MuScle-logoMuScle - Molecule ID B0101

geneAAK1
nameAP2 associated kinase 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGene
AAK1_HUMANQ2M2I8ENSG0000011597722848Hs.468878

Functions and classifications

GOC:cell leading edge, C:clathrin-coated vesicle, C:coated pit, C:extrinsic component of plasma membrane, C:terminal bouton, F:AP-2 adaptor complex binding, F:ATP binding, F:Notch binding, F:protein serine/threonine kinase activity, P:endocytosis, P:positive regulation of Notch signaling pathway, P:protein autophosphorylation, P:protein stabilization, P:regulation of clathrin-mediated endocytosis, P:regulation of protein localization, C:clathrin complex, C:extrinsic to plasma membrane, C:terminal button
UniProtAcetylation, Alternative splicing, ATP-binding, Cell membrane, Coated pit, Complete proteome, Endocytosis, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, Polymorphism, Reference proteome, Serine/threonine-protein kinase, Transferase
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)0.704.97E-0220136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)0.733.98E-0220136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)1.911.80E-0320136355
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_12_month_follow-up) (Multiple sclerosis)0.710.0339328321886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)0.562.10E-0421886806
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.901.08E-0222021740
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.621.78E-0522252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.111.41E-0223895517
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.217.74E-0423895517

Compile date 09-07-2016© MuScle project