MuScle-logoMuScle - Molecule ID B0330

geneADAM12, MLTN, UNQ346/PRO545
nameADAM 12 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ADA12_HUMANO43184ENSG000001488488038Hs.594351602714

Functions and classifications

GOC:extracellular region, C:integral component of membrane, C:mitochondrion, C:nucleus, C:plasma membrane, F:metalloendopeptidase activity, F:metallopeptidase activity, F:zinc ion binding, P:cell adhesion, P:epidermal growth factor receptor signaling pathway, P:myoblast fusion, P:proteolysis, C:integral to membrane, F:metal ion binding
UniProtAlternative splicing, Cell adhesion, Cell membrane, Cleavage on pair of basic residues, Complete proteome, Disulfide bond, EGF-like domain, Glycoprotein, Hydrolase, Membrane, Metal-binding, Metalloprotease, Phosphoprotein, Polymorphism, Protease, Reference proteome, Secreted, SH3-binding, Signal, Transmembrane, Transmembrane helix, Zinc, Zymogen
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp21216829Homo sapiens8BloodCD4+RRMS_(CD4+) (Multiple sclerosis)9.710.029397321216829
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_12_month_follow-up) (Multiple sclerosis)1.200.0282143821886806
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.943.27E-0222021740
Exp22252466AHomo sapiens13BloodCD34+ HPCRRMS_SPMS (Multiple sclerosis)1.140.025244522252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.597.79E-0522252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.909.73E-0322252466
Exp22491253Homo sapiens7Blood RRMS_(High_Sema4A) (Multiple sclerosis)0.570.0248665622491253
Exp22491253Homo sapiens7Blood RRMS_(Low_Sema4A) (Multiple sclerosis)0.550.021093222491253
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)0.952.90E-0223895517

Compile date 09-07-2016© MuScle project