MuScle-logoMuScle - Molecule ID B0098

geneAADAT, KAT2
nameL-kynurenine/alpha-aminoadipate aminotransferase, mitochondrial precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AADAT_HUMANQ8N5Z0ENSG0000010957651166Hs.529735611754

Functions and classifications

GOC:mitochondrial matrix, F:2-aminoadipate transaminase activity, F:kynurenine-oxoglutarate transaminase activity, F:pyridoxal phosphate binding, P:2-oxoglutarate metabolic process, P:biosynthetic process, P:glutamate metabolic process, P:L-lysine catabolic process to acetyl-CoA via saccharopine, P:lysine catabolic process, P:tryptophan catabolic process, P:tryptophan catabolic process to kynurenine, F:catalytic activity, C:mitochondrion, F:transaminase activity
UniProt3D-structure, Acetylation, Alternative splicing, Aminotransferase, Complete proteome, Mitochondrion, Polymorphism, Pyridoxal phosphate, Reference proteome, Transferase, Transit peptide
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_12_month_follow-up) (Multiple sclerosis)1.140.032467221886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1b_3_month_follow-up) (Multiple sclerosis)1.130.0454571921886806
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.971.19E-0222021740
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)6.631.52E-1422252466

Compile date 09-07-2016© MuScle project