MuScle-logoMuScle - Molecule ID B0131

geneABC-1, ABCA1, ABC1
nameATP-binding cassette, sub-family A (ABC1), member 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ABCA1_HUMANO95477ENSG0000016502919Hs.659274205400, 600046, 604091

Functions and classifications

GOC:cell surface, C:Golgi apparatus, C:integral component of plasma membrane, C:membrane raft, C:phagocytic vesicle, F:anion transmembrane transporter activity, F:apolipoprotein A-I receptor activity, F:ATP binding, F:ATPase activity, F:cholesterol binding, F:cholesterol transporter activity, F:phospholipid binding, F:phospholipid transporter activity, P:ATP catabolic process, P:cellular lipid metabolic process, P:cellular response to cholesterol, P:cellular response to lipopolysaccharide, P:cellular response to retinoic acid, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol metabolic process, P:endosomal transport, P:G-protein coupled receptor signaling pathway, P:high-density lipoprotein particle assembly, P:interleukin-1 beta secretion, P:intracellular cholesterol transport, P:lipoprotein metabolic process, P:lysosome organization, P:negative regulation of cholesterol storage, P:negative regulation of macrophage derived foam cell differentiation, P:peptide secretion, P:phagocytosis, engulfment, P:phospholipid efflux, P:phospholipid homeostasis, P:phospholipid translocation, P:platelet dense granule organization, P:positive regulation of cAMP biosynthetic process, P:positive regulation of cholesterol efflux, P:protein lipidation, P:regulation of Cdc42 protein signal transduction, P:response to drug, P:response to laminar fluid shear stress, P:response to low-density lipoprotein particle, P:response to nutrient, P:reverse cholesterol transport, P:ion transmembrane transport, "C:Golgi apparatus, C:integral to plasma membrane, P:response to low-density lipoprotein particle stimulus
UniProtAtherosclerosis, ATP-binding, Cholesterol metabolism, Complete proteome, Disease mutation, Disulfide bond, Glycoprotein, Lipid metabolism, Lipoprotein, Membrane, Nucleotide-binding, Palmitate, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Steroid metabolism, Sterol metabolism, Transmembrane, Transmembrane helix, Transport
PADBTP: transport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)1.251.55E-0220136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)1.290.0022963420136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_24_month_follow-up) (Multiple sclerosis)1.220.0472898220136355
Exp21346816Homo sapiens12Blood MS (Multiple sclerosis)0.630.03052221346816
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_12_month_follow-up) (Multiple sclerosis)1.390.0226289721886806
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.371.66E-0722252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.661.40E-0322252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.752.53E-0422252466
Exp22491253Homo sapiens7Blood RRMS_(High_Sema4A) (Multiple sclerosis)0.530.0492701222491253

Compile date 09-07-2016© MuScle project