MoCadb-logoMoCadb - Study ID Exp26175278a

PubMed ID26175278
AuthorsYin X(1), Zhang Y(2), Guo S(3), Jin H(2), Wang W(3), Yang P(1).
TitleLarge scale systematic proteomic quantification from non-metastatic to metastatic colorectal cancer.
JournalSci Rep. 2015 Jul 15;5:12120.
AbstractA systematic proteomic quantification of formalin-fixed, paraffin-embedded (FFPE) colorectal cancer tissues from stage I to stage IIIC was performed in large scale. 1017 proteins were identified with 338 proteins in quantitative changes by label free method, while 341 proteins were quantified with significant expression changes among 6294 proteins by iTRAQ method. We found that proteins related to migration expression increased and those for binding and adherent decreased during the colorectal cancer development according to the gene ontology (GO) annotation and ingenuity pathway analysis (IPA). The integrin alpha 5 (ITA5) in integrin family was focused, which was consistent with the metastasis related pathway. The expression level of ITA5 decreased in metastasis tissues and the result has been further verified by Western blotting. Another two cell migration related proteins vitronectin (VTN) and actin-related protein (ARP3) were also proved to be up-regulated by both mass spectrometry (MS) based quantification results and Western blotting. Up to now, our result shows one of the largest dataset in colorectal cancer proteomics research. Our strategy reveals a disease driven omics-pattern for the metastasis colorectal cancer.

Sample characteristics

SpeciesTissue / SourceDiseaseNDetection methodSample
Homo sapienscolon_rectumCRC (Stage II)16LC-MS/MSDem26175278a, Dem26175278b

Sample description and preparation

N (case)7
N (control)9
Disease (case)CRC (Stage II)
Disease (control)Stage I
Preparation specific methodiTRAQ-labelling
Digestin-solution digestion, Trypsin

Sample analysis

Software thresholdP<0.05, fold change>1.5

Molecule list

Molecule IDextExternal IDGeneNameSource accRegulation (case/control)Scores
A0280 1433E_HUMANYWHAE14-3-3 protein epsilonYWHAEratio: 2.318677703
A0361 1433Z_HUMANYWHAZ14-3-3 protein zeta/deltaYWHAZratio: 1.550065001
A5622 6PGD_HUMANPGD, PGDH6-phosphogluconate dehydrogenase, decarboxylatingPGDratio: 1.370260993
A5625 A1AG1_HUMANORM1, AGP1, ORM2Alpha-1-acid glycoprotein 1 precursorORM1ratio: 2.679099639
A8369 A1AT_HUMANA1A, SERPINA1, AATAlpha-1-antitrypsin precursorSERPINA1ratio: 0.602174391
A1177 A2MG_HUMANA2M, CPAMD5, FWP007Alpha-2-macroglobulin precursorA2Mratio: 0.1805664
A8381 AACT_HUMANSERPINA3, AACT, GIG24Alpha-1-antichymotrypsin precursorSERPINA3ratio: 1.830804666
A5657 ACADV_HUMANACADVL, VLCADAcyl-CoA dehydrogenase, very-long-chain specific, mitochondrial precursorACADVLratio: 1.692152302
A5670 ACOC_HUMANACO1, IRP1, IREB1Iron-responsive element binding protein 1ACO1ratio: 1.17364033
A5696 ACSL5_HUMANACSL5, ACS5, FACL5Long-chain-fatty-acid--CoA ligase 5ACSL5ratio: 1.671095014
A2341 ACTN1_HUMANACTN1Alpha-actinin 1ACTN1ratio: 0.553836147
A2344 ACTN4_HUMANACTN4Alpha-actinin 4ACTN4ratio: 0.342522631
A204A AEBP1_HUMANAEBP1, ACLPAdipocyte enhancer-binding protein 1AEBP1ratio: 1.082057973
A0849 AHNK_HUMANAHNAK, PM227Neuroblast differentiation associated protein AHNAKAHNAKratio: 0.169673771
A3781 AIFM1_HUMANPDCD8, AIFM1, AIFProgrammed cell death protein 8, mitochondrial precursorAIFM1ratio: 1.432518681
A5750 AK1A1_HUMANAKR1A1, ALDR1, ALRAlcohol dehydrogenase [NADP]AKR1A1ratio: 1.03194956
A5751 AK1BA_HUMANAKR1B10, AKR1B11Aldo-keto reductase family 1 member B10AKR1B10ratio: 1.38542521
A0802 AKA12_HUMANAKAP12, AKAP250A-kinase anchor protein 12AKAP12ratio: 0.759945571
B0534 AKTS1_HUMANAKT1S1, PRAS40Proline-rich AKT1 substrate 1IL4I1ratio: 0.921927015
A3585 AL1A1_HUMANALDH1A1, ALDC, ALDH1Aldehyde dehydrogenase 1A1ALDH1A1ratio: 1.930141012
A3599 AL1B1_HUMANALDH1B1, ALDH5, ALDHXAldehyde dehydrogenase X, mitochondrialALDH1B1ratio: 1.300301631
A5766 AL4A1_HUMANALDH4A1, ALDH4, P5CDHDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursorALDH4A1ratio: 1.946872354
A1581 ALBU_HUMANALB, GIG20, GIG42Serum albumin precursorALBratio: 0.688601101
A3598 ALDH2_HUMANALDH2, ALDMAldehyde dehydrogenase, mitochondrial precursorALDH2ratio: 3.23566397
A5788 AMACR_HUMANAMACRAlpha-methylacyl-CoA racemaseAMACRratio: 3.928287029
A5797 AMPL_HUMANLAP3, LAPEP, PEPSCytosol aminopeptidaseLAP3ratio: 0.52639241
A8384 ANT3_HUMANAT3, SERPINC1, PRO0309Antithrombin-III precursorSERPINC1ratio: 1.568425337
A0647 ANXA1_HUMANANXA1, ANX1, LPC1Annexin A1ANXA1ratio: 0.578718951
A0537 ANXA2_HUMANANXA2, ANX2, ANX2L4Annexin A2ANXA2ratio: 0.569661875
A8385 ANXA3_HUMANANXA3, ANX3Annexin A3ANXA3ratio: 0.866031249
A4575 ANXA4_HUMANANXA4, PIG28, ANX4Annexin A4ANXA4ratio: 0.902852476
A4576 ANXA5_HUMANANXA5, ANX5, ENX2Annexin A5ANXA5ratio: 0.565356056
A0029 ANXA6_HUMANANXA6, ANX6Annexin A6ANXA6ratio: 0.195315133
A5813 AOC3_HUMANAOC3, VAP1Membrane copper amine oxidaseAOC3ratio: 0.287605594
A3672 AOFA_HUMANMAOAAmine oxidase [flavin-containing] AMAOAratio: 1.402131716
B0829 APC15_HUMANANAPC15, HSPC020Uncharacterized protein C11ORF51NUMA1ratio: 0.700334976
A5815 APEX1_HUMANAPEX1, APE, APEXDNA-(apurinic or apyrimidinic site) lyaseAPEX1ratio: 2.46797657
A1552 APOA1_HUMANAPOA1, A175PApolipoprotein A-I precursorAPOA1ratio: 1.413494349
A1714 APOB_HUMANAPOBApolipoprotein B-100 precursorAPOBratio: 0.796883027
A1176 APOE_HUMANAPOEApolipoprotein E precursorAPOEratio: 1.590222359
A5817 APT_HUMANAPRTAdenine phosphoribosyltransferaseAPRTratio: 2.597658674
A0455 ARF1_HUMANARF1ADP-ribosylation factor 1ARF1ratio: 6.548368454
A8672 ARP21_HUMANARPP21, ARPP-21, TARPPcAMP-regulated phosphoprotein 21PDCD6IPratio: 0.474525849
A0233 ARPC2_HUMANARPC2, ARC34, PRO2446ARP2/3 complex 34 kDa subunitARPC2ratio: 0.827717364
A0231 ARPC4_HUMANARPC4, ARC20, ARPC4-TTLL3Actin-related protein 2/3 complex subunit 4ARPC4ratio: 1.251083334
A5828 ARY1_HUMANNAT1, AAC1Arylamine N-acetyltransferase 1ASAH1ratio: 0.731615007
A5840 ASPH_HUMANASPHJunctinASPHratio: 1.074407101
A5842 ASSY_HUMANASS1, ASSArgininosuccinate synthaseASS1ratio: 0.744597932
A0344 AT1B1_HUMANATP1B1, ATP1BSodium/potassium-transporting ATPase beta-1 chainATP1B1ratio: 0.608359555
A0387 ATP5H_HUMANATP5H, My032ATP synthase D chain, mitochondrialATP5Hratio: 1.532545646
A0377 ATPA_HUMANATP5A1, ATP5A, ATP5AL2ATP synthase alpha chain, mitochondrial precursorATP5A1ratio: 1.258477946
A0378 ATPB_HUMANATP5B, ATPMB, ATPSBATP synthase beta chain, mitochondrial precursorATP5Bratio: 1.26731503
A4618 CAD17_HUMANCDH17Cadherin-17CDH17ratio: 0.334807401
A5964 CAH2_HUMANCA2Carbonic anhydrase 2CA2ratio: 0.565306047
A1609 CALR_HUMANCALR, CRTCCalreticulin precursorCALRratio: 0.690565169
A0452 CALX_HUMANCANXCalnexin precursorCANXratio: 0.725136578
A0317 CAN1_HUMANCAPN1, CANPL1, PIG30Calpain 1, large [catalytic] subunitCAPN1ratio: 1.929957946
A267A CAND1_HUMANCAND1, TIP120, TIP120ACullin-associated NEDD8-dissociated protein 1CAND1ratio: 0.943609893
A5981 CATA_HUMANCATCatalaseCATratio: 0.415655936
A5984 CATD_HUMANCTSD, CPSDCathepsin D precursorCTSDratio: 0.437461873
A5995 CBPA3_HUMANCPA3Mast cell carboxypeptidase ACPA3ratio: 0.856065432
A1663 CCR5_HUMANCCR5, CCR-5, CMKBR5C-C chemokine receptor type 5EEF1A1ratio: 1.523183346
A6042 CERU_HUMANCPCeruloplasmin precursorCPratio: 0.643254181
A1602 CFAB_HUMANCFB, BF, BFDComplement factor B precursorCFBratio: 1.333391667
A3550 CH60_HUMANHSPD1, HSP6060 kDa heat shock protein, mitochondrial precursorHSPD1ratio: 3.50243632
B2884 CIB4_HUMANCIB4Calcium and integrin-binding family member 4VDAC2ratio: 1.045699437
A3688 CISY_HUMANCSCitrate synthase, mitochondrial precursorCSratio: 3.08790032
A3211 CKAP4_HUMANCKAP4, P63P63 proteinCKAP4ratio: 0.858724475
A878B CLCA1_HUMANCLCA1, CACC1, HCLCA1Chloride channel, calcium activated, family member 1 precursorCLCA1ratio: 2.434609969
A0119 CLH1_HUMANCLTC, CLH17, CLTCL2Clathrin heavy chain 1CLTCratio: 0.835477372
A9274 CLM1_HUMANCD300LF, UNQ3105, PIGRCMRF35-like molecule 1PIGRratio: 0.833941202
A1276 CLUS_HUMANCLU, APOJ, CLIClusterin precursorCLUratio: 1.984541019
A6078 CMBL_HUMANCMBLCarboxymethylenebutenolidase homologCMBLratio: 2.140529712
A3747 CMC2_HUMANSLC25A13, ARALAR2Calcium-binding mitochondrial carrier protein Aralar2SLC25A13ratio: 1.693878015
A9841 CMGA_HUMANCHGAChromogranin A precursorCHGAratio: 0.794271827
B3213 CNG1O_HUMAN Putative anti-CNG alpha 1 cation channel translation productSORBS2ratio: 0.441145698
A4685 CNN1_HUMANCNN1Calponin H1, smooth muscleCNN1ratio: 0.592568596
A1598 CO3_HUMANC3, CPAMD1Complement C3 precursorC3ratio: 0.431954831
A1410 CO6A1_HUMANCOL6A1Collagen alpha 1(VI) chain precursorCOL6A1ratio: 0.207215702
A1422 CO6A2_HUMANCOL6A2Collagen alpha 2(VI) chain precursorCOL6A2ratio: 0.271064073
A1423 CO6A3_HUMANCOL6A3Collagen alpha 3(VI) chain precursorCOL6A3ratio: 0.926232497
A1628 CO9_HUMANC9Complement component C9 precursorC9ratio: 2.058554967
A2407 COCA1_HUMANCOL12A1, COL12A1LCollagen alpha 1(XII) chain precursorCOL12A1ratio: 0.523680508
A4709 COEA1_HUMANCOL14A1, UNDCollagen alpha-1(XIV) chain precursorCOL14A1ratio: 0.293433602
A4710 COF2_HUMANCFL2Cofilin 2CFL2ratio: 0.451961626
A2102 COPA_HUMANCOPACoatomer alpha subunitCOPAratio: 0.846356094
A897B COPG1_HUMANCOPG, COPG1Coatomer gamma subunitCOPG1ratio: 1.071158012
A6203 CPT1A_HUMANCPT1A, CPT1Carnitine O-palmitoyltransferase I, mitochondrial liver isoformCPT1Aratio: 1.602107008
A205D CRBG3_HUMANCRYBG3Beta/gamma crystallin domain-containing protein 3MYLKratio: 0.420725067
A3555 CSPG2_HUMANVCAN, CSPG2Versican core protein precursorVCANratio: 2.279860337
A0535 DESM_HUMANDES, CSM-7, CSM-6DesminDESratio: 0.893055241
A6308 DHB4_HUMANHSD17B4, EDH17B4Peroxisomal multifunctional enzyme type 2HSD17B4ratio: 1.387759646
A3680 DHE3_HUMANGLUD1, GLUDGlutamate dehydrogenase 1, mitochondrial precursorGLUD1ratio: 1.017388741
A6356 DPEP1_HUMANDPEP1, MDP, RDPMicrosomal dipeptidase precursorDPEP1ratio: 3.094278018
B4617 DRC1_HUMANDRC1, CCDC164UPF0407 protein C2ORF39HADHBratio: 1.94499131
A0133 DYHC1_HUMANDYNC1H1, Dnchc1, DHC1Dynein heavy chain, cytosolicDYNC1H1ratio: 0.812913179
B4764 E400N_HUMANEP400NLEP400 N-terminal-like proteinSHMT2ratio: 3.965105057
A3683 ECHA_HUMANHADHA, HADHTrifunctional enzyme alpha subunit, mitochondrial precursorHADHAratio: 1.355624318
A1968 EF1G_HUMANEEF1G, EF1G, PRO1608Elongation factor 1-gammaEEF1Gratio: 3.08007431
A3804 EF2_HUMANEEF2, EF2Elongation factor 2EEF2ratio: 0.878104448
A370A EFTU_HUMANTUFMElongation factor Tu, mitochondrial precursorTUFMratio: 1.975557685
A1390 EHD4_HUMANEHD4, HCA10, HCA11EH-domain containing protein 4EHD4ratio: 1.05053103
A0243 EIF3A_HUMANEIF3A, EIF3S10Eukaryotic translation initiation factor 3 subunit 10EIF3Aratio: 1.522324999
A376A EIF3B_HUMANEIF3B, EIF3S9Eukaryotic translation initiation factor 3 subunit 9EIF3Bratio: 1.595098019
A385A EIF3L_HUMANEIF3L, EIF3EIP, EIF3S6IPEukaryotic translation initiation factor 3 subunit 6 interacting proteinEIF3Lratio: 1.829085986
A4784 EMIL1_HUMANEMILIN1, EMIEMILIN 1 precursorEMILIN1ratio: 0.64283065
A0816 ENAH_HUMANENAH, MENAEnabled protein homologENAHratio: 0.990393818
A0816 ENAH_HUMANENAH, MENAEnabled protein homologENAHratio: 0.990393818
A2004 ENPL_HUMANHSP90B1, GRP94, TRA1Endoplasmin precursorHSP90B1ratio: 0.598615835
A4316 ENPLL_HUMANHSP90B2P, GRP94B, GRP94P1Heat shock protein 94BTRAP1ratio: 2.215466023
A6436 ERAP1_HUMANERAP1, APPILS, ARTS1Endoplasmic reticulum aminopeptidase 1ERAP1ratio: 1.408059001
A6449 ERO1A_HUMANERO1L, UNQ434/PRO865, ERO1-LERO1-like protein alphaERO1Lratio: 1.404402971
A6455 EST1_HUMANCES1, CES1A1a, CES1A1Carboxylesterase 1A1CES1ratio: 0.446265628
A428B ESYT1_HUMANESYT1, FAM62A, MBC2Extended syntaptotagmin-1ESYT1ratio: 1.125462194
A0326 EZRI_HUMANVIL2, EZREzrinEZRratio: 1.229722738
A6477 F16P1_HUMANFBP1, FBPFructose-1,6-bisphosphatase 1FBP1ratio: 0.418605795
A979B FABPL_HUMANFABP1, FABPLFatty acid-binding protein, liverFABP1ratio: 0.653509796
A4117 FANCC_HUMANFANCC, FAC, FACCFanconi anemia group C proteinPGM5ratio: 0.549412549
A4120 FANCG_HUMANFANCG, XRCC9Fanconi anemia group G proteinVCPratio: 0.727281054
A3584 FAS_HUMANFASN, FASFatty acid synthaseFASNratio: 1.650450985
A9713 FCGBP_HUMANFCGBPIgG Fc binding proteinFCGBPratio: 0.6876553
A1467 FIBA_HUMANFGAFibrinogen alpha/alpha-E chain precursorFGAratio: 1.463129004
A1493 FIBB_HUMANFGBFibrinogen beta chain precursorFGBratio: 2.372571309
A1494 FIBG_HUMANFGG, PRO2061Fibrinogen gamma chain precursorFGGratio: 1.304862499
A1466 FINC_HUMANFN1, FNFibronectinFN1ratio: 0.952529232
A0204 FLNA_HUMANFLNA, FLN, FLN1Filamin AFLNAratio: 0.190713868
A4814 FLNB_HUMANFLNB, FLN3, TAPFilamin-BFLNBratio: 0.757643739
A4815 FLNC_HUMANFLNC, ABPL, FLN2Filamin CFLNCratio: 0.268372864
A0224 FSCN1_HUMANFSCN1, FAN1, HSNFascin 1FSCN1ratio: 1.262434006
A6548 G6PD_HUMANG6PDGlucose-6-phosphate 1-dehydrogenaseG6PDratio: 0.997281651
A6556 GALE_HUMANGALEUDP-glucose 4-epimeraseGALEratio: 2.499184966
A1215 GANAB_HUMANGANAB, G2ANNeutral alpha-glucosidase ABGANABratio: 3.625667413
A0124 GBLP_HUMANGNB2L1, HLC7, PIG21Guanine nucleotide-binding protein beta subunit-like protein 12.3GNB2L1ratio: 2.378740629
A483D GBP1_HUMANGBP1Interferon-induced guanylate-binding protein 1GBP1ratio: 0.569078942
A0419 GELS_HUMANGSNGelsolin precursor, plasmaGSNratio: 0.290672898
A1082 GGT5_HUMANGGT5, GGTLA1Gamma-glutamyltransferase 5 precursorGGT5ratio: 1.422262073
A6600 GLCM_HUMANGBA, GC, GLUCGlucosylceramidase precursorGCratio: 0.980610688
A6621 GMDS_HUMANGMDSGDP-mannose 4,6 dehydrataseGMDSratio: 1.354841987
A9925 GPA33_HUMANGPA33Cell surface A33 antigen precursorGPA33ratio: 2.334262291
A3667 GPDM_HUMANGPD2Glycerol-3-phosphate dehydrogenase, mitochondrial precursorGPD2ratio: 1.452537974
A6643 GPX2_HUMANGPX2Glutathione peroxidase 2GPX2ratio: 2.28179725
A2010 GRP75_HUMANHSPA9, GRP75, HSPA9BStress-70 protein, mitochondrial precursorHSPA9ratio: 1.914642652
A0451 GRP78_HUMANHSPA5, GRP78Heat shock 70kDa protein 5HSPA5ratio: 0.375292569
A1952 GSTK1_HUMANGSTK1, HDCMD47PGlutathione S-transferase, mitochondrialGSTK1ratio: 1.711770018
A1961 GSTP1_HUMANGSTP1, FAEES3, GST3Glutathione S-transferase PGSTP1ratio: 5.386962255
A1741 HBA_HUMANHBA1, HBA2, HBZHemoglobin subunit alphaHBA1ratio: 0.375278592
A1742 HBB_HUMANHBB, beta-globinHemoglobin beta chainHBBratio: 0.084410337
A1841 HBE_HUMANHBE1, HBEHemoglobin epsilon chainHBG1ratio: 1.669622978
A524A HDGF_HUMANHDGF, HMG1L2Hepatoma-derived growth factorHDGFratio: 0.810229977
A021C HEMO_HUMANHPXHemopexin precursorHPXratio: 0.699150582
A1828 HLAG_HUMANHLA-G, HLA-6.0, HLAGHLA class I histocompatibility antigen, alpha chain G precursorHLA-Aratio: 0.754845103
A6733 HMCS2_HUMANHMGCS2Hydroxymethylglutaryl-CoA synthase, mitochondrial precursorHMGCS2ratio: 2.401212692
A0717 HNRPK_HUMANHNRNPK, HNRPKHeterogeneous nuclear ribonucleoprotein KHNRNPKratio: 2.600785414
A3792 HNRPM_HUMANHNRNPM, HNRPM, NAGR1Heterogeneous nuclear ribonucleoprotein MHNRNPMratio: 1.713592291
A0599 HNRPQ_HUMANSYNCRIP, HNRPQ, NSAP1Heterogeneous nuclear ribonucleoprotein QSYNCRIPratio: 2.687659025
A2531 HNRPR_HUMANHNRNPR, HNRPRHeterogeneous nuclear ribonucleoprotein RHNRNPRratio: 1.675752998
A0191 HS90A_HUMANHSP90AA1, HSP90A, HSPC1Heat shock protein HSP 90-alphaHSP90AA1ratio: 1.760327339
A2003 HS90B_HUMANHSP90AB1, HSP90B, HSPC2Heat shock protein 90kDa alpha (cytosolic), class B member 1HSP90AB1ratio: 1.252547324
A2007 HSP71_HUMANHSPA1A, HSPA1B, HSPA1Heat shock 70 kDa protein 1HSPA1Aratio: 0.650941133
A4856 HSPB1_HUMANHSPB1, HSP27, HSP28Heat shock protein beta-1HSPB1ratio: 0.558929622
A4347 HSPB6_HUMANHSPB6Heat-shock protein beta-6HSPB6ratio: 0.500662386
A4348 HSPB7_HUMANHSPB7, CVHSPHeat-shock protein, beta-7HSPB7ratio: 0.570125133
A540D HTR5A_HUMANHEATR5AHEAT repeat-containing protein 5AIGHMratio: 0.430064519
A3663 HXK1_HUMANHK1-tc, HK1-tb, HK1-taHexokinase 1HK1ratio: 1.380804658
A6760 HXK2_HUMANHK2Hexokinase, type IIHK2ratio: 1.854976018
A4350 HYOU1_HUMANHYOU1, GRP170, ORP150Hypoxia up-regulated protein 1 precursorHYOU1ratio: 0.892019947
A1591 IC1_HUMANSERPING1, C1IN, C1NHSerine/cysteine proteinase inhibitor clade G member 1SERPING1ratio: 0.712253868
A3661 IDHC_HUMANIDH1, PICDIsocitrate dehydrogenase [NADP] cytoplasmicIDH1ratio: 2.210584005
A3660 IDHP_HUMANIDH2, IDH, IDPIsocitrate dehydrogenase [NADP], mitochondrial precursorIDH2ratio: 1.42651999
A3206 IKIP_HUMANIKBIP, IKIP, IKIP2Inhibitor of nuclear factor kappa-B kinase-interacting proteinSLC25A3ratio: 1.504989028
A8420 ILEU_HUMANSERPINB1, ELANH2, MNEILeukocyte elastase inhibitorSERPINB1ratio: 1.15562733
A6789 IMDH2_HUMANIMPDH2, IMPD2Inosine-5'-monophosphate dehydrogenase 2IMPDH2ratio: 1.793873707
A3973 IMMT_HUMANIMMT, HMP, PIG4Mitochondrial inner membrane proteinIMMTratio: 1.061817785
A6804 IPYR_HUMANPPA1, IOPPP, PPInorganic pyrophosphatasePPA1ratio: 1.206822475
A0213 IQGA1_HUMANIQGAP1Ras GTPase-activating-like protein IQGAP1IQGAP1ratio: 0.833273292
A1694 ITA1_HUMANITGA1, PELOIntegrin alpha-1ITGA1ratio: 0.371350542
A0474 ITA5_HUMANITGA5, FNRAIntegrin alpha-5 precursorITGA5ratio: 0.318909396
A1528 ITA6_HUMANITGA6Integrin alpha-6GFPT1ratio: 2.543507934
A1693 ITA7_HUMANITGA7, UNQ406/PRO768Integrin alpha-7 precursorITGA7ratio: 0.555706531
A0099 ITB1_HUMANITGB1, FNRB, MDF2Integrin beta-1 precursorITGB1ratio: 0.218280301
A8431 ITIH1_HUMANITIH1, IGHEP1, PRO2769Inter-alpha (globulin) inhibitor H1ITIH1ratio: 1.888838013
A8432 ITIH2_HUMANITIH2, IGHEP2Inter-alpha-trypsin inhibitor heavy chain H2 precursorITIH2ratio: 1.195463677
A8434 ITIH4_HUMANITIH4, IHRP, ITIHL1Inter-alpha-trypsin inhibitor heavy chain H4 precursorITIH4ratio: 1.132392466
A9965 ITLN1_HUMANITLN1, INTL, ITLNIntelectin 1ITLN1ratio: 2.01915729
A615D K1755_HUMAN Hypothetical proteinTGM2ratio: 1.205450833
A3824 K1C10_HUMANKRT10, KPPKeratin, type I cytoskeletal 10KRT10ratio: 0.386499266
A3787 K1C19_HUMANKRT19, K19Keratin, type I cytoskeletal 19KRT19ratio: 0.552677611
A0338 K1C20_HUMANKRT20Keratin, type I cytoskeletal 20KRT20ratio: 0.912550092
A3829 K1C9_HUMANKRT9Keratin, type I cytoskeletal 9KRT9ratio: 0.611111244
A3849 K2C1_HUMANKRT1, KRTAKeratin, type II cytoskeletal 1KRT1ratio: 0.520473828
A3848 K2C7_HUMANKRT7, SCLKeratin, type II cytoskeletal 7KRT7ratio: 0.113641242
A3861 K2C78_HUMANKRT78, K5B, KB40Keratin, type II cytoskeletal 78KRT8ratio: 0.517198861
A1925 K6PL_HUMANPFKLPhosphofructokinase, liverPFKLratio: 3.013916015
A622D KANK2_HUMANKANK2, ANKRD25, MXRA3Ankyrin repeat domain-containing protein 25KANK2ratio: 0.605656971
A2286 KCD12_HUMANKCTD12, PFET1BTB/POZ domain-containing protein KCTD12KCTD12ratio: 1.210678518
A3693 KCRB_HUMANCKB, CKBBCreatine kinase B-typeCKBratio: 0.436066906
A2278 KCTD6_HUMANKCTD6Potassium channel tetramerisation domain containing 6PDHBratio: 3.042057673
A3531 KTN1_HUMANKTN1, CG1, PDIA6KinectinPDIA6ratio: 0.797586381
A3531 KTN1_HUMANKTN1, CG1, PDIA6KinectinKTN1ratio: 0.624932527
A1560 LAMA5_HUMANLAMA5Laminin subunit alpha-5LAMA5ratio: 0.72572721
A1508 LAMB1_HUMANLAMB1Laminin subunit beta-1LAMB1ratio: 0.441561321
A1517 LAMB2_HUMANLAMB2, LAMSLaminin beta-2 chain precursorLAMB2ratio: 0.530099849
A1518 LAMC1_HUMANLAMC1, LAMB2Laminin gamma-1 chain precursorLAMC1ratio: 0.421459427
A0370 LDHA_HUMANLDHA, PIG19L-lactate dehydrogenase A chainLDHAratio: 3.188985983
A651D LEG4_HUMANLGALS4Galectin-4LGALS4ratio: 1.358598669
A4004 LETM1_HUMANLETM1Leucine zipper-EF-hand containing transmembrane protein 1, mitochondrialLETM1ratio: 1.369358997
A4941 LG3BP_HUMANLGALS3BP, M2BPGalectin-3-binding protein precursorLGALS3BPratio: 3.710464954
A0430 LMNB1_HUMANLMNB1, LMN2, LMNBLamin B1LMNB1ratio: 0.56852595
A2492 LMNB2_HUMANLMNB2, LMN2Lamin B2LMNB2ratio: 0.310513869
A665D LMO7_HUMANLMO7, FBX20, FBXO20LIM domain only protein 7LMO7ratio: 1.301059007
A3999 LPPRC_HUMANLRPPRC, LRP130Leucine-rich PPR-motif containing proteinLRPPRCratio: 2.198239008
B9054 LRC38_HUMANLRRC38Leucine-rich repeat-containing protein 38EPRSratio: 1.015594045
A4951 LUM_HUMANLUM, LDC, SLRR2DLumican precursorLUMratio: 0.922808806
A6929 LYAG_HUMANGAALysosomal alpha-glucosidase precursorGAAratio: 0.972264329
A6992 MDHC_HUMANMDH1, MDHAMalate dehydrogenase, cytoplasmicMDH1ratio: 0.450076421
A3696 MDHM_HUMANMDH2Malate dehydrogenase, mitochondrial precursorMDH2ratio: 5.152506033
A1655 MMP9_HUMANMMP9, CLG4BMatrix metalloproteinase-9MMP9ratio: 0.742024759
B9897 MOT8_HUMANSLC16A2, MCT8, XPCTSolute carrier family 16, member 2PGK1ratio: 0.426597198
A3949 MTCH2_HUMANMTCH2, MIMP, HSPC032Mitochondrial carrier homolog 2MTCH2ratio: 3.544248978
A7084 MTNB_HUMANAPIP, CGI-29, MMRP19Methylthioribulose-1-phosphate dehydrataseAPIPratio: 2.287728985
A4986 MUC1_HUMANMUC1, PUMMucin-1MUC1ratio: 2.435735702
A4991 MUC18_HUMANMCAM, MUC18Cell surface glycoprotein MUC18 precursorMCAMratio: 0.3204045
A4992 MUC2_HUMANMUC2, mucin, MLPMucin 2 precursorMUC2ratio: 0.578118155
A2616 MUC5A_HUMANMUC5AC, MUC5, MUC 5ACMucin 5ACCCT4ratio: 2.836455345
A156C MVP_HUMANMVP, LRPMajor vault proteinMVPratio: 1.361357013
A2331 MYH11_HUMANMYH11, SMMHCMyosin heavy chain, smooth muscle isoformMYH11ratio: 0.154473166
A3962 MYH14_HUMANMYH14, FP17425Myosin-14MYH14ratio: 0.378533363
A3166 MYH9_HUMANMYH9Myosin heavy chain 9, non-muscleMYH9ratio: 0.530488501
A4049 MYL6_HUMANMYL6, MLC3nm, LC17AMyosin light polypeptide 6MYL6ratio: 0.273001641
A166C MYL9_HUMANMYL9, MLC2, MRLC1Myosin regulatory light polypeptide 9MYL9ratio: 0.294366032
A7110 NAMPT_HUMANNAMPT, NAMPTL, PBEFNicotinamide phosphoribosyltransferaseNAMPTratio: 1.22958529
A7119 NB5R1_HUMANCYB5R1, NQO3A2, UNQ3049/PRO9865NADH-cytochrome b5 reductase 1CYB5R1ratio: 2.177000006
A3561 NDUS1_HUMANNDUFS1, PRO1304NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursorNDUFS1ratio: 1.435311993
A3564 NDUS3_HUMANNDUFS3NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrialNDUFS3ratio: 2.105626384
A224C NGAL_HUMANLCN2, HNL, NGALNeutrophil gelatinase-associated lipocalin precursorLCN2ratio: 0.839914322
A1585 NID1_HUMANNID1, NIDNidogen-1NID1ratio: 0.70660303
A5008 NID2_HUMANNID2Nidogen-2NID2ratio: 0.652546028
A2536 NUCL_HUMANNCLNucleolinNCLratio: 0.511123111
A3664 ODO1_HUMANOGDH2-oxoglutarate dehydrogenase E1 component, mitochondrial precursorOGDHratio: 2.178239346
A5018 OLFM4_HUMANOLFM4, GW112, UNQ362/PRO698Olfactomedin-4OLFM4ratio: 1.42124033
A7262 P5CS_HUMANALDH18A1, GSAS, P5CSDelta 1-pyrroline-5-carboxylate synthetaseALDH18A1ratio: 0.945455313
A1271 PALLD_HUMANPALLD, CGI-151, MYNPalladinPALLDratio: 0.53214703
A1312 PARP1_HUMANPARP1, ADPRT, PPOLPoly [ADP]-ribose polymerase-1PARP1ratio: 0.829765439
A838A PDCD4_HUMANPDCD4, H731Programmed cell death 4PDCD4ratio: 1.095579664
A1816 PDIA3_HUMANPDIA3, ERP57, ERP60Protein disulfide isomerase A3 precursorPDIA3ratio: 0.942115426
A7340 PDIA4_HUMANPDIA4, ERP70, ERP72Protein disulfide isomerase A4 precursorPDIA4ratio: 0.848536074
A9740 PDLI7_HUMANPDLIM7, ENIGMAEnigma proteinPDLIM7ratio: 0.450474779
A8448 PEDF_HUMANSERPINF1, PEDF, PIG35Pigment epithelium-derived factor precursorSERPINF1ratio: 1.157349666
A7359 PERE_HUMANEPX, EPER, EPOEosinophil peroxidase precursorEPXratio: 0.214820971
A0459 PERI_HUMANPRPH, NEF4, PRPH1PeripherinPRPHratio: 0.567072729
A7361 PERM_HUMANMPOMyeloperoxidase precursorMPOratio: 0.467526197
A1555 PGBM_HUMANHSPG2Basement membrane-specific heparan sulfate proteoglycan core proteinHSPG2ratio: 0.382143805
BC313 PI5PA_HUMANINPP5J, PIB5PA, PIPPPhosphatidylinositol 4,5-bisphosphate 5-phosphatase ASMTNratio: 0.329742561
A1941 PLEC_HUMANPLEC1, PLECPlectinPLECratio: 0.582621098
A5085 PLSI_HUMANPLS1Plastin 1, I isoformPLS1ratio: 1.136890928
A5086 PLSL_HUMANLCP1, PLS2Plastin-2LCP1ratio: 0.386610965
A7447 PNCB_HUMANNAPRT1, FHIP, PP3856Nicotinate phosphoribosyltransferase-like proteinNAPRT1ratio: 2.468943357
A5090 POSTN_HUMANPOSTN, OSF2, OSF-2Periostin, osteoblast specific factorPOSTNratio: 1.287179669
A4370 PPIB_HUMANPPIB, CYPBPeptidyl-prolyl cis-trans isomerase B precursorPPIBratio: 0.885866364
A5096 PRELP_HUMANPRELP, SLRR2A, MST161Prolargin precursorPRELPratio: 1.468884985
A1284 PRKDC_HUMANPRKDC, HYRC, HYRC1DNA-dependent protein kinase catalytic subunitPRKDCratio: 1.674624006
A9534 PRP8_HUMANPRPF8, PRPC8, HPRP8Pre-mRNA-processing-splicing factor 8PRPF8ratio: 0.918198963
A7518 PSA1_HUMANPSMA1, HC2, NUProteasome subunit alpha type 1PSMA1ratio: 1.311949333
A887A PTRF_HUMANPTRF, FKSG13Polymerase I and transcript release factorPTRFratio: 0.398564468
A7558 PUR9_HUMANATIC, PURHBifunctional purine biosynthesis protein PURHATICratio: 3.415553331
A3588 PYGB_HUMANPYGBGlycogen phosphorylase, brain formPYGBratio: 0.94244659
A3676 QCR1_HUMANUQCRC1Ubiquinol-cytochrome C reductase complex core protein I, mitochondrial precursorUQCRC1ratio: 3.281323989
A3677 QCR2_HUMANUQCRC2Cytochrome B-C1 complex subunit 2, mitochondrialUQCRC2ratio: 2.34486266
A0152 RAN_HUMANRAN, ARA24, TC4GTP-binding nuclear protein RANRANratio: 7.507692496
A1136 ROA2_HUMANHNRNPA2B1, HNRPA2B1Heterogeneous nuclear ribonucleoproteins A2/B1HNRNPA2B1ratio: 2.874943018
A3639 RPN1_HUMANRPN1Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 67 kDa subunit precursorRPN1ratio: 0.662991941
A369C RRBP1_HUMANRRBP1Ribosome-binding protein 1RRBP1ratio: 0.56690232
A375C S12A2_HUMANSLC12A2, NKCC1Solute carrier family 12 member 2SLC12A2ratio: 1.20537432
A1597 SAMP_HUMANAPCS, PTX2Serum amyloid P-component precursorAPCSratio: 0.896089057
A463C SBP1_HUMANSELENBP1, SBPSelenium-binding protein 1SELENBP1ratio: 1.291375001
A3770 SCMC1_HUMANSLC25A24, APC1, MCSC1Solute carrier family 25 member 24SLC25A24ratio: 1.156589667
A495C SDPR_HUMANSDPRSerum deprivation response proteinSDPRratio: 0.410522958
BE726 SEBOX_HUMANSEBOX, OG9XHomeobox protein SEBOXVTNratio: 3.202051878
A1014 SFPQ_HUMANSFPQ, PSFSplicing factor, proline-and glutamine-richSFPQratio: 1.817679644
A313E SH3L1_HUMANSH3BGRLSH3 domain-binding glutamic acid-rich-like proteinSH3BGRLratio: 0.401351144
A3788 SND1_HUMANSND1, TDRD11Staphylococcal nuclease domain containing protein 1SND1ratio: 2.46725901
A9060 SORCN_HUMANSRISorcinSRIratio: 1.188364069
A8502 SPB5_HUMANSERPINB5, PI5Maspin precursorSERPINB5ratio: 0.66915376
A0010 SPTB2_HUMANSPTBN1, SPTB2, RPL23AP13Spectrin beta chain, brain 1SPTBN1ratio: 0.688474536
A5151 SPTN1_HUMANSPTAN1, SPTA2, NEASSpectrin alpha chain, brainSPTAN1ratio: 0.51288266
A7863 SQRD_HUMANSQRDL, CGI-44, PRO1975Sulfide:quinone oxidoreductase, mitochondrial precursorSQRDLratio: 0.441532045
A0100 SRBS1_HUMANSORBS1, CAP, SH3P12Sorbin and SH3 domain containing 1SORBS1ratio: 0.288549989
A2598 SRRM2_HUMANSRRM2, SRL300, SRM300Serine/arginine repeptitive matrix protein 2SRRM2ratio: 0.873079479
A0719 STAT1_HUMANSTAT1Signal transducer and activator of transcription 1-alpha/betaSTAT1ratio: 0.6671441
A0492 STIP1_HUMANSTIP1Stress-induced-phosphoprotein 1STIP1ratio: 1.159957012
A7900 SUCB2_HUMANSUCLG2Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial precursorSUCLG2ratio: 1.432061354
A7912 SYDC_HUMANDARS, PIG40Aspartyl-tRNA synthetaseDARSratio: 1.834277351
A7915 SYEP_HUMANEPRS, GLNS, PARSBifunctional aminoacyl-tRNA synthetaseQARSratio: 1.74508365
A7922 SYIC_HUMANIARS, PRO0785Isoleucyl-tRNA synthetase, cytoplasmicIARSratio: 1.070639332
A5169 SYNEM_HUMANSYNM, DMN, SYNSyneminSYNMratio: 0.215948333
A5170 SYNP2_HUMANSYNPO2, MYOPODINSynaptopodin 2SYNPO2ratio: 0.300854604
A7933 SYSC_HUMANSARS, SERSSeryl-tRNA synthetase, cytoplasmicSARSratio: 1.163159688
A7941 SYWC_HUMANWARS, IFI53, WRSTryptophanyl-tRNA synthetase, cytoplasmicWARSratio: 0.512972862
A5174 TAGL_HUMANTAGLN, SM22, WS3-10TransgelinTAGLNratio: 0.895541251
A371E TAGL2_HUMANTAGLN2, CDABP0035Transgelin 2TAGLN2ratio: 2.244471391
A3541 TCPA_HUMANTCP1, CCT1, CCTAT-complex protein 1, alpha subunitTCP1ratio: 2.115152995
A3540 TCPB_HUMANCCT2, 99D8.1, CCTBT-complex protein 1, beta subunitCCT2ratio: 1.856321971
A3543 TCPE_HUMANCCT5, CCTE, PNAS-102T-complex protein 1, epsilon subunitCCT5ratio: 1.72952795
A3544 TCPG_HUMANCCT3, CCTG, TRIC5T-complex protein 1, gamma subunitCCT3ratio: 1.970029036
A3539 TCPH_HUMANCCT7, CCTH, NIP7-1T-complex protein 1, eta subunitCCT7ratio: 1.665749351
A3542 TCPQ_HUMANCCT8, CCTQT-complex protein 1, theta subunitCCT8ratio: 1.95084401
A1525 TENA_HUMANTNC, HXBTenascin precursorTNCratio: 0.403513302
A1301 TGFI1_HUMANTGFB1I1, ARA55, Hic-5Transforming growth factor beta 1 induced transcript 1TGFB1I1ratio: 0.622317235
A9106 THIO_HUMANTXN delta 3, TXN, TRDXThioredoxinTXNratio: 1.796812654
A1469 THRB_HUMANF2Prothrombin precursorF2ratio: 1.410243313
A0097 TLN1_HUMANTLN1, TLNTalin 1TLN1ratio: 0.367303709
A127B TR150_HUMANTHRAP3, TRAP150Thyroid hormone receptor-associated protein 3THRAP3ratio: 0.742793063
A1712 TRFL_HUMANLTF, LF, GIG12Lactotransferrin precursorLTFratio: 0.555242558
A8080 TYPH_HUMANTYMP, ECGF1Thymidine phosphorylase precursorTYMPratio: 0.783629338
A2150 U520_HUMANSNRNP200, ASCC3L1, HELIC2U5 small nuclear ribonucleoprotein 200 kDa helicaseSNRNP200ratio: 1.079284787
A8092 UBA1_HUMANUBA1, UBE1, A1S9TUbiquitin-activating enzyme E1UBA1ratio: 1.206383983
A0425 VDAC1_HUMANVDAC1, VDAC, VDAC4Voltage-dependent anion-selective channel protein 1VDAC1ratio: 2.956311941
A5242 VILI_HUMANVIL1, VILVillin 1VIL1ratio: 1.92727832
A0850 VIME_HUMANVIMVimentinVIMratio: 1.314914743
A0098 VINC_HUMANVCLVinculinVCLratio: 0.204719732
A3909 VPS35_HUMANVPS35, MEM3Vacuolar protein sorting-associated protein 35VPS35ratio: 1.330196659
A9151 VWA1_HUMANVWA1, WARPVon Willebrand factor A domain-containing protein 1VWA1ratio: 0.669543187
A1521 VWF_HUMANVWF, F8VWFVon Willebrand factor precursorVWFratio: 0.492775043
A0777 XRCC5_HUMANXRCC5, G22P2, KARP-1X-ray repair cross-complementing protein 5XRCC5ratio: 1.603177349
A0716 XRCC6_HUMANXRCC6, G22P1X-ray repair cross-complementing protein 6XRCC6ratio: 1.449271003
A195A ZA2G_HUMANAZGP1, ZAG, ZNGP1Zinc-alpha-2-glycoprotein precursorAZGP1ratio: 0.972642541
A0429 ACON_HUMANACO2Aconitate hydratase, mitochondrial precursorACO2ratio: 0.999931236
A0340 AT1A1_HUMANATP1A1Sodium/potassium-transporting ATPase alpha-1 chain precursorATP1A1ratio: 0.613645156
BJ443 BL1S5_HUMANBLOC1S5, MUTED, BLOC1S5-TXNDC5Muted protein homologTXNDC5ratio: 0.663403451
A4629 CALD1_HUMANCALD1, CAD, CDMCaldesmonCALD1ratio: 0.168235302
A541A HMGA2_HUMANHMGIC, HMGA2, HMGA2DHigh mobility group protein HMGI-CHMGA2ratio: 5.385189772
A1631 HPT_HUMANHPHaptoglobin precursorHPratio: 1.004028221
A1577 K1C18_HUMANKRT18, CYK18, PIG46Keratin, type I cytoskeletal 18KRT18ratio: 0.866985659
A0778 MAP4_HUMANMAP4Microtubule-associated protein 4MAP4ratio: 0.443107784
A9994 MIME_HUMANOGN, OIF, SLRR3AMimecan precursorOGNratio: 0.404498537
A1004 MYPT1_HUMANPPP1R12A, MBS, MYPT1Protein phosphatase 1 regulatory (inhibitor) subunit 12APPP1R12Aratio: 0.547398835
A757D NUCKS_HUMANNUCKS1, NUCKS, JC7Nuclear ubiquitous casein and cyclin-dependent kinases substrateNUCKS1ratio: 0.838035067
A1733 PDIA1_HUMANP4HB, ERBA2L, PDIProtein disulfide isomerase precursorP4HBratio: 0.666459262
A0325 TENS1_HUMANTNS1, TNSTensin-1TNS1ratio: 0.340091606
A643C TRFE_HUMANTF, PRO1400Serotransferrin precursorTFratio: 0.376684467
A681C VIGLN_HUMANHDLBP, HBP, VGLVigilinHDLBPratio: 0.76315256

Compile date 10-20-2017© .