MuScle-logoMuScle - Molecule ID B0328

geneADAM10, KUZ, MADM
nameADAM 10 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ADA10_HUMANO14672ENSG00000137845102Hs.578508602192

Functions and classifications

GOC:cell surface, C:endomembrane system, C:Golgi-associated vesicle, C:integral component of membrane, C:nucleus, C:plasma membrane, C:postsynaptic density, F:integrin binding, F:metalloendopeptidase activity, F:protein homodimerization activity, F:protein kinase binding, F:zinc ion binding, P:cell-cell signaling, P:collagen catabolic process, P:constitutive protein ectodomain proteolysis, P:epidermal growth factor receptor signaling pathway, P:extracellular matrix disassembly, P:in utero embryonic development, P:integrin-mediated signaling pathway, P:monocyte activation, P:negative regulation of cell adhesion, P:Notch receptor processing, P:Notch signaling pathway, P:PMA-inducible membrane protein ectodomain proteolysis, P:positive regulation of cell growth, P:positive regulation of cell proliferation, P:positive regulation of T cell chemotaxis, P:protein phosphorylation, P:response to tumor necrosis factor, F:metallopeptidase activity, P:metabolic process, P:proteolysis, C:extracellular region, P:membrane protein ectodomain proteolysis, C:integral to membrane, F:metal ion binding
UniProt3D-structure, Cell membrane, Cleavage on pair of basic residues, Complete proteome, Direct protein sequencing, Disulfide bond, Glycoprotein, Hydrolase, Membrane, Metal-binding, Metalloprotease, Notch signaling pathway, Polymorphism, Protease, Reference proteome, SH3-binding, Signal, Transmembrane, Transmembrane helix, Zinc, Zymogen, Integrin
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_6_month_follow-up) (Multiple sclerosis)1.394.41E-0217467740
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)1.143.89E-0220136355
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)1.642.00E-0321886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)1.652.80E-0221886806
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.094.99E-0222021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.276.76E-0422021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.421.23E-0522021740
Exp22252466AHomo sapiens13BloodCD34+ HPCRRMS_SPMS (Multiple sclerosis)1.330.002336522252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.243.28E-1422252466

Compile date 09-07-2016© MuScle project