MuScle-logoMuScle - Molecule ID B0198

geneACACA, ACAC, ACC1
nameAcetyl-CoA carboxylase 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACACA_HUMANQ13085ENSG0000013214231Hs.160556200350, 613933

Functions and classifications

GOC:cytosol, C:mitochondrion, F:acetyl-CoA carboxylase activity, F:ATP binding, F:biotin carboxylase activity, F:metal ion binding, P:acetyl-CoA metabolic process, P:biotin metabolic process, P:carnitine shuttle, P:energy reserve metabolic process, P:fatty acid biosynthetic process, P:lipid homeostasis, P:long-chain fatty-acyl-CoA biosynthetic process, P:malonyl-CoA biosynthetic process, P:multicellular organismal protein metabolic process, P:positive regulation of cellular metabolic process, P:protein homotetramerization, P:tissue homeostasis, P:triglyceride biosynthetic process, F:ligase activity, P:metabolic process, F:biotin binding, P:response to drug, P:response to organic cyclic compound
UniProt3D-structure, Acetylation, Allosteric enzyme, Alternative promoter usage, ATP-binding, Biotin, Complete proteome, Cytoplasm, Direct protein sequencing, Fatty acid biosynthesis, Fatty acid metabolism, Ligase, Lipid biosynthesis, Lipid metabolism, Manganese, Metal-binding, Multifunctional enzyme, Nucleotide-binding, Phosphoprotein, Polymorphism, Reference proteome
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)1.511.57E-0220136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_2_days_follow-up) (Multiple sclerosis)1.594.48E-0220136355
Exp21216829Homo sapiens8BloodCD8+RRMS_(CD8+) (Multiple sclerosis)0.150.0333629621216829
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.811.35E-0222252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)1.111.18E-0222252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)1.241.71E-0222252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.162.94E-0223895517

Compile date 09-07-2016© MuScle project