MuScle-logoMuScle - Molecule ID B0266

geneACO1, IRP1, IREB1
nameIron-responsive element binding protein 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACOC_HUMANP21399ENSG0000012272948Hs.567229100880

Functions and classifications

GOC:cytosol, C:endoplasmic reticulum, C:Golgi apparatus, C:mitochondrion, F:4 iron, 4 sulfur cluster binding, F:aconitate hydratase activity, F:iron-responsive element binding, F:metal ion binding, P:cellular iron ion homeostasis, P:citrate metabolic process, P:intestinal absorption, P:post-embryonic development, P:regulation of translation, P:response to iron(II) ion, P:tricarboxylic acid cycle, P:metabolic process, P:regulation of translation", "F:4 iron, 4 sulfur cluster binding, P:metabolic process", F:citrate hydro-lyase (cis-aconitate-forming) activity, F:isocitrate hydro-lyase (cis-aconitate-forming) activity, F:mRNA 5'-UTR binding
UniProt3D-structure, 4Fe-4S, Complete proteome, Cytoplasm, Direct protein sequencing, Iron, Iron-sulfur, Lyase, Metal-binding, Polymorphism, Reference proteome, RNA-binding, Tricarboxylic acid cycle
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_1_day_follow-up) (Multiple sclerosis)0.657.41E-0317467740
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_1_day_follow-up) (Multiple sclerosis)1.512.65E-0217467740
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)0.721.69E-0221886806
Exp22252466AHomo sapiens13BloodCD34- HPCRRMS_SPMS (Multiple sclerosis)0.824.94E-0222252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)2.082.13E-0622252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)2.196.62E-0822252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.128.61E-0323895517

Compile date 09-07-2016© MuScle project