MuScle-logoMuScle - Molecule ID B0070

geneA1A, SERPINA1, AAT
nameAlpha-1-antitrypsin precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
A1AT_HUMANP01009ENSG000001972495265Hs.525557107400, 613490

Functions and classifications

GOC:endoplasmic reticulum, C:extracellular space, C:platelet alpha granule lumen, C:proteinaceous extracellular matrix, F:serine-type endopeptidase inhibitor activity, P:acute-phase response, P:platelet activation, P:platelet degranulation, P:regulation of proteolysis
UniProt3D-structure, Acute phase, Alternative splicing, Blood coagulation, Complete proteome, Direct protein sequencing, Endoplasmic reticulum, Extracellular matrix, Glycoprotein, Hemostasis, Polymorphism, Protease inhibitor, Reference proteome, Secreted, Serine protease inhibitor, Signal
PADBINH: inhibitor (protease, kinase, other enzymes, pathways)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_1_day_follow-up) (Multiple sclerosis)1.464.41E-0217467740
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)1.150.0218324520136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_24_month_follow-up) (Multiple sclerosis)1.250.0039928520136355
Exp21216829Homo sapiens8BloodCD8+RRMS_(CD8+) (Multiple sclerosis)0.060.0012289421216829
Exp21216829Homo sapiens8BloodCD8+RRMS_(CD8+) (Multiple sclerosis)0.490.0256961221216829
Exp21346816Homo sapiens12Blood MS (Multiple sclerosis)0.610.02956921346816
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.443.09E-0422021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.554.45E-0522021740
Exp22252466AHomo sapiens13BloodCD34- HPCRRMS_SPMS (Multiple sclerosis)0.646.46E-0322252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.034.88E-1322252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)0.613.34E-0323895517
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)0.655.12E-0323895517

Compile date 09-07-2016© MuScle project