MoCadb-logoMoCadb - Study ID Exp25143946

PubMed ID25143946
AuthorsDella Vittoria Scarpati G(1), Calura E(2), Di Marino M(3), Romualdi C(2), Beltrame L(3), Malapelle U(4), Troncone G(4), De Stefano A(1), Pepe S(5), De Placido S(1), D'Incalci M(3), Marchini S(3), Carlomagno C(1).
TitleAnalysis of differential miRNA expression in primary tumor and stroma of colorectal cancer patients
JournalBiomed Res Int. 2014;2014:840921.
AbstractMicroarray technology was used to profile miRNA expression in primary tumor and stromal tissue from paraffin embedded material of 51 patients with colorectal cancer. 26 miRNAs resulted differentially expressed with at least 2-fold change in tumor tissue with respect to stroma (16 more expressed in the tumor and 10 more expressed in the stroma). 10/26 were confirmed as differentially expressed at qRTPCR: miR-200c-3p, miR-141-3p, miR-200b-3p, miR-200a-3p, miR-1246, miR-92a-3p, miR-194-5p, miR-192-5p, miR-3651-5p, and miR-574-3p. No significant association was found between miRNA expressions and stage at diagnosis, site of primary tumor, first site of metastasis, progression-free, or overall survival.

Sample characteristics

SpeciesTissue / SourceDiseaseNDetection methodSample
Homo sapienscolon_rectumColorectal cancer (CRC)57miRNA MicroarrayDem25143946

Sample description and preparation

Disease (case)Colorectal cancer (CRC)
Disease (control)matched stroma

Sample detection

PlatformG13 human miRNA microarray kit (Agilent Technologies)

Sample analysis

Software thresholdFDR<0.05

Molecule list

Molecule IDextExternal IDGeneNameSource accRegulation (case/control)Scores
AZ02J ENSG00000199017MIR1-1Homo sapiens miR-1-1 stem-loophsa-miR-1ratio log2fc: -1.3411554p-value: 0.0000103
AZ41E MIMAT0018079 hsa-miR-1273ehsa-miR-1273eratio log2fc: 0.63067662p-value: 0.000275
AZ068 ENSG00000221355MIR1288Homo sapiens miR-1288 stem-loophsa-miR-1288ratio log2fc: 0.42586448p-value: 0.00665
AZ0H2 ENSG00000265142MIR133A1Homo sapiens miR-133a-1 stem-loophsa-miR-133aratio log2fc: -0.8510897p-value: 0.0000199
BZ1AE MIMAT0018068 hsa-miR-3648hsa-miR-3648ratio log2fc: 0.50113222p-value: 0.0000287
AZ0M9 ENSG00000199038MIR210Homo sapiens miR-210 stem-loophsa-miR-210ratio log2fc: 1.19299762p-value: 0.000014
BZ2A8 MIMAT0018005 hsa-miR-3622b-5phsa-miR-3622b-5pratio log2fc: 0.35039945p-value: 0.00594
AZ0N4 ENSG00000207590MIR215Homo sapiens miR-215 stem-loophsa-miR-215ratio log2fc: 1.507275p-value: 0.00000289
BZ323 ENSG00000252695MIR2276Homo sapiens miR-2276 stem-loophsa-miR-2276ratio log2fc: 0.39230797p-value: 0.0119
BZ3A6 MIMAT0018179 hsa-miR-3907hsa-miR-3907ratio log2fc: -0.5207543p-value: 0.000184
BZ3BA MIMAT0018074 hsa-miR-3654hsa-miR-3654ratio log2fc: 0.65584834p-value: 0.000000918
AZ11T ENSG00000266509MIR3934Homo sapiens miR-3934 stem-loophsa-miR-3934ratio log2fc: 0.43734049p-value: 0.00162
BZ7AR MIMAT0018071 hsa-miR-3651hsa-miR-3651ratio log2fc: 1.28775706p-value: 3.74E-10
BZ9AL MIMAT0018121 hsa-miR-3692-5phsa-miR-3692-5pratio log2fc: 0.35980468p-value: 0.00786
AZ1A5 ENSG00000194717MIR494Homo sapiens miR-494 stem-loophsa-miR-494ratio log2fc: 0.63509731p-value: 0.00000789
AZ1BQ ENSG00000207871MIR513BHomo sapiens miR-513b stem-loophsa-miR-513bratio log2fc: 0.40353173p-value: 0.012
AZ1LB MI0006654MIR720Homo sapiens miR-720 stem-loophsa-miR-720ratio log2fc: -0.7269849p-value: 7.03E-08
AZ1PU ENSG00000216077MIR887Homo sapiens miR-887 stem-loophsa-miR-887ratio log2fc: 0.36932201p-value: 0.0162
AZ2WH MIMAT0004957 hsa-miR-760hsa-miR-760ratio log2fc: 0.30644162p-value: 0.00972
AZ42A MIMAT0000443 hsa-miR-125a-5phsa-miR-125a-5pratio log2fc: -0.6265232p-value: 0.000616
AZ3NB MIMAT0000085 hsa-miR-28-5phsa-miR-28-5pratio log2fc: -0.6793453p-value: 0.000878
AZ3JH MIMAT0000087 hsa-miR-30a-5phsa-miR-30a-5pratio log2fc: -0.7528979p-value: 0.00111
AZ3FX MIMAT0000753 hsa-miR-342-3phsa-miR-342-3pratio log2fc: -0.4853416p-value: 0.011
AZ21Y MIMAT0003393 hsa-miR-425-5phsa-miR-425-5pratio log2fc: 0.80064141p-value: 0.00000189
AZ39W MIMAT0002872 hsa-miR-501-5phsa-miR-501-5pratio log2fc: 0.29796413p-value: 0.00108
AZ34G MIMAT0003239 hsa-miR-574-3phsa-miR-574-3pratio log2fc: -1.9115869p-value: 1.26E-11
AZ2SM MIMAT0000092 hsa-miR-92a-3phsa-miR-92a-3pratio log2fc: 1.06291954p-value: 4.64E-08
AZ29W MIMAT0000066 hsa-let-7e-5phsa-let-7e-5pratio log2fc: -0.6073244p-value: 0.0113
AZ33B MIMAT0000098 hsa-miR-100-5phsa-miR-100-5pratio log2fc: -0.8581824p-value: 0.000626
AZ451 MIMAT0000680 hsa-miR-106b-5phsa-miR-106b-5pratio log2fc: 0.82944936p-value: 0.000213
AZ426 MIMAT0000423 hsa-miR-125b-5phsa-miR-125b-5pratio log2fc: -0.8449698p-value: 0.00182
AZ3ZT MIMAT0000425 hsa-miR-130a-3phsa-miR-130a-3pratio log2fc: -0.619278p-value: 0.0129
AZ3ZR MIMAT0000691 hsa-miR-130b-3phsa-miR-130b-3pratio log2fc: 0.59123284p-value: 0.0000308
AZ3Z5 MIMAT0000770 hsa-miR-133bhsa-miR-133bratio log2fc: -1.5123276p-value: 0.00000228
AZ3XS MIMAT0000432 hsa-miR-141-3phsa-miR-141-3pratio log2fc: 2.22388859p-value: 1.44E-09
AZ3XK MIMAT0000435 hsa-miR-143-3phsa-miR-143-3pratio log2fc: -1.4333531p-value: 0.0000266
AZ3XE MIMAT0000437 hsa-miR-145-5phsa-miR-145-5pratio log2fc: -1.7477164p-value: 0.0000122
AZ3X3 MIMAT0000449 hsa-miR-146a-5phsa-miR-146a-5pratio log2fc: 0.54119911p-value: 0.00123
AZ3WQ MIMAT0000243 hsa-miR-148a-3phsa-miR-148a-3pratio log2fc: 0.93546999p-value: 0.000123
AZ3WL MIMAT0000450 hsa-miR-149-5phsa-miR-149-5pratio log2fc: -0.5186715p-value: 0.00727
AZ3WH MIMAT0000451 hsa-miR-150-5phsa-miR-150-5pratio log2fc: -0.6155731p-value: 0.00871
AZ1TJ MIMAT0000256 hsa-miR-181a-5phsa-miR-181a-5pratio log2fc: 0.52688825p-value: 0.00851
AZ2DC MIMAT0000222 hsa-miR-192-5phsa-miR-192-5pratio log2fc: 1.83444059p-value: 0.000000525
AZ2DK MIMAT0002819 hsa-miR-193b-3phsa-miR-193b-3pratio log2fc: -0.3476182p-value: 0.0193
AZ2DM MIMAT0000460 hsa-miR-194-5phsa-miR-194-5pratio log2fc: 1.79583132p-value: 0.00000107
AZ2DT MIMAT0000461 hsa-miR-195-5phsa-miR-195-5pratio log2fc: -1.3352339p-value: 0.00000454
AZ2E5 MIMAT0000227 hsa-miR-197-3phsa-miR-197-3pratio log2fc: -1.1483022p-value: 1.47E-10
AZ2ES MIMAT0000073 hsa-miR-19a-3phsa-miR-19a-3pratio log2fc: 0.94241736p-value: 0.0000133
AZ2EU MIMAT0000074 hsa-miR-19b-3phsa-miR-19b-3pratio log2fc: 1.00428691p-value: 0.00000148
AZ2FO MIMAT0000682 hsa-miR-200a-3phsa-miR-200a-3pratio log2fc: 1.67832962p-value: 1.05E-08
AZ2FR MIMAT0000318 hsa-miR-200b-3phsa-miR-200b-3pratio log2fc: 2.40063273p-value: 1.51E-09
AZ2FS MIMAT0000617 hsa-miR-200c-3phsa-miR-200c-3pratio log2fc: 2.15323075p-value: 6.13E-11
AZ2G6 MIMAT0000264 hsa-miR-203a-3phsa-miR-203ratio log2fc: 0.89749749p-value: 0.00000095
AZ2HK MIMAT0000075 hsa-miR-20a-5phsa-miR-20a-5pratio log2fc: 1.14909454p-value: 0.00000088
AZ2HO MIMAT0000076 hsa-miR-21-5phsa-miR-21-5pratio log2fc: 0.61990861p-value: 0.0178
AZ3TW MIMAT0000271 hsa-miR-214-3phsa-miR-214-3pratio log2fc: -0.618092p-value: 0.00764
AZ3SQ MIMAT0000077 hsa-miR-22-3phsa-miR-22-3pratio log2fc: -0.5594921p-value: 0.00599
AZ3PU MIMAT0000081 hsa-miR-25-3phsa-miR-25-3pratio log2fc: 0.58161406p-value: 0.00121
AZ3LR MIMAT0000086 hsa-miR-29a-3phsa-miR-29a-3pratio log2fc: 0.65085436p-value: 0.00395
AZ3JB MIMAT0000244 hsa-miR-30c-5phsa-miR-30c-5pratio log2fc: -0.5709735p-value: 0.00295
AZ25A MIMAT0000710 hsa-miR-365a-3phsa-miR-365a-3pratio log2fc: -0.8131199p-value: 0.0000053
AZ24B MIMAT0000728 hsa-miR-375hsa-miR-375ratio log2fc: 0.5870943p-value: 0.00438
AZ21V MIMAT0001536 hsa-miR-429hsa-miR-429ratio log2fc: 1.51819183p-value: 5.59E-08
AZ3CE MIMAT0002174 hsa-miR-484hsa-miR-484ratio log2fc: -0.2018072p-value: 0.0151
AZ3AH MIMAT0002820 hsa-miR-497-5phsa-miR-497-5pratio log2fc: -0.9887135p-value: 0.0000203
AZ323 MIMAT0003286 hsa-miR-617hsa-miR-617ratio log2fc: 0.34973524p-value: 0.00296
AZ31Y MIMAT0003291 hsa-miR-622hsa-miR-622ratio log2fc: 0.63586832p-value: 0.000324
AZ2ZX MIMAT0003326 hsa-miR-663ahsa-miR-663aratio log2fc: 0.80827814p-value: 0.000000806
AZ2W8 MIMAT0003945 hsa-miR-765hsa-miR-765ratio log2fc: 0.51110139p-value: 0.000613
BZP97 MIMAT0016875 hsa-miR-4323hsa-miR-4323ratio log2fc: -0.2765802p-value: 0.00864
AZ2SC MIMAT0000093 hsa-miR-93-5phsa-miR-93-5pratio log2fc: 0.8305619p-value: 0.0000689
AZ1TX MIMAT0000097 hsa-miR-99a-5phsa-miR-99a-5pratio log2fc: -0.9752663p-value: 0.000181
AZ1TT MIMAT0000689 hsa-miR-99b-5phsa-miR-99b-5pratio log2fc: -0.8048456p-value: 0.000069
AZ44E MIMAT0005826 hsa-miR-1181hsa-miR-1181ratio log2fc: 0.39604356p-value: 0.00546
AZ43J MIMAT0005572 hsa-miR-1225-5phsa-miR-1225-5pratio log2fc: 0.25302243p-value: 0.00818
AZ431 MIMAT0005898 hsa-miR-1246hsa-miR-1246ratio log2fc: 1.08433315p-value: 1.38E-08
AZ42B MIMAT0004602 hsa-miR-125a-3phsa-miR-125a-3pratio log2fc: 0.36111173p-value: 0.000817
AZ421 MIMAT0005911 hsa-miR-1260ahsa-miR-1260aratio log2fc: -1.1570189p-value: 5.46E-09
AZ41S MIMAT0005922 hsa-miR-1268ahsa-miR-1268aratio log2fc: 0.26857158p-value: 0.0116
AZ412 MIMAT0005939 hsa-miR-1281hsa-miR-1281ratio log2fc: -0.7601248p-value: 0.00112
AZ40L MIMAT0005880 hsa-miR-1290hsa-miR-1290ratio log2fc: 0.92604392p-value: 0.000000014
AZ3ZZ MIMAT0005893 hsa-miR-1305hsa-miR-1305ratio log2fc: 0.42968753p-value: 0.00848
AZ3YQ MIMAT0004595 hsa-miR-135a-3phsa-miR-135a-3pratio log2fc: 0.44540427p-value: 0.0151
AZ3XJ MIMAT0004599 hsa-miR-143-5phsa-miR-143-5pratio log2fc: -1.2316102p-value: 0.00000615
AZ3WD MIMAT0000757 hsa-miR-151a-3phsa-miR-151a-3pratio log2fc: 0.37122413p-value: 0.00245
AZ3UU MIMAT0000070 hsa-miR-17-5phsa-miR-17-5pratio log2fc: 1.07625287p-value: 0.00000125
AZ2BL MIMAT0006765 hsa-miR-1825hsa-miR-1825ratio log2fc: -0.8566416p-value: 0.000408
AZ2DJ MIMAT0004614 hsa-miR-193a-5phsa-miR-193a-5pratio log2fc: -0.46089p-value: 0.000744
AZ2DN MIMAT0004671 hsa-miR-194-3phsa-miR-194-3pratio log2fc: 0.21314568p-value: 0.00151
AZ2HN MIMAT0004494 hsa-miR-21-3phsa-miR-21-3pratio log2fc: 0.58285164p-value: 0.00209
AZ3FN MIMAT0000772 hsa-miR-345-5phsa-miR-345-5pratio log2fc: 0.31834636p-value: 0.00368
BZS49 MIMAT0004687 hsa-miR-371a-5phsa-miR-371a-5pratio log2fc: 0.45857366p-value: 0.00241
AZ221 MIMAT0004749 hsa-miR-424-3phsa-miR-424-3pratio log2fc: 0.4557021p-value: 0.00000131
AZ3CF MIMAT0004761 hsa-miR-483-5phsa-miR-483-5pratio log2fc: 0.63806749p-value: 0.000437
AZ3A0 MIMAT0004773 hsa-miR-500a-5phsa-miR-500a-5pratio log2fc: 0.4459759p-value: 0.000108
AZ38Y MIMAT0002877 hsa-miR-513a-5phsa-miR-513a-5pratio log2fc: 0.53220884p-value: 0.00414
AZ38O MIMAT0004770 hsa-miR-516a-5phsa-miR-516a-5pratio log2fc: 0.20627556p-value: 0.0201
AZ34F MIMAT0004795 hsa-miR-574-5phsa-miR-574-5pratio log2fc: -0.5258208p-value: 0.00457
AZ2ZW MIMAT0005867 hsa-miR-663bhsa-miR-663bratio log2fc: 0.77767795p-value: 2.39E-09
AZ2ZT MIMAT0005948 hsa-miR-664a-5phsa-miR-664-5pratio log2fc: 0.52094262p-value: 0.00000527
AZ2U4 MIMAT0004950 hsa-miR-877-3phsa-miR-877-3pratio log2fc: -0.5781655p-value: 0.000353
AZ2T8 MIMAT0004918 hsa-miR-892bhsa-miR-892bratio log2fc: 0.32236508p-value: 0.00274
AZ2S6 MIMAT0004979 hsa-miR-936hsa-miR-936ratio log2fc: 0.28420345p-value: 0.0151
AZ3IO MIMAT0014990 hsa-miR-3127-5phsa-miR-3127-5pratio log2fc: 0.32974723p-value: 0.016
AZ413 MI0006437 hsa-mir-1280hsa-miR-1280ratio log2fc: -0.4568893p-value: 0.00436
BZU28 MIMAT0016858 hsa-miR-4306hsa-miR-4306ratio log2fc: 0.3872522p-value: 0.00617
BZU38 MIMAT0015079 hsa-miR-3195hsa-miR-3195ratio log2fc: -0.3534892p-value: 0.00584
BZU50 MIMAT0016878 hsa-miR-4257hsa-miR-4257ratio log2fc: 0.40102439p-value: 0.0112
BZU53 MIMAT0016851 hsa-miR-4299hsa-miR-4299ratio log2fc: 0.42647189p-value: 0.00248
BZU74 MIMAT0016915 hsa-miR-4284hsa-miR-4284ratio log2fc: 0.60988918p-value: 0.000211
AZ420 MIMAT0015041 hsa-miR-1260bhsa-miR-1260bratio log2fc: -1.1083897p-value: 2.35E-08
BZU88 MIMAT0009448 hsa-miR-1973hsa-miR-1973ratio log2fc: 1.04005254p-value: 0.00000147
AZ3IE MIMAT0015010 hsa-miR-3141hsa-miR-3141ratio log2fc: 0.31184381p-value: 0.0177
BZV04 MIMAT0016876 hsa-miR-4324hsa-miR-4324ratio log2fc: -0.5103669p-value: 0.0000305
BZV05 MIMAT0014988 hsa-miR-3125hsa-miR-3125ratio log2fc: 0.48341626p-value: 0.00715
BZV63 MIMAT0015030 hsa-miR-3156-5phsa-miR-3156-5pratio log2fc: 0.57768219p-value: 0.000956
BZV94 MIMAT0007890 hsa-miR-1914-3phsa-miR-1914-3pratio log2fc: 0.38403477p-value: 0.0182
BZV95 MIMAT0015083 hsa-miR-3198hsa-miR-3198ratio log2fc: 0.5694316p-value: 0.00267
AZ3I6 MIMAT0015028 hsa-miR-3154hsa-miR-3154ratio log2fc: 0.44026642p-value: 0.000145
AZ2W7 MIMAT0003888 hsa-miR-766-3phsa-miR-766-3pratio log2fc: -0.8696977p-value: 0.000000483
AZ38S MIMAT0015087 hsa-miR-514b-5phsa-miR-514b-5pratio log2fc: 0.37778724p-value: 0.0023
BZW23 MIMAT0015089 hsa-miR-3202hsa-miR-3202ratio log2fc: 0.40975378p-value: 0.0048
BZW44 MIMAT0015082 hsa-miR-3197hsa-miR-3197ratio log2fc: 0.2796403p-value: 0.0187
AZ3IK MIMAT0014997 hsa-miR-3132hsa-miR-3132ratio log2fc: 0.34562033p-value: 0.00639
BZW67 MIMAT0015019 hsa-miR-3147hsa-miR-3147ratio log2fc: 0.24731849p-value: 0.00968
BZY52 MIMAT0018065 hsa-miR-3646hsa-miR-3646ratio log2fc: -0.3289688p-value: 0.0042

Compile date 10-20-2017© .