MuScle-logoMuScle - Molecule ID B0311

geneACTN4
nameAlpha-actinin 4
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACTN4_HUMANO43707ENSG0000013040281Hs.270291603278, 604638

Functions and classifications

GOC:cell-cell junction, C:cortical cytoskeleton, C:extracellular vesicular exosome, C:neuron projection, C:nucleus, C:perinuclear region of cytoplasm, C:platelet alpha granule lumen, C:protein complex, C:pseudopodium, C:ribonucleoprotein complex, C:stress fiber, C:Z disc, F:actin filament binding, F:calcium ion binding, F:integrin binding, F:nucleoside binding, F:protein homodimerization activity, P:actin filament bundle assembly, P:negative regulation of cellular component movement, P:platelet activation, P:platelet degranulation, P:positive regulation of cellular component movement, P:positive regulation of pinocytosis, P:positive regulation of sodium:hydrogen antiporter activity, P:protein transport, P:regulation of apoptotic process, P:response to hypoxia, P:tight junction assembly, P:protein localization, P:actin crosslink formation
UniProt3D-structure, Acetylation, Actin-binding, Alternative splicing, Calcium, Cell junction, Complete proteome, Cytoplasm, Disease mutation, Isopeptide bond, Metal-binding, Nucleus, Protein transport, Reference proteome, Repeat, Transport, Ubl conjugation
PADBCS: Cell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp22252466AHomo sapiens13BloodCD34- HPCRRMS_SPMS (Multiple sclerosis)0.676.66E-0322252466
Exp22252466AHomo sapiens13BloodCD34- HPCRRMS_SPMS (Multiple sclerosis)0.762.46E-0222252466
Exp22252466AHomo sapiens13BloodCD34+ HPCRRMS_SPMS (Multiple sclerosis)1.390.007348622252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.254.48E-0223895517

Compile date 09-07-2016© MuScle project