MuScle-logoMuScle - Molecule ID B0332

nameADAM 17 precursor
speciesHomo sapiens

Molecule reference

ADA17_HUMANP78536ENSG000001516946868Hs.404914603639, 614328

Functions and classifications

GOC:actin cytoskeleton, C:apical plasma membrane, C:cell surface, C:cytoplasm, C:integral component of plasma membrane, C:membrane raft, F:metalloendopeptidase activity, F:Notch binding, F:zinc ion binding, P:apoptotic signaling pathway, P:B cell differentiation, P:cell adhesion mediated by integrin, P:collagen catabolic process, P:epidermal growth factor receptor signaling pathway, P:epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway, P:extracellular matrix disassembly, P:germinal center formation, P:JAK-STAT cascade involved in growth hormone signaling pathway, P:membrane protein intracellular domain proteolysis, P:negative regulation of interleukin-8 production, P:neurotrophin TRK receptor signaling pathway, P:neutrophil mediated immunity, P:Notch receptor processing, P:Notch signaling pathway, P:PMA-inducible membrane protein ectodomain proteolysis, P:positive regulation of cell growth, P:positive regulation of cell proliferation, P:positive regulation of chemokine production, P:positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle, P:positive regulation of T cell chemotaxis, P:positive regulation of transforming growth factor beta receptor signaling pathway, P:regulation of mast cell apoptotic process, P:response to drug, P:response to high density lipoprotein particle, P:response to hypoxia, P:response to lipopolysaccharide, P:spleen development, P:T cell differentiation in thymus, P:wound healing, spreading of epidermal cells, P:cell motility, P:positive regulation of cellular component movement, P:proteolysis, F:metallopeptidase activity, C:integral to plasma membrane, F:metal ion binding, P:nerve growth factor receptor signaling pathway, P:positive regulation of cyclin-dependent protein kinase activity involved in G1/S, P:response to high density lipoprotein particle stimulus, C:plasma membrane
UniProt3D-structure, Alternative splicing, Cleavage on pair of basic residues, Complete proteome, Direct protein sequencing, Disulfide bond, Glycoprotein, Hydrolase, Membrane, Metal-binding, Metalloprotease, Notch signaling pathway, Phosphoprotein, Polymorphism, Protease, Reference proteome, SH3-binding, Signal, Transmembrane, Transmembrane helix, Zinc, Zymogen
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_1_day_follow-up) (Multiple sclerosis)1.484.26E-0217467740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.133.27E-0222021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.153.36E-0222021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)2.451.49E-0722021740
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.608.35E-0322252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.833.63E-0222252466

Compile date 09-07-2016© MuScle project