MuScle-logoMuScle - Molecule ID B0081

geneA2M, CPAMD5, FWP007
nameAlpha-2-macroglobulin precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
A2MG_HUMANP01023ENSG000001758992Hs.212838103950

Functions and classifications

GOC:cytosol, C:extracellular space, C:extracellular vesicular exosome, C:platelet alpha granule lumen, F:interleukin-1 binding, F:serine-type endopeptidase inhibitor activity, F:tumor necrosis factor binding, P:blood coagulation, intrinsic pathway, P:negative regulation of complement activation, lectin pathway, P:platelet activation, P:platelet degranulation, P:regulation of small GTPase mediated signal transduction, P:small GTPase mediated signal transduction, P:stem cell differentiation, F:endopeptidase inhibitor activity, P:negative regulation of endopeptidase activity, P:stem cell differentiation
UniProt3D-structure, Bait region, Complete proteome, Direct protein sequencing, Disulfide bond, Glycoprotein, Isopeptide bond, Polymorphism, Protease inhibitor, Reference proteome, Secreted, Serine protease inhibitor, Signal, Thioester bond
PADBINH: inhibitor (protease, kinase, other enzymes, pathways)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.652.43E-0422252466
Exp22491253Homo sapiens7Blood RRMS_(High_Sema4A) (Multiple sclerosis)5.040.0223528222491253
Exp22491253Homo sapiens7Blood RRMS_(Low_Sema4A) (Multiple sclerosis)0.320.006845722491253

Compile date 09-07-2016© MuScle project