MuScle-logoMuScle - Molecule ID B0290

geneACSL4, ACS4, FACL4
nameLong-chain-fatty-acid--CoA ligase 4
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACSL4_HUMANO60488ENSG000000683662182Hs.268785300157, 300194, 300387

Functions and classifications

GOC:endoplasmic reticulum membrane, C:integral component of membrane, C:lipid particle, C:mitochondrial outer membrane, C:neuronal cell body, C:peroxisomal membrane, F:arachidonate-CoA ligase activity, F:ATP binding, F:long-chain fatty acid-CoA ligase activity, F:very long-chain fatty acid-CoA ligase activity, P:dendritic spine development, P:embryonic process involved in female pregnancy, P:fatty acid transport, P:lipid biosynthetic process, P:long-chain fatty-acyl-CoA biosynthetic process, P:negative regulation of prostaglandin secretion, P:positive regulation of cell growth, P:response to interleukin-15, P:response to nutrient, P:triglyceride biosynthetic process, F:catalytic activity, C:mitochondrial membrane, C:peroxisome, P:long-chain fatty acid metabolic process, P:triglyceride metabolic process, F:ligase activity, C:integral to membrane, C:endoplasmic reticulum
UniProtAlport syndrome, Alternative splicing, ATP-binding, Complete proteome, Deafness, Disease mutation, Elliptocytosis, Endoplasmic reticulum, Fatty acid metabolism, Hereditary hemolytic anemia, Ligase, Lipid metabolism, Magnesium, Membrane, Mental retardation, Microsome, Mitochondrion, Mitochondrion outer membrane, Nucleotide-binding, Peroxisome, Polymorphism, Reference proteome, Signal-anchor, Transmembrane, Transmembrane helix
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_1_day_follow-up) (Multiple sclerosis)1.871.70E-0317467740
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_6_month_follow-up) (Multiple sclerosis)1.521.50E-0217467740
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)1.530.03730421886806
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.383.41E-0322021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.473.11E-0222021740
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.685.88E-0322252466
Exp22491253Homo sapiens7Blood RRMS_(Low_Sema4A) (Multiple sclerosis)2.350.023647822491253

Compile date 09-07-2016© MuScle project