MuScle-logoMuScle - Molecule ID B0129

geneAPOBEC3G, MDS019
nameDNA dC->dU-editing enzyme APOBEC-3G
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ABC3G_HUMANQ9HC16ENSG0000023971360489Hs.660143607113

Functions and classifications

GOC:apolipoprotein B mRNA editing enzyme complex, C:cytoplasmic mRNA processing body, C:cytosol, C:mitochondrion, F:cytidine deaminase activity, F:deoxycytidine deaminase activity, F:protein homodimerization activity, F:RNA binding, F:zinc ion binding, P:base conversion or substitution editing, P:defense response to virus, P:DNA cytosine deamination, P:innate immune response, P:negative regulation of single stranded viral RNA replication via double stranded DNA intermediate, P:negative regulation of transposition, P:positive regulation of defense response to virus by host, P:viral process, "F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines, P:metabolic process", F:metal ion binding, P:negative regulation of retroviral genome replication, P:viral reproduction, P:virus-host interaction, F:zinc ion binding", F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines, P:metabolic process
UniProt3D-structure, Alternative splicing, Antiviral defense, Complete proteome, Cytoplasm, Host-virus interaction, Hydrolase, Immunity, Innate immunity, Metal-binding, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Ubl conjugation, Zinc, Lipoprotein
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)1.191.66E-0220136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_24_month_follow-up) (Multiple sclerosis)0.730.0115509520136355
Exp20921521Homo sapiens10Blood PPMS_(PRF1_gene_Risk_haplotype) (Multiple sclerosis)0.610.00668120921521
Exp21216829Homo sapiens8BloodCD8+RRMS_(CD8+) (Multiple sclerosis)0.260.036548321216829
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)1.535.97E-0321886806
Exp22252466AHomo sapiens13BloodCD34- HPCRRMS_SPMS (Multiple sclerosis)0.776.96E-0322252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.578.51E-0522252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.643.09E-0422252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.431.65E-0223895517

Compile date 09-07-2016© MuScle project