MoCadb-logoMoCadb - Study ID Exp26175278d

PubMed ID26175278
AuthorsYin X(1), Zhang Y(2), Guo S(3), Jin H(2), Wang W(3), Yang P(1).
TitleLarge scale systematic proteomic quantification from non-metastatic to metastatic colorectal cancer.
JournalSci Rep. 2015 Jul 15;5:12120.
AbstractA systematic proteomic quantification of formalin-fixed, paraffin-embedded (FFPE) colorectal cancer tissues from stage I to stage IIIC was performed in large scale. 1017 proteins were identified with 338 proteins in quantitative changes by label free method, while 341 proteins were quantified with significant expression changes among 6294 proteins by iTRAQ method. We found that proteins related to migration expression increased and those for binding and adherent decreased during the colorectal cancer development according to the gene ontology (GO) annotation and ingenuity pathway analysis (IPA). The integrin alpha 5 (ITA5) in integrin family was focused, which was consistent with the metastasis related pathway. The expression level of ITA5 decreased in metastasis tissues and the result has been further verified by Western blotting. Another two cell migration related proteins vitronectin (VTN) and actin-related protein (ARP3) were also proved to be up-regulated by both mass spectrometry (MS) based quantification results and Western blotting. Up to now, our result shows one of the largest dataset in colorectal cancer proteomics research. Our strategy reveals a disease driven omics-pattern for the metastasis colorectal cancer.

Sample characteristics

SpeciesTissue / SourceDiseaseNDetection methodSample
Homo sapienscolon_rectumCRC (Stage IIIC)17LC-MS/MSDem26175278a, Dem26175278e

Sample description and preparation

N (case)8
N (control)9
Disease (case)CRC (Stage IIIC)
Disease (control)Stage I
Preparation specific methodiTRAQ-labelling
Digestin-solution digestion, Trypsin

Sample analysis

Software thresholdP<0.05, fold change>1.5

Molecule list

Molecule IDextExternal IDGeneNameSource accRegulation (case/control)Scores
A0280 1433E_HUMANYWHAE14-3-3 protein epsilonYWHAEratio: 2.99577268
A0361 1433Z_HUMANYWHAZ14-3-3 protein zeta/deltaYWHAZratio: 3.421985626
A5622 6PGD_HUMANPGD, PGDH6-phosphogluconate dehydrogenase, decarboxylatingPGDratio: 1.384372035
A5625 A1AG1_HUMANORM1, AGP1, ORM2Alpha-1-acid glycoprotein 1 precursorORM1ratio: 4.042978684
A8369 A1AT_HUMANA1A, SERPINA1, AATAlpha-1-antitrypsin precursorSERPINA1ratio: 2.739854256
A1177 A2MG_HUMANA2M, CPAMD5, FWP007Alpha-2-macroglobulin precursorA2Mratio: 0.853452285
A8381 AACT_HUMANSERPINA3, AACT, GIG24Alpha-1-antichymotrypsin precursorSERPINA3ratio: 5.079947949
A5657 ACADV_HUMANACADVL, VLCADAcyl-CoA dehydrogenase, very-long-chain specific, mitochondrial precursorACADVLratio: 3.082459291
A5670 ACOC_HUMANACO1, IRP1, IREB1Iron-responsive element binding protein 1ACO1ratio: 1.30955565
A5696 ACSL5_HUMANACSL5, ACS5, FACL5Long-chain-fatty-acid--CoA ligase 5ACSL5ratio: 1.386837006
A2341 ACTN1_HUMANACTN1Alpha-actinin 1ACTN1ratio: 1.299941659
A2344 ACTN4_HUMANACTN4Alpha-actinin 4ACTN4ratio: 1.145481666
A204A AEBP1_HUMANAEBP1, ACLPAdipocyte enhancer-binding protein 1AEBP1ratio: 1.820569356
A0849 AHNK_HUMANAHNAK, PM227Neuroblast differentiation associated protein AHNAKAHNAKratio: 0.855297744
A3781 AIFM1_HUMANPDCD8, AIFM1, AIFProgrammed cell death protein 8, mitochondrial precursorAIFM1ratio: 2.156063001
A5750 AK1A1_HUMANAKR1A1, ALDR1, ALRAlcohol dehydrogenase [NADP]AKR1A1ratio: 1.693675001
A5751 AK1BA_HUMANAKR1B10, AKR1B11Aldo-keto reductase family 1 member B10AKR1B10ratio: 12.01083914
A0802 AKA12_HUMANAKAP12, AKAP250A-kinase anchor protein 12AKAP12ratio: 1.314118346
B0534 AKTS1_HUMANAKT1S1, PRAS40Proline-rich AKT1 substrate 1IL4I1ratio: 1.062731743
A3585 AL1A1_HUMANALDH1A1, ALDC, ALDH1Aldehyde dehydrogenase 1A1ALDH1A1ratio: 2.263340672
A3599 AL1B1_HUMANALDH1B1, ALDH5, ALDHXAldehyde dehydrogenase X, mitochondrialALDH1B1ratio: 1.57147336
A5766 AL4A1_HUMANALDH4A1, ALDH4, P5CDHDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursorALDH4A1ratio: 0.842581073
A1581 ALBU_HUMANALB, GIG20, GIG42Serum albumin precursorALBratio: 1.059584022
A3598 ALDH2_HUMANALDH2, ALDMAldehyde dehydrogenase, mitochondrial precursorALDH2ratio: 2.996134996
A5788 AMACR_HUMANAMACRAlpha-methylacyl-CoA racemaseAMACRratio: 1.032998284
A5797 AMPL_HUMANLAP3, LAPEP, PEPSCytosol aminopeptidaseLAP3ratio: 0.989836236
A8384 ANT3_HUMANAT3, SERPINC1, PRO0309Antithrombin-III precursorSERPINC1ratio: 2.286439339
A0647 ANXA1_HUMANANXA1, ANX1, LPC1Annexin A1ANXA1ratio: 2.143741966
A0537 ANXA2_HUMANANXA2, ANX2, ANX2L4Annexin A2ANXA2ratio: 2.3948644
A8385 ANXA3_HUMANANXA3, ANX3Annexin A3ANXA3ratio: 2.186673959
A4575 ANXA4_HUMANANXA4, PIG28, ANX4Annexin A4ANXA4ratio: 2.840696653
A4576 ANXA5_HUMANANXA5, ANX5, ENX2Annexin A5ANXA5ratio: 1.57565399
A0029 ANXA6_HUMANANXA6, ANX6Annexin A6ANXA6ratio: 1.397777001
A5813 AOC3_HUMANAOC3, VAP1Membrane copper amine oxidaseAOC3ratio: 0.595992307
A3672 AOFA_HUMANMAOAAmine oxidase [flavin-containing] AMAOAratio: 1.588995655
B0829 APC15_HUMANANAPC15, HSPC020Uncharacterized protein C11ORF51NUMA1ratio: 0.800751527
A5815 APEX1_HUMANAPEX1, APE, APEXDNA-(apurinic or apyrimidinic site) lyaseAPEX1ratio: 1.752864321
A1552 APOA1_HUMANAPOA1, A175PApolipoprotein A-I precursorAPOA1ratio: 3.380984743
A1714 APOB_HUMANAPOBApolipoprotein B-100 precursorAPOBratio: 1.421039025
A1176 APOE_HUMANAPOEApolipoprotein E precursorAPOEratio: 3.64278992
A5817 APT_HUMANAPRTAdenine phosphoribosyltransferaseAPRTratio: 1.430217981
A0455 ARF1_HUMANARF1ADP-ribosylation factor 1ARF1ratio: 4.411100388
A8672 ARP21_HUMANARPP21, ARPP-21, TARPPcAMP-regulated phosphoprotein 21PDCD6IPratio: 1.04505227
A0233 ARPC2_HUMANARPC2, ARC34, PRO2446ARP2/3 complex 34 kDa subunitARPC2ratio: 1.723260323
A0231 ARPC4_HUMANARPC4, ARC20, ARPC4-TTLL3Actin-related protein 2/3 complex subunit 4ARPC4ratio: 1.484986027
A5828 ARY1_HUMANNAT1, AAC1Arylamine N-acetyltransferase 1ASAH1ratio: 1.548979998
A5840 ASPH_HUMANASPHJunctinASPHratio: 2.523992976
A5842 ASSY_HUMANASS1, ASSArgininosuccinate synthaseASS1ratio: 1.575890661
A0344 AT1B1_HUMANATP1B1, ATP1BSodium/potassium-transporting ATPase beta-1 chainATP1B1ratio: 1.437486649
A0387 ATP5H_HUMANATP5H, My032ATP synthase D chain, mitochondrialATP5Hratio: 1.833760341
A0377 ATPA_HUMANATP5A1, ATP5A, ATP5AL2ATP synthase alpha chain, mitochondrial precursorATP5A1ratio: 1.187405348
A0378 ATPB_HUMANATP5B, ATPMB, ATPSBATP synthase beta chain, mitochondrial precursorATP5Bratio: 0.759628375
A4618 CAD17_HUMANCDH17Cadherin-17CDH17ratio: 0.645448784
A5964 CAH2_HUMANCA2Carbonic anhydrase 2CA2ratio: 1.847971638
A1609 CALR_HUMANCALR, CRTCCalreticulin precursorCALRratio: 1.283169985
A0452 CALX_HUMANCANXCalnexin precursorCANXratio: 1.89610362
A0317 CAN1_HUMANCAPN1, CANPL1, PIG30Calpain 1, large [catalytic] subunitCAPN1ratio: 1.853766004
A267A CAND1_HUMANCAND1, TIP120, TIP120ACullin-associated NEDD8-dissociated protein 1CAND1ratio: 1.443165024
A5981 CATA_HUMANCATCatalaseCATratio: 0.999397198
A5984 CATD_HUMANCTSD, CPSDCathepsin D precursorCTSDratio: 1.217440009
A5995 CBPA3_HUMANCPA3Mast cell carboxypeptidase ACPA3ratio: 0.542938441
A1663 CCR5_HUMANCCR5, CCR-5, CMKBR5C-C chemokine receptor type 5EEF1A1ratio: 2.537002285
A6042 CERU_HUMANCPCeruloplasmin precursorCPratio: 1.130219122
A1602 CFAB_HUMANCFB, BF, BFDComplement factor B precursorCFBratio: 2.012073636
A3550 CH60_HUMANHSPD1, HSP6060 kDa heat shock protein, mitochondrial precursorHSPD1ratio: 1.437486649
B2884 CIB4_HUMANCIB4Calcium and integrin-binding family member 4VDAC2ratio: 1.903506319
A3688 CISY_HUMANCSCitrate synthase, mitochondrial precursorCSratio: 3.989845673
A3211 CKAP4_HUMANCKAP4, P63P63 proteinCKAP4ratio: 1.070847352
A878B CLCA1_HUMANCLCA1, CACC1, HCLCA1Chloride channel, calcium activated, family member 1 precursorCLCA1ratio: 5.057095766
A0119 CLH1_HUMANCLTC, CLH17, CLTCL2Clathrin heavy chain 1CLTCratio: 1.00682801
A9274 CLM1_HUMANCD300LF, UNQ3105, PIGRCMRF35-like molecule 1PIGRratio: 0.230542928
A1276 CLUS_HUMANCLU, APOJ, CLIClusterin precursorCLUratio: 3.341511329
A6078 CMBL_HUMANCMBLCarboxymethylenebutenolidase homologCMBLratio: 2.167695959
A3747 CMC2_HUMANSLC25A13, ARALAR2Calcium-binding mitochondrial carrier protein Aralar2SLC25A13ratio: 2.717748086
A9841 CMGA_HUMANCHGAChromogranin A precursorCHGAratio: 0.297950993
B3213 CNG1O_HUMAN Putative anti-CNG alpha 1 cation channel translation productSORBS2ratio: 0.466803064
A4685 CNN1_HUMANCNN1Calponin H1, smooth muscleCNN1ratio: 0.958963116
A1598 CO3_HUMANC3, CPAMD1Complement C3 precursorC3ratio: 1.448429346
A1410 CO6A1_HUMANCOL6A1Collagen alpha 1(VI) chain precursorCOL6A1ratio: 0.834850192
A1422 CO6A2_HUMANCOL6A2Collagen alpha 2(VI) chain precursorCOL6A2ratio: 0.828153233
A1423 CO6A3_HUMANCOL6A3Collagen alpha 3(VI) chain precursorCOL6A3ratio: 0.966856499
A1628 CO9_HUMANC9Complement component C9 precursorC9ratio: 2.524599989
A2407 COCA1_HUMANCOL12A1, COL12A1LCollagen alpha 1(XII) chain precursorCOL12A1ratio: 0.54992942
A4709 COEA1_HUMANCOL14A1, UNDCollagen alpha-1(XIV) chain precursorCOL14A1ratio: 0.794929226
A4710 COF2_HUMANCFL2Cofilin 2CFL2ratio: 0.674735685
A2102 COPA_HUMANCOPACoatomer alpha subunitCOPAratio: 1.192554474
A897B COPG1_HUMANCOPG, COPG1Coatomer gamma subunitCOPG1ratio: 1.536472003
A6203 CPT1A_HUMANCPT1A, CPT1Carnitine O-palmitoyltransferase I, mitochondrial liver isoformCPT1Aratio: 2.158854286
A205D CRBG3_HUMANCRYBG3Beta/gamma crystallin domain-containing protein 3MYLKratio: 0.665067076
A3555 CSPG2_HUMANVCAN, CSPG2Versican core protein precursorVCANratio: 3.890679757
A0535 DESM_HUMANDES, CSM-7, CSM-6DesminDESratio: 0.903980255
A6308 DHB4_HUMANHSD17B4, EDH17B4Peroxisomal multifunctional enzyme type 2HSD17B4ratio: 1.031578839
A3680 DHE3_HUMANGLUD1, GLUDGlutamate dehydrogenase 1, mitochondrial precursorGLUD1ratio: 1.760059993
A6356 DPEP1_HUMANDPEP1, MDP, RDPMicrosomal dipeptidase precursorDPEP1ratio: 0.942820648
B4617 DRC1_HUMANDRC1, CCDC164UPF0407 protein C2ORF39HADHBratio: 2.317336996
A0133 DYHC1_HUMANDYNC1H1, Dnchc1, DHC1Dynein heavy chain, cytosolicDYNC1H1ratio: 0.980997543
B4764 E400N_HUMANEP400NLEP400 N-terminal-like proteinSHMT2ratio: 3.411301931
A3683 ECHA_HUMANHADHA, HADHTrifunctional enzyme alpha subunit, mitochondrial precursorHADHAratio: 2.523952325
A1968 EF1G_HUMANEEF1G, EF1G, PRO1608Elongation factor 1-gammaEEF1Gratio: 2.895905018
A3804 EF2_HUMANEEF2, EF2Elongation factor 2EEF2ratio: 1.524860343
A370A EFTU_HUMANTUFMElongation factor Tu, mitochondrial precursorTUFMratio: 1.883987308
A1390 EHD4_HUMANEHD4, HCA10, HCA11EH-domain containing protein 4EHD4ratio: 1.867849986
A0243 EIF3A_HUMANEIF3A, EIF3S10Eukaryotic translation initiation factor 3 subunit 10EIF3Aratio: 1.376444658
A376A EIF3B_HUMANEIF3B, EIF3S9Eukaryotic translation initiation factor 3 subunit 9EIF3Bratio: 1.578996022
A385A EIF3L_HUMANEIF3L, EIF3EIP, EIF3S6IPEukaryotic translation initiation factor 3 subunit 6 interacting proteinEIF3Lratio: 1.436240673
A4784 EMIL1_HUMANEMILIN1, EMIEMILIN 1 precursorEMILIN1ratio: 1.452811321
A0816 ENAH_HUMANENAH, MENAEnabled protein homologENAHratio: 0.649364372
A0816 ENAH_HUMANENAH, MENAEnabled protein homologENAHratio: 0.649364372
A2004 ENPL_HUMANHSP90B1, GRP94, TRA1Endoplasmin precursorHSP90B1ratio: 1.147889654
A4316 ENPLL_HUMANHSP90B2P, GRP94B, GRP94P1Heat shock protein 94BTRAP1ratio: 0.831380526
A6436 ERAP1_HUMANERAP1, APPILS, ARTS1Endoplasmic reticulum aminopeptidase 1ERAP1ratio: 0.882925014
A6449 ERO1A_HUMANERO1L, UNQ434/PRO865, ERO1-LERO1-like protein alphaERO1Lratio: 2.123919964
A6455 EST1_HUMANCES1, CES1A1a, CES1A1Carboxylesterase 1A1CES1ratio: 0.313641101
A428B ESYT1_HUMANESYT1, FAM62A, MBC2Extended syntaptotagmin-1ESYT1ratio: 1.752855659
A0326 EZRI_HUMANVIL2, EZREzrinEZRratio: 4.126110077
A6477 F16P1_HUMANFBP1, FBPFructose-1,6-bisphosphatase 1FBP1ratio: 0.994723002
A979B FABPL_HUMANFABP1, FABPLFatty acid-binding protein, liverFABP1ratio: 0.451841762
A4117 FANCC_HUMANFANCC, FAC, FACCFanconi anemia group C proteinPGM5ratio: 0.580199431
A4120 FANCG_HUMANFANCG, XRCC9Fanconi anemia group G proteinVCPratio: 1.784398675
A3584 FAS_HUMANFASN, FASFatty acid synthaseFASNratio: 0.767879744
A9713 FCGBP_HUMANFCGBPIgG Fc binding proteinFCGBPratio: 0.882782718
A1467 FIBA_HUMANFGAFibrinogen alpha/alpha-E chain precursorFGAratio: 1.369107008
A1493 FIBB_HUMANFGBFibrinogen beta chain precursorFGBratio: 1.803346674
A1494 FIBG_HUMANFGG, PRO2061Fibrinogen gamma chain precursorFGGratio: 1.249539693
A1466 FINC_HUMANFN1, FNFibronectinFN1ratio: 0.732286294
A0204 FLNA_HUMANFLNA, FLN, FLN1Filamin AFLNAratio: 0.556876222
A4814 FLNB_HUMANFLNB, FLN3, TAPFilamin-BFLNBratio: 1.044553359
A4815 FLNC_HUMANFLNC, ABPL, FLN2Filamin CFLNCratio: 0.490173598
A0224 FSCN1_HUMANFSCN1, FAN1, HSNFascin 1FSCN1ratio: 1.369664669
A6548 G6PD_HUMANG6PDGlucose-6-phosphate 1-dehydrogenaseG6PDratio: 1.390869657
A6556 GALE_HUMANGALEUDP-glucose 4-epimeraseGALEratio: 2.383332014
A1215 GANAB_HUMANGANAB, G2ANNeutral alpha-glucosidase ABGANABratio: 2.446241935
A0124 GBLP_HUMANGNB2L1, HLC7, PIG21Guanine nucleotide-binding protein beta subunit-like protein 12.3GNB2L1ratio: 1.527866682
A483D GBP1_HUMANGBP1Interferon-induced guanylate-binding protein 1GBP1ratio: 0.544500401
A0419 GELS_HUMANGSNGelsolin precursor, plasmaGSNratio: 0.999065955
A1082 GGT5_HUMANGGT5, GGTLA1Gamma-glutamyltransferase 5 precursorGGT5ratio: 2.228797316
A6600 GLCM_HUMANGBA, GC, GLUCGlucosylceramidase precursorGCratio: 1.936292013
A6621 GMDS_HUMANGMDSGDP-mannose 4,6 dehydrataseGMDSratio: 1.394999027
A9925 GPA33_HUMANGPA33Cell surface A33 antigen precursorGPA33ratio: 1.052584688
A3667 GPDM_HUMANGPD2Glycerol-3-phosphate dehydrogenase, mitochondrial precursorGPD2ratio: 2.327218692
A6643 GPX2_HUMANGPX2Glutathione peroxidase 2GPX2ratio: 0.711453398
A2010 GRP75_HUMANHSPA9, GRP75, HSPA9BStress-70 protein, mitochondrial precursorHSPA9ratio: 2.079193036
A0451 GRP78_HUMANHSPA5, GRP78Heat shock 70kDa protein 5HSPA5ratio: 0.940559765
A1952 GSTK1_HUMANGSTK1, HDCMD47PGlutathione S-transferase, mitochondrialGSTK1ratio: 3.63548402
A1961 GSTP1_HUMANGSTP1, FAEES3, GST3Glutathione S-transferase PGSTP1ratio: 5.885649045
A1741 HBA_HUMANHBA1, HBA2, HBZHemoglobin subunit alphaHBA1ratio: 0.719941417
A1742 HBB_HUMANHBB, beta-globinHemoglobin beta chainHBBratio: 0.426871339
A1841 HBE_HUMANHBE1, HBEHemoglobin epsilon chainHBG1ratio: 1.369413853
A524A HDGF_HUMANHDGF, HMG1L2Hepatoma-derived growth factorHDGFratio: 0.973554154
A021C HEMO_HUMANHPXHemopexin precursorHPXratio: 1.059763134
A1828 HLAG_HUMANHLA-G, HLA-6.0, HLAGHLA class I histocompatibility antigen, alpha chain G precursorHLA-Aratio: 0.431898097
A6733 HMCS2_HUMANHMGCS2Hydroxymethylglutaryl-CoA synthase, mitochondrial precursorHMGCS2ratio: 1.756439686
A0717 HNRPK_HUMANHNRNPK, HNRPKHeterogeneous nuclear ribonucleoprotein KHNRNPKratio: 3.061424335
A3792 HNRPM_HUMANHNRNPM, HNRPM, NAGR1Heterogeneous nuclear ribonucleoprotein MHNRNPMratio: 1.90842096
A0599 HNRPQ_HUMANSYNCRIP, HNRPQ, NSAP1Heterogeneous nuclear ribonucleoprotein QSYNCRIPratio: 2.60803632
A2531 HNRPR_HUMANHNRNPR, HNRPRHeterogeneous nuclear ribonucleoprotein RHNRNPRratio: 2.22057565
A0191 HS90A_HUMANHSP90AA1, HSP90A, HSPC1Heat shock protein HSP 90-alphaHSP90AA1ratio: 2.033687671
A2003 HS90B_HUMANHSP90AB1, HSP90B, HSPC2Heat shock protein 90kDa alpha (cytosolic), class B member 1HSP90AB1ratio: 1.116433978
A2007 HSP71_HUMANHSPA1A, HSPA1B, HSPA1Heat shock 70 kDa protein 1HSPA1Aratio: 2.059459408
A4856 HSPB1_HUMANHSPB1, HSP27, HSP28Heat shock protein beta-1HSPB1ratio: 0.623306215
A4347 HSPB6_HUMANHSPB6Heat-shock protein beta-6HSPB6ratio: 0.431779673
A4348 HSPB7_HUMANHSPB7, CVHSPHeat-shock protein, beta-7HSPB7ratio: 0.704618474
A540D HTR5A_HUMANHEATR5AHEAT repeat-containing protein 5AIGHMratio: 1.236261646
A3663 HXK1_HUMANHK1-tc, HK1-tb, HK1-taHexokinase 1HK1ratio: 1.943925262
A6760 HXK2_HUMANHK2Hexokinase, type IIHK2ratio: 1.858882983
A4350 HYOU1_HUMANHYOU1, GRP170, ORP150Hypoxia up-regulated protein 1 precursorHYOU1ratio: 1.50789698
A1591 IC1_HUMANSERPING1, C1IN, C1NHSerine/cysteine proteinase inhibitor clade G member 1SERPING1ratio: 1.344722668
A3661 IDHC_HUMANIDH1, PICDIsocitrate dehydrogenase [NADP] cytoplasmicIDH1ratio: 1.509716312
A3660 IDHP_HUMANIDH2, IDH, IDPIsocitrate dehydrogenase [NADP], mitochondrial precursorIDH2ratio: 1.79441905
A3206 IKIP_HUMANIKBIP, IKIP, IKIP2Inhibitor of nuclear factor kappa-B kinase-interacting proteinSLC25A3ratio: 1.755284309
A8420 ILEU_HUMANSERPINB1, ELANH2, MNEILeukocyte elastase inhibitorSERPINB1ratio: 1.765673002
A6789 IMDH2_HUMANIMPDH2, IMPD2Inosine-5'-monophosphate dehydrogenase 2IMPDH2ratio: 1.658680678
A3973 IMMT_HUMANIMMT, HMP, PIG4Mitochondrial inner membrane proteinIMMTratio: 1.022432327
A6804 IPYR_HUMANPPA1, IOPPP, PPInorganic pyrophosphatasePPA1ratio: 1.864984314
A0213 IQGA1_HUMANIQGAP1Ras GTPase-activating-like protein IQGAP1IQGAP1ratio: 1.789599022
A1694 ITA1_HUMANITGA1, PELOIntegrin alpha-1ITGA1ratio: 0.871317446
A0474 ITA5_HUMANITGA5, FNRAIntegrin alpha-5 precursorITGA5ratio: 0.377657572
A1528 ITA6_HUMANITGA6Integrin alpha-6GFPT1ratio: 1.595715324
A1693 ITA7_HUMANITGA7, UNQ406/PRO768Integrin alpha-7 precursorITGA7ratio: 0.652651012
A0099 ITB1_HUMANITGB1, FNRB, MDF2Integrin beta-1 precursorITGB1ratio: 0.661657035
A8431 ITIH1_HUMANITIH1, IGHEP1, PRO2769Inter-alpha (globulin) inhibitor H1ITIH1ratio: 1.71806097
A8432 ITIH2_HUMANITIH2, IGHEP2Inter-alpha-trypsin inhibitor heavy chain H2 precursorITIH2ratio: 1.250178655
A8434 ITIH4_HUMANITIH4, IHRP, ITIHL1Inter-alpha-trypsin inhibitor heavy chain H4 precursorITIH4ratio: 1.441666325
A9965 ITLN1_HUMANITLN1, INTL, ITLNIntelectin 1ITLN1ratio: 12.96751626
A615D K1755_HUMAN Hypothetical proteinTGM2ratio: 2.044008056
A3824 K1C10_HUMANKRT10, KPPKeratin, type I cytoskeletal 10KRT10ratio: 0.47768119
A3787 K1C19_HUMANKRT19, K19Keratin, type I cytoskeletal 19KRT19ratio: 2.513657649
A0338 K1C20_HUMANKRT20Keratin, type I cytoskeletal 20KRT20ratio: 2.341413975
A3829 K1C9_HUMANKRT9Keratin, type I cytoskeletal 9KRT9ratio: 0.367580493
A3849 K2C1_HUMANKRT1, KRTAKeratin, type II cytoskeletal 1KRT1ratio: 0.33608527
A3848 K2C7_HUMANKRT7, SCLKeratin, type II cytoskeletal 7KRT7ratio: 2.633945386
A3861 K2C78_HUMANKRT78, K5B, KB40Keratin, type II cytoskeletal 78KRT8ratio: 1.856963039
A1925 K6PL_HUMANPFKLPhosphofructokinase, liverPFKLratio: 2.324090719
A622D KANK2_HUMANKANK2, ANKRD25, MXRA3Ankyrin repeat domain-containing protein 25KANK2ratio: 0.622501036
A2286 KCD12_HUMANKCTD12, PFET1BTB/POZ domain-containing protein KCTD12KCTD12ratio: 1.194545945
A3693 KCRB_HUMANCKB, CKBBCreatine kinase B-typeCKBratio: 0.369043837
A2278 KCTD6_HUMANKCTD6Potassium channel tetramerisation domain containing 6PDHBratio: 1.984534025
A3531 KTN1_HUMANKTN1, CG1, PDIA6KinectinPDIA6ratio: 1.317247311
A3531 KTN1_HUMANKTN1, CG1, PDIA6KinectinKTN1ratio: 0.575174789
A1560 LAMA5_HUMANLAMA5Laminin subunit alpha-5LAMA5ratio: 1.043715199
A1508 LAMB1_HUMANLAMB1Laminin subunit beta-1LAMB1ratio: 0.77998511
A1517 LAMB2_HUMANLAMB2, LAMSLaminin beta-2 chain precursorLAMB2ratio: 1.241146326
A1518 LAMC1_HUMANLAMC1, LAMB2Laminin gamma-1 chain precursorLAMC1ratio: 0.975913266
A0370 LDHA_HUMANLDHA, PIG19L-lactate dehydrogenase A chainLDHAratio: 2.595868746
A651D LEG4_HUMANLGALS4Galectin-4LGALS4ratio: 1.459999005
A4004 LETM1_HUMANLETM1Leucine zipper-EF-hand containing transmembrane protein 1, mitochondrialLETM1ratio: 1.691466649
A4941 LG3BP_HUMANLGALS3BP, M2BPGalectin-3-binding protein precursorLGALS3BPratio: 4.301510334
A0430 LMNB1_HUMANLMNB1, LMN2, LMNBLamin B1LMNB1ratio: 0.680740356
A2492 LMNB2_HUMANLMNB2, LMN2Lamin B2LMNB2ratio: 0.695212245
A665D LMO7_HUMANLMO7, FBX20, FBXO20LIM domain only protein 7LMO7ratio: 1.189008018
A3999 LPPRC_HUMANLRPPRC, LRP130Leucine-rich PPR-motif containing proteinLRPPRCratio: 1.472896298
B9054 LRC38_HUMANLRRC38Leucine-rich repeat-containing protein 38EPRSratio: 1.410484672
A4951 LUM_HUMANLUM, LDC, SLRR2DLumican precursorLUMratio: 2.344791253
A6929 LYAG_HUMANGAALysosomal alpha-glucosidase precursorGAAratio: 0.984257698
A6992 MDHC_HUMANMDH1, MDHAMalate dehydrogenase, cytoplasmicMDH1ratio: 0.795727173
A3696 MDHM_HUMANMDH2Malate dehydrogenase, mitochondrial precursorMDH2ratio: 5.596489906
A1655 MMP9_HUMANMMP9, CLG4BMatrix metalloproteinase-9MMP9ratio: 0.380088667
B9897 MOT8_HUMANSLC16A2, MCT8, XPCTSolute carrier family 16, member 2PGK1ratio: 1.872573018
A3949 MTCH2_HUMANMTCH2, MIMP, HSPC032Mitochondrial carrier homolog 2MTCH2ratio: 2.663467646
A7084 MTNB_HUMANAPIP, CGI-29, MMRP19Methylthioribulose-1-phosphate dehydrataseAPIPratio: 3.365081708
A4986 MUC1_HUMANMUC1, PUMMucin-1MUC1ratio: 11.5577873
A4991 MUC18_HUMANMCAM, MUC18Cell surface glycoprotein MUC18 precursorMCAMratio: 0.62484618
A4992 MUC2_HUMANMUC2, mucin, MLPMucin 2 precursorMUC2ratio: 0.740263263
A2616 MUC5A_HUMANMUC5AC, MUC5, MUC 5ACMucin 5ACCCT4ratio: 2.352345705
A156C MVP_HUMANMVP, LRPMajor vault proteinMVPratio: 2.807637691
A2331 MYH11_HUMANMYH11, SMMHCMyosin heavy chain, smooth muscle isoformMYH11ratio: 0.404597511
A3962 MYH14_HUMANMYH14, FP17425Myosin-14MYH14ratio: 0.492461959
A3166 MYH9_HUMANMYH9Myosin heavy chain 9, non-muscleMYH9ratio: 1.554926355
A4049 MYL6_HUMANMYL6, MLC3nm, LC17AMyosin light polypeptide 6MYL6ratio: 0.373266061
A166C MYL9_HUMANMYL9, MLC2, MRLC1Myosin regulatory light polypeptide 9MYL9ratio: 0.366730034
A7110 NAMPT_HUMANNAMPT, NAMPTL, PBEFNicotinamide phosphoribosyltransferaseNAMPTratio: 1.840994716
A7119 NB5R1_HUMANCYB5R1, NQO3A2, UNQ3049/PRO9865NADH-cytochrome b5 reductase 1CYB5R1ratio: 3.180598974
A3561 NDUS1_HUMANNDUFS1, PRO1304NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursorNDUFS1ratio: 1.56191965
A3564 NDUS3_HUMANNDUFS3NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialNDUFS3ratio: 1.679180662
A224C NGAL_HUMANLCN2, HNL, NGALNeutrophil gelatinase-associated lipocalin precursorLCN2ratio: 1.193081975
A1585 NID1_HUMANNID1, NIDNidogen-1NID1ratio: 0.747803072
A5008 NID2_HUMANNID2Nidogen-2NID2ratio: 1.123506387
A2536 NUCL_HUMANNCLNucleolinNCLratio: 0.508431365
A3664 ODO1_HUMANOGDH2-oxoglutarate dehydrogenase E1 component, mitochondrial precursorOGDHratio: 2.758179029
A5018 OLFM4_HUMANOLFM4, GW112, UNQ362/PRO698Olfactomedin-4OLFM4ratio: 13.10050996
A7262 P5CS_HUMANALDH18A1, GSAS, P5CSDelta 1-pyrroline-5-carboxylate synthetaseALDH18A1ratio: 1.173823059
A1271 PALLD_HUMANPALLD, CGI-151, MYNPalladinPALLDratio: 0.864182671
A1312 PARP1_HUMANPARP1, ADPRT, PPOLPoly [ADP]-ribose polymerase-1PARP1ratio: 0.584454358
A838A PDCD4_HUMANPDCD4, H731Programmed cell death 4PDCD4ratio: 1.048274438
A1816 PDIA3_HUMANPDIA3, ERP57, ERP60Protein disulfide isomerase A3 precursorPDIA3ratio: 1.471284668
A7340 PDIA4_HUMANPDIA4, ERP70, ERP72Protein disulfide isomerase A4 precursorPDIA4ratio: 0.960970263
A9740 PDLI7_HUMANPDLIM7, ENIGMAEnigma proteinPDLIM7ratio: 0.892200132
A8448 PEDF_HUMANSERPINF1, PEDF, PIG35Pigment epithelium-derived factor precursorSERPINF1ratio: 1.84245038
A7359 PERE_HUMANEPX, EPER, EPOEosinophil peroxidase precursorEPXratio: 0.165791102
A0459 PERI_HUMANPRPH, NEF4, PRPH1PeripherinPRPHratio: 0.323913753
A7361 PERM_HUMANMPOMyeloperoxidase precursorMPOratio: 0.810774505
A1555 PGBM_HUMANHSPG2Basement membrane-specific heparan sulfate proteoglycan core proteinHSPG2ratio: 0.686438342
BC313 PI5PA_HUMANINPP5J, PIB5PA, PIPPPhosphatidylinositol 4,5-bisphosphate 5-phosphatase ASMTNratio: 0.493057231
A1941 PLEC_HUMANPLEC1, PLECPlectinPLECratio: 1.73397398
A5085 PLSI_HUMANPLS1Plastin 1, I isoformPLS1ratio: 1.719041387
A5086 PLSL_HUMANLCP1, PLS2Plastin-2LCP1ratio: 0.843789597
A7447 PNCB_HUMANNAPRT1, FHIP, PP3856Nicotinate phosphoribosyltransferase-like proteinNAPRT1ratio: 4.227047285
A5090 POSTN_HUMANPOSTN, OSF2, OSF-2Periostin, osteoblast specific factorPOSTNratio: 4.139104764
A4370 PPIB_HUMANPPIB, CYPBPeptidyl-prolyl cis-trans isomerase B precursorPPIBratio: 1.37835598
A5096 PRELP_HUMANPRELP, SLRR2A, MST161Prolargin precursorPRELPratio: 2.708963712
A1284 PRKDC_HUMANPRKDC, HYRC, HYRC1DNA-dependent protein kinase catalytic subunitPRKDCratio: 1.207978408
A9534 PRP8_HUMANPRPF8, PRPC8, HPRP8Pre-mRNA-processing-splicing factor 8PRPF8ratio: 1.121381084
A7518 PSA1_HUMANPSMA1, HC2, NUProteasome subunit alpha type 1PSMA1ratio: 1.558235009
A887A PTRF_HUMANPTRF, FKSG13Polymerase I and transcript release factorPTRFratio: 0.626099269
A7558 PUR9_HUMANATIC, PURHBifunctional purine biosynthesis protein PURHATICratio: 1.652450999
A3588 PYGB_HUMANPYGBGlycogen phosphorylase, brain formPYGBratio: 1.082061152
A3676 QCR1_HUMANUQCRC1Ubiquinol-cytochrome C reductase complex core protein I, mitochondrial precursorUQCRC1ratio: 3.127736012
A3677 QCR2_HUMANUQCRC2Cytochrome B-C1 complex subunit 2, mitochondrialUQCRC2ratio: 2.625053723
A0152 RAN_HUMANRAN, ARA24, TC4GTP-binding nuclear protein RANRANratio: 5.741345088
A1136 ROA2_HUMANHNRNPA2B1, HNRPA2B1Heterogeneous nuclear ribonucleoproteins A2/B1HNRNPA2B1ratio: 3.512617747
A3639 RPN1_HUMANRPN1Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 67 kDa subunit precursorRPN1ratio: 0.900012612
A369C RRBP1_HUMANRRBP1Ribosome-binding protein 1RRBP1ratio: 0.656036754
A375C S12A2_HUMANSLC12A2, NKCC1Solute carrier family 12 member 2SLC12A2ratio: 0.574637999
A1597 SAMP_HUMANAPCS, PTX2Serum amyloid P-component precursorAPCSratio: 1.22778964
A463C SBP1_HUMANSELENBP1, SBPSelenium-binding protein 1SELENBP1ratio: 0.852648874
A3770 SCMC1_HUMANSLC25A24, APC1, MCSC1Solute carrier family 25 member 24SLC25A24ratio: 2.098997354
A495C SDPR_HUMANSDPRSerum deprivation response proteinSDPRratio: 0.443946709
BE726 SEBOX_HUMANSEBOX, OG9XHomeobox protein SEBOXVTNratio: 4.555380265
A1014 SFPQ_HUMANSFPQ, PSFSplicing factor, proline-and glutamine-richSFPQratio: 2.242088
A313E SH3L1_HUMANSH3BGRLSH3 domain-binding glutamic acid-rich-like proteinSH3BGRLratio: 0.657120943
A3788 SND1_HUMANSND1, TDRD11Staphylococcal nuclease domain containing protein 1SND1ratio: 2.207576315
A9060 SORCN_HUMANSRISorcinSRIratio: 2.991270701
A8502 SPB5_HUMANSERPINB5, PI5Maspin precursorSERPINB5ratio: 3.671412945
A0010 SPTB2_HUMANSPTBN1, SPTB2, RPL23AP13Spectrin beta chain, brain 1SPTBN1ratio: 0.76486671
A5151 SPTN1_HUMANSPTAN1, SPTA2, NEASSpectrin alpha chain, brainSPTAN1ratio: 0.829085151
A7863 SQRD_HUMANSQRDL, CGI-44, PRO1975Sulfide:quinone oxidoreductase, mitochondrial precursorSQRDLratio: 1.656092008
A0100 SRBS1_HUMANSORBS1, CAP, SH3P12Sorbin and SH3 domain containing 1SORBS1ratio: 0.663810591
A2598 SRRM2_HUMANSRRM2, SRL300, SRM300Serine/arginine repeptitive matrix protein 2SRRM2ratio: 0.809961478
A0719 STAT1_HUMANSTAT1Signal transducer and activator of transcription 1-alpha/betaSTAT1ratio: 0.554836174
A0492 STIP1_HUMANSTIP1Stress-induced-phosphoprotein 1STIP1ratio: 1.215525667
A7900 SUCB2_HUMANSUCLG2Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial precursorSUCLG2ratio: 0.779002686
A7912 SYDC_HUMANDARS, PIG40Aspartyl-tRNA synthetaseDARSratio: 1.53601567
A7915 SYEP_HUMANEPRS, GLNS, PARSBifunctional aminoacyl-tRNA synthetaseQARSratio: 1.071632028
A7922 SYIC_HUMANIARS, PRO0785Isoleucyl-tRNA synthetase, cytoplasmicIARSratio: 0.639854143
A5169 SYNEM_HUMANSYNM, DMN, SYNSyneminSYNMratio: 0.297617564
A5170 SYNP2_HUMANSYNPO2, MYOPODINSynaptopodin 2SYNPO2ratio: 0.577235003
A7933 SYSC_HUMANSARS, SERSSeryl-tRNA synthetase, cytoplasmicSARSratio: 1.23375833
A7941 SYWC_HUMANWARS, IFI53, WRSTryptophanyl-tRNA synthetase, cytoplasmicWARSratio: 0.406956335
A5174 TAGL_HUMANTAGLN, SM22, WS3-10TransgelinTAGLNratio: 0.898151597
A371E TAGL2_HUMANTAGLN2, CDABP0035Transgelin 2TAGLN2ratio: 3.062328736
A3541 TCPA_HUMANTCP1, CCT1, CCTAT-complex protein 1, alpha subunitTCP1ratio: 2.048420707
A3540 TCPB_HUMANCCT2, 99D8.1, CCTBT-complex protein 1, beta subunitCCT2ratio: 2.069898327
A3543 TCPE_HUMANCCT5, CCTE, PNAS-102T-complex protein 1, epsilon subunitCCT5ratio: 1.554277341
A3544 TCPG_HUMANCCT3, CCTG, TRIC5T-complex protein 1, gamma subunitCCT3ratio: 2.09283638
A3539 TCPH_HUMANCCT7, CCTH, NIP7-1T-complex protein 1, eta subunitCCT7ratio: 1.8759257
A3542 TCPQ_HUMANCCT8, CCTQT-complex protein 1, theta subunitCCT8ratio: 2.093797366
A1525 TENA_HUMANTNC, HXBTenascin precursorTNCratio: 0.377394795
A1301 TGFI1_HUMANTGFB1I1, ARA55, Hic-5Transforming growth factor beta 1 induced transcript 1TGFB1I1ratio: 0.89452527
A9106 THIO_HUMANTXN delta 3, TXN, TRDXThioredoxinTXNratio: 2.089356978
A1469 THRB_HUMANF2Prothrombin precursorF2ratio: 2.09133033
A0097 TLN1_HUMANTLN1, TLNTalin 1TLN1ratio: 0.851884981
A127B TR150_HUMANTHRAP3, TRAP150Thyroid hormone receptor-associated protein 3THRAP3ratio: 0.865400851
A1712 TRFL_HUMANLTF, LF, GIG12Lactotransferrin precursorLTFratio: 0.754305641
A8080 TYPH_HUMANTYMP, ECGF1Thymidine phosphorylase precursorTYMPratio: 0.95369037
A2150 U520_HUMANSNRNP200, ASCC3L1, HELIC2U5 small nuclear ribonucleoprotein 200 kDa helicaseSNRNP200ratio: 1.157549341
A8092 UBA1_HUMANUBA1, UBE1, A1S9TUbiquitin-activating enzyme E1UBA1ratio: 2.237785617
A0425 VDAC1_HUMANVDAC1, VDAC, VDAC4Voltage-dependent anion-selective channel protein 1VDAC1ratio: 3.340440591
A5242 VILI_HUMANVIL1, VILVillin 1VIL1ratio: 1.198372682
A0850 VIME_HUMANVIMVimentinVIMratio: 3.522878011
A0098 VINC_HUMANVCLVinculinVCLratio: 0.68601654
A3909 VPS35_HUMANVPS35, MEM3Vacuolar protein sorting-associated protein 35VPS35ratio: 1.375817338
A9151 VWA1_HUMANVWA1, WARPVon Willebrand factor A domain-containing protein 1VWA1ratio: 0.562567294
A1521 VWF_HUMANVWF, F8VWFVon Willebrand factor precursorVWFratio: 0.734335701
A0777 XRCC5_HUMANXRCC5, G22P2, KARP-1X-ray repair cross-complementing protein 5XRCC5ratio: 2.647148967
A0716 XRCC6_HUMANXRCC6, G22P1X-ray repair cross-complementing protein 6XRCC6ratio: 2.183849017
A195A ZA2G_HUMANAZGP1, ZAG, ZNGP1Zinc-alpha-2-glycoprotein precursorAZGP1ratio: 2.351780057
A0429 ACON_HUMANACO2Aconitate hydratase, mitochondrial precursorACO2ratio: 2.119906664
A0340 AT1A1_HUMANATP1A1Sodium/potassium-transporting ATPase alpha-1 chain precursorATP1A1ratio: 1.274537643
BJ443 BL1S5_HUMANBLOC1S5, MUTED, BLOC1S5-TXNDC5Muted protein homologTXNDC5ratio: 1.248207887
A4629 CALD1_HUMANCALD1, CAD, CDMCaldesmonCALD1ratio: 0.706103583
A541A HMGA2_HUMANHMGIC, HMGA2, HMGA2DHigh mobility group protein HMGI-CHMGA2ratio: 1.650678039
A1631 HPT_HUMANHPHaptoglobin precursorHPratio: 2.546899716
A1577 K1C18_HUMANKRT18, CYK18, PIG46Keratin, type I cytoskeletal 18KRT18ratio: 1.731995344
A0778 MAP4_HUMANMAP4Microtubule-associated protein 4MAP4ratio: 0.69792368
A9994 MIME_HUMANOGN, OIF, SLRR3AMimecan precursorOGNratio: 1.139286319
A1004 MYPT1_HUMANPPP1R12A, MBS, MYPT1Protein phosphatase 1 regulatory (inhibitor) subunit 12APPP1R12Aratio: 0.75675414
A757D NUCKS_HUMANNUCKS1, NUCKS, JC7Nuclear ubiquitous casein and cyclin-dependent kinases substrateNUCKS1ratio: 0.926792959
A1733 PDIA1_HUMANP4HB, ERBA2L, PDIProtein disulfide isomerase precursorP4HBratio: 2.409432054
A0325 TENS1_HUMANTNS1, TNSTensin-1TNS1ratio: 0.669713289
A643C TRFE_HUMANTF, PRO1400Serotransferrin precursorTFratio: 0.825932344
A681C VIGLN_HUMANHDLBP, HBP, VGLVigilinHDLBPratio: 1.00674502

Compile date 10-20-2017© .