MuScle-logoMuScle - Molecule ID B0254

geneACLY
nameATP-citrate synthase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACLY_HUMANP53396ENSG00000131473|ENSG0000026024547Hs.387567108728

Functions and classifications

GOC:citrate lyase complex, C:cytosol, C:mitochondrion, C:nucleus, C:plasma membrane, F:ATP binding, F:ATP citrate synthase activity, F:cofactor binding, F:metal ion binding, F:succinate-CoA ligase (ADP-forming) activity, P:ATP catabolic process, P:cellular carbohydrate metabolic process, P:citrate metabolic process, P:coenzyme A metabolic process, P:energy reserve metabolic process, P:long-chain fatty-acyl-CoA biosynthetic process, P:positive regulation of cellular metabolic process, P:triglyceride biosynthetic process, C:cytoplasm, F:nucleotide binding
UniProt3D-structure, Acetylation, Alternative splicing, ATP-binding, Complete proteome, Cytoplasm, Isopeptide bond, Lipid biosynthesis, Lipid metabolism, Magnesium, Metal-binding, Nucleotide-binding, Phosphoprotein, Polymorphism, Reference proteome, Transferase, Ubl conjugation
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)1.104.13E-0220136355
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.344.27E-0822021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.491.63E-0522021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.857.77E-0922021740
Exp22252466AHomo sapiens13BloodCD34+ HPCRRMS_SPMS (Multiple sclerosis)1.300.045408522252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.114.32E-0223895517

Compile date 09-07-2016© MuScle project