MuScle-logoMuScle - Molecule ID B0335

nameAlpha-1A adrenergic receptor
speciesHomo sapiens

Molecule reference


Functions and classifications

GOC:integral component of plasma membrane, C:nuclear membrane, C:T-tubule, C:Z disc, F:alpha1-adrenergic receptor activity, F:protein heterodimerization activity, P:activation of phospholipase C activity, P:adult heart development, P:aging, P:apoptotic process, P:calcium ion transport into cytosol, P:cell growth, P:cell-cell signaling, P:intracellular signal transduction, P:micturition, P:negative regulation of cell proliferation, P:negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure, P:negative regulation of Rho protein signal transduction, P:negative regulation of synaptic transmission, GABAergic, P:norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure, P:organ growth, P:phospholipase C-activating G-protein coupled receptor signaling pathway, P:pilomotor reflex, P:positive regulation of action potential, P:positive regulation of cardiac muscle contraction, P:positive regulation of ERK1 and ERK2 cascade, P:positive regulation of heart rate by epinephrine-norepinephrine, P:positive regulation of protein kinase C signaling, P:positive regulation of smooth muscle contraction, P:positive regulation of systemic arterial blood pressure, P:positive regulation of the force of heart contraction by epinephrine-norepinephrine, P:positive regulation of vasoconstriction, P:response to drug, P:response to hormone, P:smooth muscle contraction, C:integral component of membrane, P:adrenergic receptor signaling pathway, P:regulation of cardiac muscle contraction, P:regulation of vasoconstriction, C:plasma membrane, "C:integral component of membrane, P:response to hormone", "C:integral to plasma membrane, P:intracellular protein kinase cascade, P:positive regulation of protein kinase C signaling cascade, P:response to hormone stimulus, P:response to stress, C:integral to membrane, "C:integral to membrane, P:elevation of cytosolic calcium ion concentration, P:positive regulation of MAPK cascade, P:response to stress"
UniProtAlternative splicing, Cell membrane, Complete proteome, Disulfide bond, G-protein coupled receptor, Glycoprotein, Lipoprotein, Membrane, Nucleus, Palmitate, Phosphoprotein, Polymorphism, Receptor, Reference proteome, Transducer, Transmembrane, Transmembrane helix
PADBRCP: receptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50BloodRRMS_(rIFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)0.630.0128914720136355
Exp20136355Homo sapiens50BloodRRMS_(rIFN-Beta-1b_2_days_follow-up) (Multiple sclerosis)1.570.0391680720136355
Exp21886806Homo sapiens12BloodRRMS_(IFN-Beta-1a_24_month_follow-up) (Multiple sclerosis)0.810.022867621886806

Compile date 09-07-2016© MuScle project