MuScle-logoMuScle - Molecule ID B0090

geneADORA2A, ADORA2, HA2AR
nameAdenosine A2a receptor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AA2AR_HUMANP29274ENSG00000128271135Hs.197029102776

Functions and classifications

GOC:asymmetric synapse, C:axolemma, C:dendrite, C:endomembrane system, C:integral component of plasma membrane, C:neuronal cell body, C:postsynaptic density, C:postsynaptic membrane, C:presynaptic active zone, C:presynaptic membrane, F:G-protein coupled adenosine receptor activity, P:activation of adenylate cyclase activity, P:apoptotic process, P:astrocyte activation, P:blood circulation, P:blood coagulation, P:cAMP biosynthetic process, P:cell-cell signaling, P:cellular defense response, P:central nervous system development, P:eating behavior, P:inflammatory response, P:locomotory behavior, P:negative regulation of alpha-beta T cell activation, P:negative regulation of cell proliferation, P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, P:negative regulation of inflammatory response, P:negative regulation of locomotion, P:negative regulation of neuron apoptotic process, P:negative regulation of protein kinase activity, P:negative regulation of vascular permeability, P:neuron projection morphogenesis, P:neurotrophin TRK receptor signaling pathway, P:phagocytosis, P:positive regulation of acetylcholine secretion, neurotransmission, P:positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway, P:positive regulation of apoptotic signaling pathway, P:positive regulation of circadian sleep/wake cycle, sleep, P:positive regulation of glutamate secretion, P:positive regulation of protein secretion, P:positive regulation of renal sodium excretion, P:positive regulation of synaptic transmission, GABAergic, P:positive regulation of synaptic transmission, glutamatergic, P:positive regulation of urine volume, P:prepulse inhibition, P:protein kinase C-activating G-protein coupled receptor signaling pathway, P:regulation of calcium ion transport, P:regulation of excitatory postsynaptic membrane potential, P:regulation of inhibitory postsynaptic membrane potential, P:regulation of mitochondrial membrane potential, P:regulation of norepinephrine secretion, P:regulation of synaptic plasticity, P:regulation of transcription, DNA-templated, P:response to amphetamine, P:response to caffeine, P:response to drug, P:sensory perception, P:synaptic transmission, cholinergic, P:synaptic transmission, dopaminergic, P:synaptic transmission, glutamatergic, P:vasodilation, C:integral component of membrane, P:adenylate cyclase-activating G-protein coupled receptor signaling pathway, P:positive regulation of cAMP biosynthetic process, F:gastric inhibitory peptide receptor activity, P:neurotransmitter transport, C:Golgi membrane, C:integral to plasma membrane, C:intermediate filament, C:intracellular organelle part, P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway, P:nerve growth factor receptor signaling pathway, P:positive regulation of acetylcholine secretion, P:regulation of transcription, DNA-dependent, C:integral to membrane
UniProt3D-structure, Cell membrane, Complete proteome, Disulfide bond, G-protein coupled receptor, Glycoprotein, Membrane, Polymorphism, Receptor, Reference proteome, Transducer, Transmembrane, Transmembrane helix, Ubl conjugation
PADBRCP: receptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)0.893.20E-0220136355
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.381.06E-0422252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.452.61E-0322252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.411.91E-0523895517
Exp24850724Homo sapiens12Blood CIS (Multiple sclerosis)1.580.0211631124850724

Compile date 09-07-2016© MuScle project