MuScle-logoMuScle - Molecule ID B0289

geneACSL1, FACL1, FACL2
nameLong-chain-fatty-acid--CoA ligase 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACSL1_HUMANP33121ENSG000001517262180Hs.406678152425, 152426

Functions and classifications

GOC:endoplasmic reticulum membrane, C:integral component of membrane, C:mitochondrial outer membrane, C:peroxisomal membrane, C:plasma membrane, F:ATP binding, F:long-chain fatty acid-CoA ligase activity, P:adiponectin-activated signaling pathway, P:alpha-linolenic acid metabolic process, P:linoleic acid metabolic process, P:long-chain fatty acid import, P:long-chain fatty-acyl-CoA biosynthetic process, P:positive regulation of protein serine/threonine kinase activity, P:response to drug, P:response to nutrient, P:response to oleic acid, P:response to organic cyclic compound, P:triglyceride biosynthetic process, P:xenobiotic catabolic process, F:ligase activity, F:catalytic activity, C:endoplasmic reticulum, P:fatty acid transport, P:long-chain fatty acid metabolic process, P:triglyceride metabolic process, C:integral to membrane, P:adiponectin-mediated signaling pathway, P:regulation of fatty acid oxidation
UniProtAcetylation, Alternative splicing, ATP-binding, Complete proteome, Direct protein sequencing, Endoplasmic reticulum, Fatty acid metabolism, Ligase, Lipid metabolism, Magnesium, Membrane, Microsome, Mitochondrion, Mitochondrion outer membrane, Nitration, Nucleotide-binding, Peroxisome, Phosphoprotein, Reference proteome, Signal-anchor, Transmembrane, Transmembrane helix
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_1_day_follow-up) (Multiple sclerosis)1.461.88E-0217467740
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_1_day_follow-up) (Multiple sclerosis)1.785.66E-0417467740
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_6_month_follow-up) (Multiple sclerosis)1.732.25E-0317467740
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)1.330.0253645720136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_24_month_follow-up) (Multiple sclerosis)1.250.044603320136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_24_month_follow-up) (Multiple sclerosis)1.290.027029820136355
Exp20921521Homo sapiens10Blood PPMS_(PRF1_gene_Risk_haplotype) (Multiple sclerosis)0.560.042016320921521
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.152.59E-0922252466

Compile date 09-07-2016© MuScle project