MuScle-logoMuScle - Molecule ID B0225

geneACER3, APHC, PHCA
nameAlkaline ceramidase 3
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGene
ACER3_HUMANQ9NUN7ENSG00000078124|ENSG0000026297055331Hs.23862

Functions and classifications

GOC:integral component of endoplasmic reticulum membrane, C:integral component of Golgi membrane, F:phytoceramidase activity, P:ceramide metabolic process, P:phytosphingosine biosynthetic process, P:positive regulation of cell proliferation, P:sphingosine biosynthetic process, "C:integral component of membrane, F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides, P:ceramide metabolic process", C:integral to endoplasmic reticulum membrane, C:integral to Golgi membrane, P:phospholipid metabolic process, "C:integral to membrane
UniProtAlternative splicing, Complete proteome, Endoplasmic reticulum, Glycoprotein, Golgi apparatus, Hydrolase, Membrane, Reference proteome, Transmembrane, Transmembrane helix
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_2_days_follow-up) (Multiple sclerosis)0.852.24E-0220136355
Exp21216829Homo sapiens8BloodCD8+RRMS_(CD8+) (Multiple sclerosis)0.510.0426386721216829
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_24_month_follow-up) (Multiple sclerosis)1.410.021288221886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)1.561.03E-0221886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)1.821.64E-0221886806
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.912.46E-0222021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.221.52E-0222021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.711.77E-0822021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.904.33E-0722021740
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.216.93E-1422252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.283.77E-1022252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.515.94E-0722252466

Compile date 09-07-2016© MuScle project