MuScle-logoMuScle - Molecule ID B0308

geneACTN1
nameAlpha-actinin 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACTN1_HUMANP12814ENSG0000007211087Hs.509765102575, 615193

Functions and classifications

GOC:cytoskeleton, C:cytosol, C:dendritic spine, C:extracellular vesicular exosome, C:fascia adherens, C:focal adhesion, C:nucleus, C:plasma membrane, C:platelet alpha granule lumen, C:pseudopodium, C:ruffle, C:Z disc, F:calcium ion binding, F:double-stranded RNA binding, F:integrin binding, P:actin filament bundle assembly, P:extracellular matrix organization, P:focal adhesion assembly, P:negative regulation of cellular component movement, P:platelet activation, P:platelet degranulation, P:regulation of apoptotic process, C:cortical actin cytoskeleton, C:stress fiber, P:actin crosslink formation
UniProt3D-structure, Acetylation, Actin-binding, Alternative splicing, Calcium, Cell junction, Cell membrane, Cell projection, Complete proteome, Cytoplasm, Cytoskeleton, Direct protein sequencing, Disease mutation, Membrane, Metal-binding, Phosphoprotein, Polymorphism, Reference proteome, Repeat
PADBCS: Cell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)0.784.20E-0420136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)0.803.99E-0220136355
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)0.681.57E-0421886806
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.243.67E-0222021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.421.55E-0222021740
Exp22252466AHomo sapiens13BloodCD34- HPCRRMS_SPMS (Multiple sclerosis)0.674.05E-0222252466

Compile date 09-07-2016© MuScle project