MuScle-logoMuScle - Molecule ID B0089

geneADORA1
nameAdenosine A1 receptor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AA1R_HUMANP30542ENSG00000163485134Hs.77867102775

Functions and classifications

GOC:asymmetric synapse, C:axolemma, C:basolateral plasma membrane, C:dendrite, C:endomembrane system, C:endoplasmic reticulum, C:integral component of plasma membrane, C:neuronal cell body, C:postsynaptic density, C:postsynaptic membrane, C:presynaptic active zone, C:presynaptic membrane, C:terminal bouton, F:G-protein coupled adenosine receptor activity, F:phospholipase C activity, F:purine nucleoside binding, P:activation of MAPKK activity, P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, P:apoptotic signaling pathway, P:cell-cell signaling, P:cognition, P:detection of temperature stimulus involved in sensory perception of pain, P:inflammatory response, P:lipid catabolic process, P:negative regulation of acute inflammatory response, P:negative regulation of apoptotic process, P:negative regulation of blood pressure, P:negative regulation of cardiac muscle contraction, P:negative regulation of cell proliferation, P:negative regulation of circadian sleep/wake cycle, non-REM sleep, P:negative regulation of glutamate secretion, P:negative regulation of heart contraction, P:negative regulation of hormone secretion, P:negative regulation of leukocyte migration, P:negative regulation of lipid catabolic process, P:negative regulation of mucus secretion, P:negative regulation of neurotrophin production, P:negative regulation of renal sodium excretion, P:negative regulation of synaptic transmission, GABAergic, P:negative regulation of synaptic transmission, glutamatergic, P:negative regulation of vasodilation, P:nervous system development, P:phagocytosis, P:positive regulation of blood pressure, P:positive regulation of epidermal growth factor-activated receptor activity, P:positive regulation of nucleoside transport, P:positive regulation of peptide secretion, P:positive regulation of potassium ion transport, P:positive regulation of protein dephosphorylation, P:protein targeting to membrane, P:regulation of excitatory postsynaptic membrane potential, P:regulation of glomerular filtration, P:regulation of respiratory gaseous exchange by neurological system process, P:regulation of synaptic plasticity, P:relaxation of vascular smooth muscle, P:response to hypoxia, P:temperature homeostasis, C:integral component of membrane, C:integral to plasma membrane, C:terminal button, C:integral to membrane
UniProtAlternative splicing, Cell membrane, Complete proteome, Disulfide bond, G-protein coupled receptor, Glycoprotein, Lipoprotein, Membrane, Palmitate, Polymorphism, Receptor, Reference proteome, Transducer, Transmembrane, Transmembrane helix
PADBRCP: receptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_1_day_follow-up) (Multiple sclerosis)0.693.29E-0217467740
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)0.708.38E-0320136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_24_month_follow-up) (Multiple sclerosis)0.740.0441715220136355
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.861.72E-0222252466

Compile date 09-07-2016© MuScle project