MuScle-logoMuScle - Molecule ID B0192

geneABR
nameActive breakpoint cluster region-related protein
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ABR_HUMANQ12979ENSG0000015984229Hs.159306600365

Functions and classifications

GOC:cytosol, C:plasma membrane, F:GTPase activator activity, F:Rac GTPase activator activity, F:Rho guanyl-nucleotide exchange factor activity, P:actin cytoskeleton organization, P:apoptotic signaling pathway, P:brain development, P:inner ear morphogenesis, P:negative regulation of cell migration, P:negative regulation of inflammatory response, P:negative regulation of neutrophil degranulation, P:neuromuscular process controlling balance, P:neurotrophin TRK receptor signaling pathway, P:positive regulation of apoptotic process, P:positive regulation of phagocytosis, P:regulation of small GTPase mediated signal transduction, P:response to lipopolysaccharide, P:small GTPase mediated signal transduction, C:intracellular, P:intracellular signal transduction, P:positive regulation of GTPase activity, P:regulation of Rho GTPase activity, P:signal transduction, F:phospholipid binding, P:apoptotic process, P:nerve growth factor receptor signaling pathway, P:regulation of Rho protein signal transduction
UniProtAlternative splicing, Complete proteome, GTPase activation, Guanine-nucleotide releasing factor, Polymorphism, Reference proteome
PADBMOD: modulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20921521Homo sapiens10Blood PPMS_(PRF1_gene_Risk_haplotype) (Multiple sclerosis)0.880.034790720921521
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)1.233.21E-0221886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)1.541.93E-0221886806
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.245.85E-0422021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.531.87E-0522021740
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.372.18E-0822252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.181.45E-0323895517

Compile date 09-07-2016© MuScle project