MoCadb-logoMoCadb - Study ID Exp26175278c

PubMed ID26175278
AuthorsYin X(1), Zhang Y(2), Guo S(3), Jin H(2), Wang W(3), Yang P(1).
TitleLarge scale systematic proteomic quantification from non-metastatic to metastatic colorectal cancer.
JournalSci Rep. 2015 Jul 15;5:12120.
AbstractA systematic proteomic quantification of formalin-fixed, paraffin-embedded (FFPE) colorectal cancer tissues from stage I to stage IIIC was performed in large scale. 1017 proteins were identified with 338 proteins in quantitative changes by label free method, while 341 proteins were quantified with significant expression changes among 6294 proteins by iTRAQ method. We found that proteins related to migration expression increased and those for binding and adherent decreased during the colorectal cancer development according to the gene ontology (GO) annotation and ingenuity pathway analysis (IPA). The integrin alpha 5 (ITA5) in integrin family was focused, which was consistent with the metastasis related pathway. The expression level of ITA5 decreased in metastasis tissues and the result has been further verified by Western blotting. Another two cell migration related proteins vitronectin (VTN) and actin-related protein (ARP3) were also proved to be up-regulated by both mass spectrometry (MS) based quantification results and Western blotting. Up to now, our result shows one of the largest dataset in colorectal cancer proteomics research. Our strategy reveals a disease driven omics-pattern for the metastasis colorectal cancer.

Sample characteristics

SpeciesTissue / SourceDiseaseNDetection methodSample
Homo sapienscolon_rectumCRC (Stage IIIB)14LC-MS/MSDem26175278a, Dem26175278d

Sample description and preparation

N (case)5
N (control)9
Disease (case)CRC (Stage IIIB)
Disease (control)Stage I
Preparation specific methodiTRAQ-labelling
Digestin-solution digestion, Trypsin

Sample analysis

Software thresholdP<0.05, fold change>1.5

Molecule list

Molecule IDextExternal IDGeneNameSource accRegulation (case/control)Scores
A0280 1433E_HUMANYWHAE14-3-3 protein epsilonYWHAEratio: 1.44653368
A0361 1433Z_HUMANYWHAZ14-3-3 protein zeta/deltaYWHAZratio: 1.198421677
A5622 6PGD_HUMANPGD, PGDH6-phosphogluconate dehydrogenase, decarboxylatingPGDratio: 2.65271461
A5625 A1AG1_HUMANORM1, AGP1, ORM2Alpha-1-acid glycoprotein 1 precursorORM1ratio: 3.450702667
A8369 A1AT_HUMANA1A, SERPINA1, AATAlpha-1-antitrypsin precursorSERPINA1ratio: 2.152425686
A1177 A2MG_HUMANA2M, CPAMD5, FWP007Alpha-2-macroglobulin precursorA2Mratio: 1.334784627
A8381 AACT_HUMANSERPINA3, AACT, GIG24Alpha-1-antichymotrypsin precursorSERPINA3ratio: 3.751752297
A5657 ACADV_HUMANACADVL, VLCADAcyl-CoA dehydrogenase, very-long-chain specific, mitochondrial precursorACADVLratio: 2.417225281
A5670 ACOC_HUMANACO1, IRP1, IREB1Iron-responsive element binding protein 1ACO1ratio: 1.565024972
A5696 ACSL5_HUMANACSL5, ACS5, FACL5Long-chain-fatty-acid--CoA ligase 5ACSL5ratio: 0.802911282
A2341 ACTN1_HUMANACTN1Alpha-actinin 1ACTN1ratio: 0.378425529
A2344 ACTN4_HUMANACTN4Alpha-actinin 4ACTN4ratio: 0.630812446
A204A AEBP1_HUMANAEBP1, ACLPAdipocyte enhancer-binding protein 1AEBP1ratio: 2.206317345
A0849 AHNK_HUMANAHNAK, PM227Neuroblast differentiation associated protein AHNAKAHNAKratio: 0.424078703
A3781 AIFM1_HUMANPDCD8, AIFM1, AIFProgrammed cell death protein 8, mitochondrial precursorAIFM1ratio: 1.287958662
A5750 AK1A1_HUMANAKR1A1, ALDR1, ALRAlcohol dehydrogenase [NADP]AKR1A1ratio: 1.51425767
A5751 AK1BA_HUMANAKR1B10, AKR1B11Aldo-keto reductase family 1 member B10AKR1B10ratio: 3.887693008
A0802 AKA12_HUMANAKAP12, AKAP250A-kinase anchor protein 12AKAP12ratio: 0.849039972
B0534 AKTS1_HUMANAKT1S1, PRAS40Proline-rich AKT1 substrate 1IL4I1ratio: 2.502826929
A3585 AL1A1_HUMANALDH1A1, ALDC, ALDH1Aldehyde dehydrogenase 1A1ALDH1A1ratio: 0.795131226
A3599 AL1B1_HUMANALDH1B1, ALDH5, ALDHXAldehyde dehydrogenase X, mitochondrialALDH1B1ratio: 0.904372593
A5766 AL4A1_HUMANALDH4A1, ALDH4, P5CDHDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursorALDH4A1ratio: 0.677223007
A1581 ALBU_HUMANALB, GIG20, GIG42Serum albumin precursorALBratio: 1.363535324
A3598 ALDH2_HUMANALDH2, ALDMAldehyde dehydrogenase, mitochondrial precursorALDH2ratio: 2.189735333
A5788 AMACR_HUMANAMACRAlpha-methylacyl-CoA racemaseAMACRratio: 1.144543747
A5797 AMPL_HUMANLAP3, LAPEP, PEPSCytosol aminopeptidaseLAP3ratio: 0.95831432
A8384 ANT3_HUMANAT3, SERPINC1, PRO0309Antithrombin-III precursorSERPINC1ratio: 2.448191643
A0647 ANXA1_HUMANANXA1, ANX1, LPC1Annexin A1ANXA1ratio: 1.901833932
A0537 ANXA2_HUMANANXA2, ANX2, ANX2L4Annexin A2ANXA2ratio: 2.300205628
A8385 ANXA3_HUMANANXA3, ANX3Annexin A3ANXA3ratio: 1.80848066
A4575 ANXA4_HUMANANXA4, PIG28, ANX4Annexin A4ANXA4ratio: 3.601629655
A4576 ANXA5_HUMANANXA5, ANX5, ENX2Annexin A5ANXA5ratio: 1.419218024
A0029 ANXA6_HUMANANXA6, ANX6Annexin A6ANXA6ratio: 1.299629013
A5813 AOC3_HUMANAOC3, VAP1Membrane copper amine oxidaseAOC3ratio: 0.602165401
A3672 AOFA_HUMANMAOAAmine oxidase [flavin-containing] AMAOAratio: 1.348922551
B0829 APC15_HUMANANAPC15, HSPC020Uncharacterized protein C11ORF51NUMA1ratio: 0.387711336
A5815 APEX1_HUMANAPEX1, APE, APEXDNA-(apurinic or apyrimidinic site) lyaseAPEX1ratio: 1.102557977
A1552 APOA1_HUMANAPOA1, A175PApolipoprotein A-I precursorAPOA1ratio: 4.869221926
A1714 APOB_HUMANAPOBApolipoprotein B-100 precursorAPOBratio: 1.755763372
A1176 APOE_HUMANAPOEApolipoprotein E precursorAPOEratio: 3.269497633
A5817 APT_HUMANAPRTAdenine phosphoribosyltransferaseAPRTratio: 2.456148704
A0455 ARF1_HUMANARF1ADP-ribosylation factor 1ARF1ratio: 5.275882721
A8672 ARP21_HUMANARPP21, ARPP-21, TARPPcAMP-regulated phosphoprotein 21PDCD6IPratio: 0.578540981
A0233 ARPC2_HUMANARPC2, ARC34, PRO2446ARP2/3 complex 34 kDa subunitARPC2ratio: 2.779570659
A0231 ARPC4_HUMANARPC4, ARC20, ARPC4-TTLL3Actin-related protein 2/3 complex subunit 4ARPC4ratio: 2.640015642
A5828 ARY1_HUMANNAT1, AAC1Arylamine N-acetyltransferase 1ASAH1ratio: 1.811936696
A5840 ASPH_HUMANASPHJunctinASPHratio: 0.562934021
A5842 ASSY_HUMANASS1, ASSArgininosuccinate synthaseASS1ratio: 1.509693642
A0344 AT1B1_HUMANATP1B1, ATP1BSodium/potassium-transporting ATPase beta-1 chainATP1B1ratio: 2.664117257
A0387 ATP5H_HUMANATP5H, My032ATP synthase D chain, mitochondrialATP5Hratio: 1.473285675
A0377 ATPA_HUMANATP5A1, ATP5A, ATP5AL2ATP synthase alpha chain, mitochondrial precursorATP5A1ratio: 1.806465029
A0378 ATPB_HUMANATP5B, ATPMB, ATPSBATP synthase beta chain, mitochondrial precursorATP5Bratio: 1.424713691
A4618 CAD17_HUMANCDH17Cadherin-17CDH17ratio: 0.960337102
A5964 CAH2_HUMANCA2Carbonic anhydrase 2CA2ratio: 1.145688335
A1609 CALR_HUMANCALR, CRTCCalreticulin precursorCALRratio: 0.668998043
A0452 CALX_HUMANCANXCalnexin precursorCANXratio: 0.976024866
A0317 CAN1_HUMANCAPN1, CANPL1, PIG30Calpain 1, large [catalytic] subunitCAPN1ratio: 2.176343997
A267A CAND1_HUMANCAND1, TIP120, TIP120ACullin-associated NEDD8-dissociated protein 1CAND1ratio: 1.12821885
A5981 CATA_HUMANCATCatalaseCATratio: 1.230340997
A5984 CATD_HUMANCTSD, CPSDCathepsin D precursorCTSDratio: 1.731210311
A5995 CBPA3_HUMANCPA3Mast cell carboxypeptidase ACPA3ratio: 0.692086399
A1663 CCR5_HUMANCCR5, CCR-5, CMKBR5C-C chemokine receptor type 5EEF1A1ratio: 2.492720326
A6042 CERU_HUMANCPCeruloplasmin precursorCPratio: 1.992800355
A1602 CFAB_HUMANCFB, BF, BFDComplement factor B precursorCFBratio: 2.951580365
A3550 CH60_HUMANHSPD1, HSP6060 kDa heat shock protein, mitochondrial precursorHSPD1ratio: 0.255637472
B2884 CIB4_HUMANCIB4Calcium and integrin-binding family member 4VDAC2ratio: 1.60023133
A3688 CISY_HUMANCSCitrate synthase, mitochondrial precursorCSratio: 2.479792277
A3211 CKAP4_HUMANCKAP4, P63P63 proteinCKAP4ratio: 0.508980741
A878B CLCA1_HUMANCLCA1, CACC1, HCLCA1Chloride channel, calcium activated, family member 1 precursorCLCA1ratio: 3.653974295
A0119 CLH1_HUMANCLTC, CLH17, CLTCL2Clathrin heavy chain 1CLTCratio: 0.529168805
A9274 CLM1_HUMANCD300LF, UNQ3105, PIGRCMRF35-like molecule 1PIGRratio: 1.187601646
A1276 CLUS_HUMANCLU, APOJ, CLIClusterin precursorCLUratio: 1.971709053
A6078 CMBL_HUMANCMBLCarboxymethylenebutenolidase homologCMBLratio: 3.521079064
A3747 CMC2_HUMANSLC25A13, ARALAR2Calcium-binding mitochondrial carrier protein Aralar2SLC25A13ratio: 1.367484013
A9841 CMGA_HUMANCHGAChromogranin A precursorCHGAratio: 0.53081888
B3213 CNG1O_HUMAN Putative anti-CNG alpha 1 cation channel translation productSORBS2ratio: 0.344375272
A4685 CNN1_HUMANCNN1Calponin H1, smooth muscleCNN1ratio: 0.235337402
A1598 CO3_HUMANC3, CPAMD1Complement C3 precursorC3ratio: 2.860471964
A1410 CO6A1_HUMANCOL6A1Collagen alpha 1(VI) chain precursorCOL6A1ratio: 0.756365855
A1422 CO6A2_HUMANCOL6A2Collagen alpha 2(VI) chain precursorCOL6A2ratio: 0.72975868
A1423 CO6A3_HUMANCOL6A3Collagen alpha 3(VI) chain precursorCOL6A3ratio: 0.975747446
A1628 CO9_HUMANC9Complement component C9 precursorC9ratio: 2.811303298
A2407 COCA1_HUMANCOL12A1, COL12A1LCollagen alpha 1(XII) chain precursorCOL12A1ratio: 1.264734666
A4709 COEA1_HUMANCOL14A1, UNDCollagen alpha-1(XIV) chain precursorCOL14A1ratio: 1.126123031
A4710 COF2_HUMANCFL2Cofilin 2CFL2ratio: 0.403690299
A2102 COPA_HUMANCOPACoatomer alpha subunitCOPAratio: 0.715619008
A897B COPG1_HUMANCOPG, COPG1Coatomer gamma subunitCOPG1ratio: 1.038216154
A6203 CPT1A_HUMANCPT1A, CPT1Carnitine O-palmitoyltransferase I, mitochondrial liver isoformCPT1Aratio: 2.062261979
A205D CRBG3_HUMANCRYBG3Beta/gamma crystallin domain-containing protein 3MYLKratio: 0.358670195
A3555 CSPG2_HUMANVCAN, CSPG2Versican core protein precursorVCANratio: 3.106213411
A0535 DESM_HUMANDES, CSM-7, CSM-6DesminDESratio: 0.874265651
A6308 DHB4_HUMANHSD17B4, EDH17B4Peroxisomal multifunctional enzyme type 2HSD17B4ratio: 1.277213593
A3680 DHE3_HUMANGLUD1, GLUDGlutamate dehydrogenase 1, mitochondrial precursorGLUD1ratio: 1.002563278
A6356 DPEP1_HUMANDPEP1, MDP, RDPMicrosomal dipeptidase precursorDPEP1ratio: 1.739049633
B4617 DRC1_HUMANDRC1, CCDC164UPF0407 protein C2ORF39HADHBratio: 1.592408975
A0133 DYHC1_HUMANDYNC1H1, Dnchc1, DHC1Dynein heavy chain, cytosolicDYNC1H1ratio: 0.513809721
B4764 E400N_HUMANEP400NLEP400 N-terminal-like proteinSHMT2ratio: 3.346101602
A3683 ECHA_HUMANHADHA, HADHTrifunctional enzyme alpha subunit, mitochondrial precursorHADHAratio: 1.346130868
A1968 EF1G_HUMANEEF1G, EF1G, PRO1608Elongation factor 1-gammaEEF1Gratio: 2.627290964
A3804 EF2_HUMANEEF2, EF2Elongation factor 2EEF2ratio: 1.396308621
A370A EFTU_HUMANTUFMElongation factor Tu, mitochondrial precursorTUFMratio: 0.622149209
A1390 EHD4_HUMANEHD4, HCA10, HCA11EH-domain containing protein 4EHD4ratio: 1.282821655
A0243 EIF3A_HUMANEIF3A, EIF3S10Eukaryotic translation initiation factor 3 subunit 10EIF3Aratio: 1.179599047
A376A EIF3B_HUMANEIF3B, EIF3S9Eukaryotic translation initiation factor 3 subunit 9EIF3Bratio: 1.557157993
A385A EIF3L_HUMANEIF3L, EIF3EIP, EIF3S6IPEukaryotic translation initiation factor 3 subunit 6 interacting proteinEIF3Lratio: 1.54037567
A4784 EMIL1_HUMANEMILIN1, EMIEMILIN 1 precursorEMILIN1ratio: 0.8651975
A0816 ENAH_HUMANENAH, MENAEnabled protein homologENAHratio: 0.595175634
A0816 ENAH_HUMANENAH, MENAEnabled protein homologENAHratio: 0.595175634
A2004 ENPL_HUMANHSP90B1, GRP94, TRA1Endoplasmin precursorHSP90B1ratio: 0.732462843
A4316 ENPLL_HUMANHSP90B2P, GRP94B, GRP94P1Heat shock protein 94BTRAP1ratio: 0.856479863
A6436 ERAP1_HUMANERAP1, APPILS, ARTS1Endoplasmic reticulum aminopeptidase 1ERAP1ratio: 1.779968659
A6449 ERO1A_HUMANERO1L, UNQ434/PRO865, ERO1-LERO1-like protein alphaERO1Lratio: 1.720123966
A6455 EST1_HUMANCES1, CES1A1a, CES1A1Carboxylesterase 1A1CES1ratio: 0.369247168
A428B ESYT1_HUMANESYT1, FAM62A, MBC2Extended syntaptotagmin-1ESYT1ratio: 1.665955981
A0326 EZRI_HUMANVIL2, EZREzrinEZRratio: 2.443382383
A6477 F16P1_HUMANFBP1, FBPFructose-1,6-bisphosphatase 1FBP1ratio: 0.992842079
A979B FABPL_HUMANFABP1, FABPLFatty acid-binding protein, liverFABP1ratio: 1.69134299
A4117 FANCC_HUMANFANCC, FAC, FACCFanconi anemia group C proteinPGM5ratio: 0.342493773
A4120 FANCG_HUMANFANCG, XRCC9Fanconi anemia group G proteinVCPratio: 1.630619327
A3584 FAS_HUMANFASN, FASFatty acid synthaseFASNratio: 0.575595935
A9713 FCGBP_HUMANFCGBPIgG Fc binding proteinFCGBPratio: 1.223385652
A1467 FIBA_HUMANFGAFibrinogen alpha/alpha-E chain precursorFGAratio: 2.697719336
A1493 FIBB_HUMANFGBFibrinogen beta chain precursorFGBratio: 3.576074322
A1494 FIBG_HUMANFGG, PRO2061Fibrinogen gamma chain precursorFGGratio: 2.57177337
A1466 FINC_HUMANFN1, FNFibronectinFN1ratio: 1.327329318
A0204 FLNA_HUMANFLNA, FLN, FLN1Filamin AFLNAratio: 0.221215367
A4814 FLNB_HUMANFLNB, FLN3, TAPFilamin-BFLNBratio: 1.147773524
A4815 FLNC_HUMANFLNC, ABPL, FLN2Filamin CFLNCratio: 0.217129534
A0224 FSCN1_HUMANFSCN1, FAN1, HSNFascin 1FSCN1ratio: 1.696335991
A6548 G6PD_HUMANG6PDGlucose-6-phosphate 1-dehydrogenaseG6PDratio: 1.929906964
A6556 GALE_HUMANGALEUDP-glucose 4-epimeraseGALEratio: 1.926963369
A1215 GANAB_HUMANGANAB, G2ANNeutral alpha-glucosidase ABGANABratio: 4.074099541
A0124 GBLP_HUMANGNB2L1, HLC7, PIG21Guanine nucleotide-binding protein beta subunit-like protein 12.3GNB2L1ratio: 2.07186234
A483D GBP1_HUMANGBP1Interferon-induced guanylate-binding protein 1GBP1ratio: 0.595676333
A0419 GELS_HUMANGSNGelsolin precursor, plasmaGSNratio: 0.607036511
A1082 GGT5_HUMANGGT5, GGTLA1Gamma-glutamyltransferase 5 precursorGGT5ratio: 1.634942333
A6600 GLCM_HUMANGBA, GC, GLUCGlucosylceramidase precursorGCratio: 2.47426037
A6621 GMDS_HUMANGMDSGDP-mannose 4,6 dehydrataseGMDSratio: 1.526833971
A9925 GPA33_HUMANGPA33Cell surface A33 antigen precursorGPA33ratio: 1.807499329
A3667 GPDM_HUMANGPD2Glycerol-3-phosphate dehydrogenase, mitochondrial precursorGPD2ratio: 1.251265904
A6643 GPX2_HUMANGPX2Glutathione peroxidase 2GPX2ratio: 1.405426661
A2010 GRP75_HUMANHSPA9, GRP75, HSPA9BStress-70 protein, mitochondrial precursorHSPA9ratio: 1.657765349
A0451 GRP78_HUMANHSPA5, GRP78Heat shock 70kDa protein 5HSPA5ratio: 0.635011534
A1952 GSTK1_HUMANGSTK1, HDCMD47PGlutathione S-transferase, mitochondrialGSTK1ratio: 4.582170327
A1961 GSTP1_HUMANGSTP1, FAEES3, GST3Glutathione S-transferase PGSTP1ratio: 5.039823373
A1741 HBA_HUMANHBA1, HBA2, HBZHemoglobin subunit alphaHBA1ratio: 0.584535599
A1742 HBB_HUMANHBB, beta-globinHemoglobin beta chainHBBratio: 0.416867832
A1841 HBE_HUMANHBE1, HBEHemoglobin epsilon chainHBG1ratio: 1.079756478
A524A HDGF_HUMANHDGF, HMG1L2Hepatoma-derived growth factorHDGFratio: 0.418753167
A021C HEMO_HUMANHPXHemopexin precursorHPXratio: 2.425236662
A1828 HLAG_HUMANHLA-G, HLA-6.0, HLAGHLA class I histocompatibility antigen, alpha chain G precursorHLA-Aratio: 0.294179529
A6733 HMCS2_HUMANHMGCS2Hydroxymethylglutaryl-CoA synthase, mitochondrial precursorHMGCS2ratio: 2.429037293
A0717 HNRPK_HUMANHNRNPK, HNRPKHeterogeneous nuclear ribonucleoprotein KHNRNPKratio: 2.124542038
A3792 HNRPM_HUMANHNRNPM, HNRPM, NAGR1Heterogeneous nuclear ribonucleoprotein MHNRNPMratio: 1.361033003
A0599 HNRPQ_HUMANSYNCRIP, HNRPQ, NSAP1Heterogeneous nuclear ribonucleoprotein QSYNCRIPratio: 1.941329996
A2531 HNRPR_HUMANHNRNPR, HNRPRHeterogeneous nuclear ribonucleoprotein RHNRNPRratio: 1.325931351
A0191 HS90A_HUMANHSP90AA1, HSP90A, HSPC1Heat shock protein HSP 90-alphaHSP90AA1ratio: 0.814175864
A2003 HS90B_HUMANHSP90AB1, HSP90B, HSPC2Heat shock protein 90kDa alpha (cytosolic), class B member 1HSP90AB1ratio: 0.393404206
A2007 HSP71_HUMANHSPA1A, HSPA1B, HSPA1Heat shock 70 kDa protein 1HSPA1Aratio: 0.57211415
A4856 HSPB1_HUMANHSPB1, HSP27, HSP28Heat shock protein beta-1HSPB1ratio: 0.271783133
A4347 HSPB6_HUMANHSPB6Heat-shock protein beta-6HSPB6ratio: 0.228070632
A4348 HSPB7_HUMANHSPB7, CVHSPHeat-shock protein, beta-7HSPB7ratio: 0.301967467
A540D HTR5A_HUMANHEATR5AHEAT repeat-containing protein 5AIGHMratio: 3.084982951
A3663 HXK1_HUMANHK1-tc, HK1-tb, HK1-taHexokinase 1HK1ratio: 1.401464343
A6760 HXK2_HUMANHK2Hexokinase, type IIHK2ratio: 1.888223012
A4350 HYOU1_HUMANHYOU1, GRP170, ORP150Hypoxia up-regulated protein 1 precursorHYOU1ratio: 0.883648535
A1591 IC1_HUMANSERPING1, C1IN, C1NHSerine/cysteine proteinase inhibitor clade G member 1SERPING1ratio: 1.906563997
A3661 IDHC_HUMANIDH1, PICDIsocitrate dehydrogenase [NADP] cytoplasmicIDH1ratio: 1.79546233
A3660 IDHP_HUMANIDH2, IDH, IDPIsocitrate dehydrogenase [NADP], mitochondrial precursorIDH2ratio: 1.444145361
A3206 IKIP_HUMANIKBIP, IKIP, IKIP2Inhibitor of nuclear factor kappa-B kinase-interacting proteinSLC25A3ratio: 1.784592032
A8420 ILEU_HUMANSERPINB1, ELANH2, MNEILeukocyte elastase inhibitorSERPINB1ratio: 2.755277395
A6789 IMDH2_HUMANIMPDH2, IMPD2Inosine-5'-monophosphate dehydrogenase 2IMPDH2ratio: 0.880304535
A3973 IMMT_HUMANIMMT, HMP, PIG4Mitochondrial inner membrane proteinIMMTratio: 0.337754796
A6804 IPYR_HUMANPPA1, IOPPP, PPInorganic pyrophosphatasePPA1ratio: 1.61471498
A0213 IQGA1_HUMANIQGAP1Ras GTPase-activating-like protein IQGAP1IQGAP1ratio: 1.418668668
A1694 ITA1_HUMANITGA1, PELOIntegrin alpha-1ITGA1ratio: 0.596561064
A0474 ITA5_HUMANITGA5, FNRAIntegrin alpha-5 precursorITGA5ratio: 0.413330068
A1528 ITA6_HUMANITGA6Integrin alpha-6GFPT1ratio: 1.872843027
A1693 ITA7_HUMANITGA7, UNQ406/PRO768Integrin alpha-7 precursorITGA7ratio: 0.639622212
A0099 ITB1_HUMANITGB1, FNRB, MDF2Integrin beta-1 precursorITGB1ratio: 0.48207444
A8431 ITIH1_HUMANITIH1, IGHEP1, PRO2769Inter-alpha (globulin) inhibitor H1ITIH1ratio: 3.043177366
A8432 ITIH2_HUMANITIH2, IGHEP2Inter-alpha-trypsin inhibitor heavy chain H2 precursorITIH2ratio: 2.143377026
A8434 ITIH4_HUMANITIH4, IHRP, ITIHL1Inter-alpha-trypsin inhibitor heavy chain H4 precursorITIH4ratio: 2.855226358
A9965 ITLN1_HUMANITLN1, INTL, ITLNIntelectin 1ITLN1ratio: 1.67171065
A615D K1755_HUMAN Hypothetical proteinTGM2ratio: 1.125197013
A3824 K1C10_HUMANKRT10, KPPKeratin, type I cytoskeletal 10KRT10ratio: 1.386190693
A3787 K1C19_HUMANKRT19, K19Keratin, type I cytoskeletal 19KRT19ratio: 1.367747664
A0338 K1C20_HUMANKRT20Keratin, type I cytoskeletal 20KRT20ratio: 1.878135681
A3829 K1C9_HUMANKRT9Keratin, type I cytoskeletal 9KRT9ratio: 1.697400649
A3849 K2C1_HUMANKRT1, KRTAKeratin, type II cytoskeletal 1KRT1ratio: 1.567209681
A3848 K2C7_HUMANKRT7, SCLKeratin, type II cytoskeletal 7KRT7ratio: 1.458770672
A3861 K2C78_HUMANKRT78, K5B, KB40Keratin, type II cytoskeletal 78KRT8ratio: 1.542004705
A1925 K6PL_HUMANPFKLPhosphofructokinase, liverPFKLratio: 2.766143322
A622D KANK2_HUMANKANK2, ANKRD25, MXRA3Ankyrin repeat domain-containing protein 25KANK2ratio: 0.409217338
A2286 KCD12_HUMANKCTD12, PFET1BTB/POZ domain-containing protein KCTD12KCTD12ratio: 1.936166644
A3693 KCRB_HUMANCKB, CKBBCreatine kinase B-typeCKBratio: 0.220081538
A2278 KCTD6_HUMANKCTD6Potassium channel tetramerisation domain containing 6PDHBratio: 1.925943692
A3531 KTN1_HUMANKTN1, CG1, PDIA6KinectinPDIA6ratio: 0.922393103
A3531 KTN1_HUMANKTN1, CG1, PDIA6KinectinKTN1ratio: 0.2635181
A1560 LAMA5_HUMANLAMA5Laminin subunit alpha-5LAMA5ratio: 1.029919167
A1508 LAMB1_HUMANLAMB1Laminin subunit beta-1LAMB1ratio: 0.432147364
A1517 LAMB2_HUMANLAMB2, LAMSLaminin beta-2 chain precursorLAMB2ratio: 0.821012139
A1518 LAMC1_HUMANLAMC1, LAMB2Laminin gamma-1 chain precursorLAMC1ratio: 0.468870441
A0370 LDHA_HUMANLDHA, PIG19L-lactate dehydrogenase A chainLDHAratio: 4.297101339
A651D LEG4_HUMANLGALS4Galectin-4LGALS4ratio: 2.490676006
A4004 LETM1_HUMANLETM1Leucine zipper-EF-hand containing transmembrane protein 1, mitochondrialLETM1ratio: 0.811894278
A4941 LG3BP_HUMANLGALS3BP, M2BPGalectin-3-binding protein precursorLGALS3BPratio: 1.875682672
A0430 LMNB1_HUMANLMNB1, LMN2, LMNBLamin B1LMNB1ratio: 0.426544706
A2492 LMNB2_HUMANLMNB2, LMN2Lamin B2LMNB2ratio: 0.482391944
A665D LMO7_HUMANLMO7, FBX20, FBXO20LIM domain only protein 7LMO7ratio: 0.535236011
A3999 LPPRC_HUMANLRPPRC, LRP130Leucine-rich PPR-motif containing proteinLRPPRCratio: 1.084818621
B9054 LRC38_HUMANLRRC38Leucine-rich repeat-containing protein 38EPRSratio: 0.886575639
A4951 LUM_HUMANLUM, LDC, SLRR2DLumican precursorLUMratio: 2.34296902
A6929 LYAG_HUMANGAALysosomal alpha-glucosidase precursorGAAratio: 1.349161069
A6992 MDHC_HUMANMDH1, MDHAMalate dehydrogenase, cytoplasmicMDH1ratio: 0.828734279
A3696 MDHM_HUMANMDH2Malate dehydrogenase, mitochondrial precursorMDH2ratio: 3.412494342
A1655 MMP9_HUMANMMP9, CLG4BMatrix metalloproteinase-9MMP9ratio: 0.744816243
B9897 MOT8_HUMANSLC16A2, MCT8, XPCTSolute carrier family 16, member 2PGK1ratio: 1.875520984
A3949 MTCH2_HUMANMTCH2, MIMP, HSPC032Mitochondrial carrier homolog 2MTCH2ratio: 2.320394317
A7084 MTNB_HUMANAPIP, CGI-29, MMRP19Methylthioribulose-1-phosphate dehydrataseAPIPratio: 1.45799772
A4986 MUC1_HUMANMUC1, PUMMucin-1MUC1ratio: 4.699945927
A4991 MUC18_HUMANMCAM, MUC18Cell surface glycoprotein MUC18 precursorMCAMratio: 0.536544303
A4992 MUC2_HUMANMUC2, mucin, MLPMucin 2 precursorMUC2ratio: 0.804942171
A2616 MUC5A_HUMANMUC5AC, MUC5, MUC 5ACMucin 5ACCCT4ratio: 2.352036675
A156C MVP_HUMANMVP, LRPMajor vault proteinMVPratio: 2.704491695
A2331 MYH11_HUMANMYH11, SMMHCMyosin heavy chain, smooth muscle isoformMYH11ratio: 0.128360267
A3962 MYH14_HUMANMYH14, FP17425Myosin-14MYH14ratio: 0.681481262
A3166 MYH9_HUMANMYH9Myosin heavy chain 9, non-muscleMYH9ratio: 0.521420151
A4049 MYL6_HUMANMYL6, MLC3nm, LC17AMyosin light polypeptide 6MYL6ratio: 0.093891914
A166C MYL9_HUMANMYL9, MLC2, MRLC1Myosin regulatory light polypeptide 9MYL9ratio: 0.173371901
A7110 NAMPT_HUMANNAMPT, NAMPTL, PBEFNicotinamide phosphoribosyltransferaseNAMPTratio: 1.590668281
A7119 NB5R1_HUMANCYB5R1, NQO3A2, UNQ3049/PRO9865NADH-cytochrome b5 reductase 1CYB5R1ratio: 2.077123364
A3561 NDUS1_HUMANNDUFS1, PRO1304NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursorNDUFS1ratio: 1.461812298
A3564 NDUS3_HUMANNDUFS3NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialNDUFS3ratio: 2.623645743
A224C NGAL_HUMANLCN2, HNL, NGALNeutrophil gelatinase-associated lipocalin precursorLCN2ratio: 1.293806712
A1585 NID1_HUMANNID1, NIDNidogen-1NID1ratio: 0.715332428
A5008 NID2_HUMANNID2Nidogen-2NID2ratio: 0.924387038
A2536 NUCL_HUMANNCLNucleolinNCLratio: 0.305807133
A3664 ODO1_HUMANOGDH2-oxoglutarate dehydrogenase E1 component, mitochondrial precursorOGDHratio: 1.778496663
A5018 OLFM4_HUMANOLFM4, GW112, UNQ362/PRO698Olfactomedin-4OLFM4ratio: 3.671081782
A7262 P5CS_HUMANALDH18A1, GSAS, P5CSDelta 1-pyrroline-5-carboxylate synthetaseALDH18A1ratio: 0.771264851
A1271 PALLD_HUMANPALLD, CGI-151, MYNPalladinPALLDratio: 0.397070706
A1312 PARP1_HUMANPARP1, ADPRT, PPOLPoly [ADP]-ribose polymerase-1PARP1ratio: 0.456028631
A838A PDCD4_HUMANPDCD4, H731Programmed cell death 4PDCD4ratio: 1.079285781
A1816 PDIA3_HUMANPDIA3, ERP57, ERP60Protein disulfide isomerase A3 precursorPDIA3ratio: 1.121249676
A7340 PDIA4_HUMANPDIA4, ERP70, ERP72Protein disulfide isomerase A4 precursorPDIA4ratio: 0.476170272
A9740 PDLI7_HUMANPDLIM7, ENIGMAEnigma proteinPDLIM7ratio: 0.374466498
A8448 PEDF_HUMANSERPINF1, PEDF, PIG35Pigment epithelium-derived factor precursorSERPINF1ratio: 2.120302042
A7359 PERE_HUMANEPX, EPER, EPOEosinophil peroxidase precursorEPXratio: 0.932623446
A0459 PERI_HUMANPRPH, NEF4, PRPH1PeripherinPRPHratio: 0.81814458
A7361 PERM_HUMANMPOMyeloperoxidase precursorMPOratio: 0.589557608
A1555 PGBM_HUMANHSPG2Basement membrane-specific heparan sulfate proteoglycan core proteinHSPG2ratio: 0.66727825
BC313 PI5PA_HUMANINPP5J, PIB5PA, PIPPPhosphatidylinositol 4,5-bisphosphate 5-phosphatase ASMTNratio: 0.227242828
A1941 PLEC_HUMANPLEC1, PLECPlectinPLECratio: 0.810472945
A5085 PLSI_HUMANPLS1Plastin 1, I isoformPLS1ratio: 1.473136028
A5086 PLSL_HUMANLCP1, PLS2Plastin-2LCP1ratio: 1.380379001
A7447 PNCB_HUMANNAPRT1, FHIP, PP3856Nicotinate phosphoribosyltransferase-like proteinNAPRT1ratio: 3.263639013
A5090 POSTN_HUMANPOSTN, OSF2, OSF-2Periostin, osteoblast specific factorPOSTNratio: 4.798830986
A4370 PPIB_HUMANPPIB, CYPBPeptidyl-prolyl cis-trans isomerase B precursorPPIBratio: 1.294054349
A5096 PRELP_HUMANPRELP, SLRR2A, MST161Prolargin precursorPRELPratio: 2.125428319
A1284 PRKDC_HUMANPRKDC, HYRC, HYRC1DNA-dependent protein kinase catalytic subunitPRKDCratio: 0.632092834
A9534 PRP8_HUMANPRPF8, PRPC8, HPRP8Pre-mRNA-processing-splicing factor 8PRPF8ratio: 0.722933928
A7518 PSA1_HUMANPSMA1, HC2, NUProteasome subunit alpha type 1PSMA1ratio: 1.878986001
A887A PTRF_HUMANPTRF, FKSG13Polymerase I and transcript release factorPTRFratio: 0.23343197
A7558 PUR9_HUMANATIC, PURHBifunctional purine biosynthesis protein PURHATICratio: 1.734521707
A3588 PYGB_HUMANPYGBGlycogen phosphorylase, brain formPYGBratio: 0.541862835
A3676 QCR1_HUMANUQCRC1Ubiquinol-cytochrome C reductase complex core protein I, mitochondrial precursorUQCRC1ratio: 2.40825367
A3677 QCR2_HUMANUQCRC2Cytochrome B-C1 complex subunit 2, mitochondrialUQCRC2ratio: 2.181911667
A0152 RAN_HUMANRAN, ARA24, TC4GTP-binding nuclear protein RANRANratio: 5.159927368
A1136 ROA2_HUMANHNRNPA2B1, HNRPA2B1Heterogeneous nuclear ribonucleoproteins A2/B1HNRNPA2B1ratio: 2.028327664
A3639 RPN1_HUMANRPN1Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 67 kDa subunit precursorRPN1ratio: 0.79653579
A369C RRBP1_HUMANRRBP1Ribosome-binding protein 1RRBP1ratio: 0.137202268
A375C S12A2_HUMANSLC12A2, NKCC1Solute carrier family 12 member 2SLC12A2ratio: 1.667921702
A1597 SAMP_HUMANAPCS, PTX2Serum amyloid P-component precursorAPCSratio: 2.126528025
A463C SBP1_HUMANSELENBP1, SBPSelenium-binding protein 1SELENBP1ratio: 0.569355835
A3770 SCMC1_HUMANSLC25A24, APC1, MCSC1Solute carrier family 25 member 24SLC25A24ratio: 1.630505045
A495C SDPR_HUMANSDPRSerum deprivation response proteinSDPRratio: 0.364369273
BE726 SEBOX_HUMANSEBOX, OG9XHomeobox protein SEBOXVTNratio: 2.191376964
A1014 SFPQ_HUMANSFPQ, PSFSplicing factor, proline-and glutamine-richSFPQratio: 0.982333422
A313E SH3L1_HUMANSH3BGRLSH3 domain-binding glutamic acid-rich-like proteinSH3BGRLratio: 0.57651033
A3788 SND1_HUMANSND1, TDRD11Staphylococcal nuclease domain containing protein 1SND1ratio: 2.125684619
A9060 SORCN_HUMANSRISorcinSRIratio: 0.93473659
A8502 SPB5_HUMANSERPINB5, PI5Maspin precursorSERPINB5ratio: 3.902419965
A0010 SPTB2_HUMANSPTBN1, SPTB2, RPL23AP13Spectrin beta chain, brain 1SPTBN1ratio: 0.358693908
A5151 SPTN1_HUMANSPTAN1, SPTA2, NEASSpectrin alpha chain, brainSPTAN1ratio: 0.344124178
A7863 SQRD_HUMANSQRDL, CGI-44, PRO1975Sulfide:quinone oxidoreductase, mitochondrial precursorSQRDLratio: 1.759874662
A0100 SRBS1_HUMANSORBS1, CAP, SH3P12Sorbin and SH3 domain containing 1SORBS1ratio: 0.228020499
A2598 SRRM2_HUMANSRRM2, SRL300, SRM300Serine/arginine repeptitive matrix protein 2SRRM2ratio: 0.554386497
A0719 STAT1_HUMANSTAT1Signal transducer and activator of transcription 1-alpha/betaSTAT1ratio: 0.845216672
A0492 STIP1_HUMANSTIP1Stress-induced-phosphoprotein 1STIP1ratio: 0.384963294
A7900 SUCB2_HUMANSUCLG2Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial precursorSUCLG2ratio: 0.846661309
A7912 SYDC_HUMANDARS, PIG40Aspartyl-tRNA synthetaseDARSratio: 1.553411682
A7915 SYEP_HUMANEPRS, GLNS, PARSBifunctional aminoacyl-tRNA synthetaseQARSratio: 1.452284654
A7922 SYIC_HUMANIARS, PRO0785Isoleucyl-tRNA synthetase, cytoplasmicIARSratio: 0.945015192
A5169 SYNEM_HUMANSYNM, DMN, SYNSyneminSYNMratio: 0.165474003
A5170 SYNP2_HUMANSYNPO2, MYOPODINSynaptopodin 2SYNPO2ratio: 0.249681368
A7933 SYSC_HUMANSARS, SERSSeryl-tRNA synthetase, cytoplasmicSARSratio: 1.566991012
A7941 SYWC_HUMANWARS, IFI53, WRSTryptophanyl-tRNA synthetase, cytoplasmicWARSratio: 0.970210115
A5174 TAGL_HUMANTAGLN, SM22, WS3-10TransgelinTAGLNratio: 0.827005208
A371E TAGL2_HUMANTAGLN2, CDABP0035Transgelin 2TAGLN2ratio: 1.960873008
A3541 TCPA_HUMANTCP1, CCT1, CCTAT-complex protein 1, alpha subunitTCP1ratio: 2.326314648
A3540 TCPB_HUMANCCT2, 99D8.1, CCTBT-complex protein 1, beta subunitCCT2ratio: 1.819552024
A3543 TCPE_HUMANCCT5, CCTE, PNAS-102T-complex protein 1, epsilon subunitCCT5ratio: 1.538857341
A3544 TCPG_HUMANCCT3, CCTG, TRIC5T-complex protein 1, gamma subunitCCT3ratio: 2.132749677
A3539 TCPH_HUMANCCT7, CCTH, NIP7-1T-complex protein 1, eta subunitCCT7ratio: 2.149611712
A3542 TCPQ_HUMANCCT8, CCTQT-complex protein 1, theta subunitCCT8ratio: 2.089188973
A1525 TENA_HUMANTNC, HXBTenascin precursorTNCratio: 0.354445368
A1301 TGFI1_HUMANTGFB1I1, ARA55, Hic-5Transforming growth factor beta 1 induced transcript 1TGFB1I1ratio: 0.522800028
A9106 THIO_HUMANTXN delta 3, TXN, TRDXThioredoxinTXNratio: 2.09047401
A1469 THRB_HUMANF2Prothrombin precursorF2ratio: 2.125390688
A0097 TLN1_HUMANTLN1, TLNTalin 1TLN1ratio: 0.387400637
A127B TR150_HUMANTHRAP3, TRAP150Thyroid hormone receptor-associated protein 3THRAP3ratio: 0.233477741
A1712 TRFL_HUMANLTF, LF, GIG12Lactotransferrin precursorLTFratio: 1.515658021
A8080 TYPH_HUMANTYMP, ECGF1Thymidine phosphorylase precursorTYMPratio: 1.470134656
A2150 U520_HUMANSNRNP200, ASCC3L1, HELIC2U5 small nuclear ribonucleoprotein 200 kDa helicaseSNRNP200ratio: 0.725598792
A8092 UBA1_HUMANUBA1, UBE1, A1S9TUbiquitin-activating enzyme E1UBA1ratio: 2.392112335
A0425 VDAC1_HUMANVDAC1, VDAC, VDAC4Voltage-dependent anion-selective channel protein 1VDAC1ratio: 2.825493415
A5242 VILI_HUMANVIL1, VILVillin 1VIL1ratio: 1.537437359
A0850 VIME_HUMANVIMVimentinVIMratio: 4.107764721
A0098 VINC_HUMANVCLVinculinVCLratio: 0.341409127
A3909 VPS35_HUMANVPS35, MEM3Vacuolar protein sorting-associated protein 35VPS35ratio: 1.266137918
A9151 VWA1_HUMANVWA1, WARPVon Willebrand factor A domain-containing protein 1VWA1ratio: 0.746156732
A1521 VWF_HUMANVWF, F8VWFVon Willebrand factor precursorVWFratio: 0.907753249
A0777 XRCC5_HUMANXRCC5, G22P2, KARP-1X-ray repair cross-complementing protein 5XRCC5ratio: 1.287003676
A0716 XRCC6_HUMANXRCC6, G22P1X-ray repair cross-complementing protein 6XRCC6ratio: 1.379572988
A195A ZA2G_HUMANAZGP1, ZAG, ZNGP1Zinc-alpha-2-glycoprotein precursorAZGP1ratio: 1.87828803
A0429 ACON_HUMANACO2Aconitate hydratase, mitochondrial precursorACO2ratio: 1.461976329
A0340 AT1A1_HUMANATP1A1Sodium/potassium-transporting ATPase alpha-1 chain precursorATP1A1ratio: 2.099093
BJ443 BL1S5_HUMANBLOC1S5, MUTED, BLOC1S5-TXNDC5Muted protein homologTXNDC5ratio: 0.992205461
A4629 CALD1_HUMANCALD1, CAD, CDMCaldesmonCALD1ratio: 0.183746765
A541A HMGA2_HUMANHMGIC, HMGA2, HMGA2DHigh mobility group protein HMGI-CHMGA2ratio: 0.22732336
A1631 HPT_HUMANHPHaptoglobin precursorHPratio: 3.174881697
A1577 K1C18_HUMANKRT18, CYK18, PIG46Keratin, type I cytoskeletal 18KRT18ratio: 2.0251743
A0778 MAP4_HUMANMAP4Microtubule-associated protein 4MAP4ratio: 0.428359042
A9994 MIME_HUMANOGN, OIF, SLRR3AMimecan precursorOGNratio: 1.090445717
A1004 MYPT1_HUMANPPP1R12A, MBS, MYPT1Protein phosphatase 1 regulatory (inhibitor) subunit 12APPP1R12Aratio: 0.550502062
A757D NUCKS_HUMANNUCKS1, NUCKS, JC7Nuclear ubiquitous casein and cyclin-dependent kinases substrateNUCKS1ratio: 0.298156972
A1733 PDIA1_HUMANP4HB, ERBA2L, PDIProtein disulfide isomerase precursorP4HBratio: 1.56172204
A0325 TENS1_HUMANTNS1, TNSTensin-1TNS1ratio: 0.452398638
A643C TRFE_HUMANTF, PRO1400Serotransferrin precursorTFratio: 2.217214306
A681C VIGLN_HUMANHDLBP, HBP, VGLVigilinHDLBPratio: 0.889922937

Compile date 10-20-2017© .