MuScle-logoMuScle - Molecule ID B0124

geneAPOBEC3A
nameProbable C->U editing enzyme APOBEC-3A
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ABC3A_HUMANP31941ENSG00000128383|ENSG00000262156100913187Hs.226307607109

Functions and classifications

GOC:cytoplasm, C:nucleus, F:cytidine deaminase activity, F:deoxycytidine deaminase activity, F:zinc ion binding, P:cellular response to xenobiotic stimulus, P:clearance of foreign intracellular DNA by conversion of DNA cytidine to uridine, P:defense response to virus, P:DNA cytosine deamination, P:DNA demethylation, P:innate immune response, P:negative regulation of transposition, P:negative regulation of viral genome replication, "F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines, P:metabolic process", F:metal ion binding
UniProt3D-structure, Alternative initiation, Antiviral defense, Complete proteome, Cytoplasm, Direct protein sequencing, Hydrolase, Immunity, Innate immunity, Metal-binding, Nucleus, Polymorphism, Reference proteome, Zinc
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)2.612.56E-1120136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)1.980.0000029420136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_2_days_follow-up) (Multiple sclerosis)1.300.018536420136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_24_month_follow-up) (Multiple sclerosis)1.650.0014243420136355
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_12_month_follow-up) (Multiple sclerosis)3.070.0085853521886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)3.927.83E-0421886806
Exp22252466AHomo sapiens13BloodCD34+ HPCRRMS_SPMS (Multiple sclerosis)1.530.015094222252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.031.33E-0822252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.072.72E-1122252466
Exp22491253Homo sapiens7Blood RRMS_(High_Sema4A) (Multiple sclerosis)0.540.0185149622491253
Exp24850724Homo sapiens12Blood CIS (Multiple sclerosis)0.350.0000340624850724

Compile date 09-07-2016© MuScle project