MuScle-logoMuScle - Molecule ID B0091

geneADORA2B
nameAdenosine A2b receptor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AA2BR_HUMANP29275ENSG00000170425136Hs.167046600446

Functions and classifications

GOC:integral component of plasma membrane, F:G-protein coupled adenosine receptor activity, P:activation of adenylate cyclase activity, P:activation of MAPK activity, P:adenylate cyclase-activating G-protein coupled receptor signaling pathway, P:cellular defense response, P:cellular response to extracellular stimulus, P:excretion, P:G-protein coupled receptor signaling pathway, P:JNK cascade, P:positive regulation of cGMP biosynthetic process, P:positive regulation of chemokine production, P:positive regulation of chronic inflammatory response to non-antigenic stimulus, P:positive regulation of guanylate cyclase activity, P:positive regulation of interleukin-6 production, P:positive regulation of mast cell degranulation, P:positive regulation vascular endothelial growth factor production, P:relaxation of vascular smooth muscle, C:integral component of membrane, C:plasma membrane, F:G-protein coupled receptor activity, P:positive regulation of cAMP biosynthetic process, C:cell surface, C:integral to plasma membrane, P:negative regulation of cell proliferation, P:negative regulation of collagen biosynthetic process, P:positive regulation of cell proliferation, P:positive regulation of norepinephrine secretion, P:positive regulation of steroid biosynthetic process, P:positive regulation of vasodilation, P:regulation of angiogenesis, C:integral to membrane
UniProtCell membrane, Complete proteome, Disulfide bond, G-protein coupled receptor, Glycoprotein, Lipoprotein, Membrane, Palmitate, Receptor, Reference proteome, Transducer, Transmembrane, Transmembrane helix
PADBRCP: receptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.362.55E-0222021740
Exp22252466AHomo sapiens13BloodCD34+ HPCRRMS_SPMS (Multiple sclerosis)0.750.043610222252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.658.23E-0322252466

Compile date 09-07-2016© MuScle project