MuScle-logoMuScle - Molecule ID B0160

geneABCG1, ABC8, WHT1
nameATP-binding cassette, sub-family G, member 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ABCG1_HUMANP45844ENSG000001601799619Hs.124649603076

Functions and classifications

GOC:endoplasmic reticulum membrane, C:external side of plasma membrane, C:Golgi apparatus, C:Golgi membrane, C:integral component of plasma membrane, C:mitochondrion, C:recycling endosome, F:ADP binding, F:ATP binding, F:cholesterol binding, F:cholesterol transporter activity, F:glycoprotein transporter activity, F:phospholipid binding, F:phospholipid transporter activity, F:protein homodimerization activity, F:sterol-transporting ATPase activity, F:toxin transporter activity, P:amyloid precursor protein catabolic process, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol metabolic process, P:detection of hormone stimulus, P:glycoprotein transport, P:high-density lipoprotein particle remodeling, P:intracellular cholesterol transport, P:lipoprotein metabolic process, P:low-density lipoprotein particle remodeling, P:negative regulation of cholesterol storage, P:negative regulation of macrophage derived foam cell differentiation, P:phospholipid efflux, P:phospholipid homeostasis, P:positive regulation of cholesterol biosynthetic process, P:positive regulation of cholesterol efflux, P:regulation of cholesterol esterification, P:regulation of transcription, DNA-templated, P:response to high density lipoprotein particle, P:response to lipid, P:reverse cholesterol transport, F:ATPase activity, P:ATP catabolic process, C:membrane, P:transport, "C:external side of plasma membrane, P:negative regulation of lipid storage, C:integral to plasma membrane, P:regulation of transcription, DNA-dependent, P:response to high density lipoprotein particle stimulus, C:integral to membrane, "C:integral to membrane
UniProtAlternative splicing, ATP-binding, Complete proteome, Endoplasmic reticulum, Golgi apparatus, Lipid transport, Lipoprotein, Membrane, Mitochondrion, Nucleotide-binding, Palmitate, Polymorphism, Reference proteome, Transmembrane, Transmembrane helix, Transport
PADBTP: transport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_2_days_follow-up) (Multiple sclerosis)1.239.68E-0320136355
Exp20921521Homo sapiens10Blood PPMS_(PRF1_gene_Risk_haplotype) (Multiple sclerosis)2.430.012974320921521
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)0.382.05E-0321886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)0.602.90E-0221886806
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.731.77E-0222021740
Exp22252466AHomo sapiens13BloodCD34- HPCRRMS_SPMS (Multiple sclerosis)1.202.37E-0222252466
Exp22252466AHomo sapiens13BloodCD34- HPCRRMS_SPMS (Multiple sclerosis)1.381.81E-0222252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)1.922.28E-0522252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)2.203.33E-0522252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)2.662.72E-0722252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.104.99E-0223895517
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.127.43E-0323895517
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.219.04E-0323895517

Compile date 09-07-2016© MuScle project