)0.607.82E-0320136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_24_month_follow-up) (Multiple sclerosis)0.680.038567820136355
Exp21216829Homo sapiens8BloodCD8+RRMS_(CD8+) (Multiple sclerosis)0.470.0317092321216829
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.884.22E-0222252466

Compile date 09-07-2016© MuScle project