MoCadb-logoMoCadb - Study ID Exp24687888c

PubMed ID24687888
AuthorsKume H(1), Muraoka S(1), Kuga T(1), Adachi J(1), Narumi R(1), Watanabe S(1), Kuwano M(1), Kodera Y(2), Matsushita K(3), Fukuoka J(4), Masuda T(5), Ishihama Y(6), Matsubara H(7), Nomura F(3), Tomonaga T(8).
TitleDiscovery of colorectal cancer biomarker candidates by membrane proteomic analysis and subsequent verification using selected reaction monitoring (SRM) and tissue microarray (TMA) analysis.
JournalMol Cell Proteomics. 2014 Jun;13(6):1471-84.
AbstractRecent advances in quantitative proteomic technology have enabled the large-scale validation of biomarkers. We here performed a quantitative proteomic analysis of membrane fractions from colorectal cancer tissue to discover biomarker candidates, and then extensively validated the candidate proteins identified. A total of 5566 proteins were identified in six tissue samples, each of which was obtained from polyps and cancer with and without metastasis. GO cellular component analysis predicted that 3087 of these proteins were membrane proteins, whereas TMHMM algorithm predicted that 1567 proteins had a transmembrane domain. Differences were observed in the expression of 159 membrane proteins and 55 extracellular proteins between polyps and cancer without metastasis, while the expression of 32 membrane proteins and 17 extracellular proteins differed between cancer with and without metastasis. A total of 105 of these biomarker candidates were quantitated using selected (or multiple) reaction monitoring (SRM/MRM) with stable synthetic isotope-labeled peptides as an internal control. The results obtained revealed differences in the expression of 69 of these proteins, and this was subsequently verified in an independent set of patient samples (polyps (n = 10), cancer without metastasis (n = 10), cancer with metastasis (n = 10)). Significant differences were observed in the expression of 44 of these proteins, including ITGA5, GPRC5A, PDGFRB, and TFRC, which have already been shown to be overexpressed in colorectal cancer, as well as proteins with unknown function, such as C8orf55. The expression of C8orf55 was also shown to be high not only in colorectal cancer, but also in several cancer tissues using a multicancer tissue microarray, which included 1150 cores from 14 cancer tissues. This is the largest verification study of biomarker candidate membrane proteins to date; our methods for biomarker discovery and subsequent validation using SRM/MRM will contribute to the identification of useful biomarker candidates for various cancers. Data are available via ProteomeXchange with identifier PXD000851.

Sample characteristics

SpeciesTissue / SourceCompartmentDiseaseNDetection methodSample
Homo sapienscolon_rectumMembrane FractionsCRC metastasis33LC-MS/MSDem4687888b, Dem4687888c

Sample description and preparation

N (case)16
N (control)17
Disease (case)CRC metastasis
Disease (control)CRC w/o metastasis
Preparation specific methodiTRAQ-labelling
Digestin-solution digestion, Trypsin
SeparationSCX column
Storage condition-80C

Sample analysis

Software analysis toolProteome Discoverer ver.1.3
Software thresholdP<0.1, fold change>2.0

Molecule list

Molecule IDextExternal IDGeneNameSource accRegulation (case/control)Scores
A5669 ACO13_HUMANACOT13, THEM2, HT012Acyl-coenzyme A thioesterase 13Q9NPJ3ratio: 2.306444195
A5708 ADA_HUMANADA, ADA1Adenosine deaminaseP00813ratio: 3.235101846
A8650 AGR2_HUMANAGR2, AG2, UNQ515/PRO1030Secreted cement gland protein XAG-2 homologO95994ratio: 2.563175168
A764C AGR3_HUMANAGR3, BCMP11, UNQ642/PRO1272Anterior gradient protein 3 homologQ8TD06ratio: 2.489430246
A3599 AL1B1_HUMANALDH1B1, ALDH5, ALDHXAldehyde dehydrogenase X, mitochondrialP30837ratio: 2.099090619
A776C AN13A_HUMANANKRD13, ANKRD13A, NY-REN-25Ankyrin repeat domain-containing protein 13AQ8IZ07ratio: 0.493485999
A8661 ANS1A_HUMANANKS1A, ANKS1, ODINAnkyrin repeat and SAM domain containing protein 1AQ92625ratio: 0.290445276
A3672 AOFA_HUMANMAOAAmine oxidase [flavin-containing] AP21397ratio: 2.251294487
A1715 APOA_HUMANAPOA, LPAApolipoprotein(A) precursorP08519ratio: 0.341055175
A810B APOA4_HUMANAPOA4, ApoA-IV, APOA-IVApolipoprotein A-IV precursorP06727ratio: 2.382734577
A2394 ARAP1_HUMANARAP1, CENTD2Centaurin delta 2Q96P48ratio: 0.373185815
A560E AREG_HUMANAREG, SDGF, AREGBAmphiregulin precursorP15514ratio: 0.475341096
A8681 ATIF1_HUMANATPIF1, ATPI, ASIATPase inhibitor, mitochondrial precursorQ9UII2ratio: 2.220308789
A5524 ATX2_HUMANATXN2, ATX2, SCA2Ataxin-2Q99700ratio: 0.469743661
A9786 B2L14_HUMANBCL2L14, BCLGApoptosis facilitator BCL-2-like protein 14Q9BZR8ratio: 2.743335631
A2168 BAZ1B_HUMANBAZ1B, WBSC10, WBSCR10Tyrosine-protein kinase BAZ1BQ9UIG0ratio: 0.466576231
B1424 BCAP_HUMANPIK3AP1, BCAPPhosphoinositide-3-kinase adaptor protein 1Q6ZUJ8ratio: 0.436753993
B1580 BORG5_HUMANCDC42EP1, BORG5, CEP1CDC42 effector protein 1Q00587ratio: 0.29335133
A5937 BPHL_HUMANBPHL, MCNAABiphenyl hydrolase-like proteinQ86WA6ratio: 2.046311955
A1545 C4BPB_HUMANC4BPBC4b-binding protein beta chain precursorP20851ratio: 3.534894696
A1736 C5AR1_HUMANC5AR1, C5AR, C5R1C5a anaphylatoxin chemotactic receptor 1P21730ratio: 0.419658171
A8697 CAR10_HUMANCARD10, CARMA3Caspase recruitment domain protein 10Q9BWT7ratio: 0.464850989
A991C CCD58_HUMANCCDC58Coiled-coil domain-containing protein 58Q4VC31ratio: 2.035188976
B2376 CD123_HUMANCDC123, D123Cell division cycle protein 123 homologO75794ratio: 0.371240344
A1123 CD34_HUMANCD34Hematopoietic progenitor cell antigen CD34 precursorP28906ratio: 0.487814761
B2453 CDC27_HUMANCDC27, ANAPC3, D0S1430ECell division cycle protein 27 homologP30260ratio: 2.830751732
A1680 CEL3A_HUMANELA3A, CELA3A, ELA3Elastase IIIA precursorP09093ratio: 6.192496164
B2720 CGAS_HUMANMB21D1Uncharacterized protein C6ORF150Q8N884ratio: 0.477367218
A4280 CH10_HUMANEPFP1, HSPE110 kDa heat shock protein, mitochondrialP61604ratio: 2.010028897
A089D CHCH1_HUMANCHCHD1, MRPS37Coiled-coil-helix-coiled-coil-helix domain-containing protein 1Q96BP2ratio: 2.533164433
A6076 CLYBL_HUMANCLYBL, CLBCitrate lyase beta like protein, mitochondrialQ8N0X4ratio: 2.104878409
A9841 CMGA_HUMANCHGAChromogranin A precursorP10645ratio: 15.45809606
A8718 CNPY3_HUMANCNPY3, CTG4A, ERDA5Protein Canopy homolog 3 precursorQ9BT09ratio: 2.055465178
A1491 CO1A1_HUMANCOL1A1Collagen alpha-1(I) chainP02452ratio: 0.357729272
A1492 CO1A2_HUMANCOL1A2Collagen alpha 2(I) chain precursorP08123ratio: 0.336612532
A1556 CO3A1_HUMANCOL3A1Collagen alpha 1(III) chain precursorP02461ratio: 0.388050655
B3510 CP3A5_HUMANCYP3A5, CYP3A5P1Cytochrome P450, family 3, subfamily A, polypeptide 5P20815ratio: 2.203915314
A6202 CPSM_HUMANCPS1, CPSICarbamoyl-phosphate synthase [ammonia], mitochondrial precursorP31327ratio: 2.062860516
A6212 CRP_HUMANCRP, PTX1C-reactive protein precursorP02741ratio: 7.858656753
A1914 CTNA2_HUMANCTNNA2, CAPRCatenin alpha-2P26232ratio: 5.288749915
A1682 CTRC_HUMANCTRC, CLCRCaldecrin precursorQ99895ratio: 8.70038926
A931B CYC_HUMANCYCS, CYCCytochrome CP99999ratio: 2.318023168
B4287 DERL2_HUMANDERL2, DER2, FLANADerlin-2Q9GZP9ratio: 0.463084163
A6304 DGLA_HUMANDAGLA, NSDDRSn1-specific diacylglycerol lipase alphaQ9Y4D2ratio: 3.108208443
B4547 DOXA2_HUMANDUOXA2Dual oxidase maturation factor 2Q1HG44ratio: 2.446740191
A4757 DSG3_HUMANDSG3, CDHF6Desmoglein 3 precursorP32926ratio: 0.411759995
A6379 DUOX2_HUMANDUOX2, LNOX2, THOX2Dual oxidase 2 precursorQ9NRD8ratio: 2.50866968
A6406 ECH1_HUMANECH1Delta(3,5)-delta(2,4)-dienoyl-CoA isomerase, mitochondrial precursorQ13011ratio: 2.302120652
A318D ECHD3_HUMANECHDC3, PP1494, PP8332Enoyl coenzyme A hydratase domain containing 3Q96DC8ratio: 0.447181499
A6408 ECHM_HUMANECHS1Enoyl-CoA hydratase, mitochondrial precursorP30084ratio: 2.382632861
A6431 ENTP2_HUMANENTPD2, CD39L1Ectonucleoside triphosphate diphosphohydrolase 2Q9Y5L3ratio: 2.087712734
A6436 ERAP1_HUMANERAP1, APPILS, ARTS1Endoplasmic reticulum aminopeptidase 1Q9NZ08ratio: 2.060166481
A2012 ERG24_HUMANTM7SF2, ANG1Delta(14)-sterol reductaseO76062ratio: 0.430534146
A6449 ERO1A_HUMANERO1L, UNQ434/PRO865, ERO1-LERO1-like protein alphaQ96HE7ratio: 2.05614807
A335D ES1_HUMANHES1, KNPIES1 protein homolog, mitochondrial precursorP30042ratio: 2.40621618
A6459 EST3_HUMANCES3, UNQ869/PRO1887, UNQ869Carboxylesterase 3Q6UWW8ratio: 2.501995153
A4795 EVPL_HUMANEVPLEnvoplakinQ92817ratio: 2.485808577
A1500 FA10_HUMANF10Coagulation factor X precursorP00742ratio: 2.607546086
A458B FA73B_HUMANFAM73BFamily with sequence similarity 73, member BQ7L4E1ratio: 0.498713234
A4806 FBN1_HUMANFBN1, FBNFibrillin-1P35555ratio: 0.379086731
A9299 FCG3B_HUMANFCGR3B, CD16B, FCG3Low affinity immunoglobulin gamma Fc region receptor III-B precursorO75015ratio: 0.343144449
A1267 FGR_HUMANFGR, SRC2, c-fgrProto-oncogene tyrosine-protein kinase FGRP09769ratio: 0.496131344
A0848 FHIT_HUMANFHITBis(5'-adenosyl)-triphosphataseP49789ratio: 2.331573066
A481D GATC_HUMANGATC, 15E1.2GATC-like proteinO43716ratio: 2.162962795
A456A GCFC2_HUMANGCFC2, GCF, TCF9GC-rich sequence DNA-binding factorP16383ratio: 0.404525811
A6576 GCNT3_HUMANGCNT3, C2/4GNTBeta-1,6-N-acetylglucosaminyltransferaseO95395ratio: 2.851507805
A6617 GLYL1_HUMANGLYATL1, GNAT, GATF-CGlycine-N-acyltransferase-like protein 1Q969I3ratio: 3.285187588
A512D GRAM3_HUMANGRAMD3, NS3TP2GRAM domain-containing protein 3Q96HH9ratio: 0.491439913
A479A H2A1B_HUMANHIST1H2AB, HIST1H2AE, H2AFMHistone H2A.aP04908ratio: 0.481484771
A1462 HAT1_HUMANHAT1, KAT1Histone acetyltransferase 1O14929ratio: 2.791596637
A4131 HAUS6_HUMANFAM29A, HAUS6, DGT6Haus augmin-like complex subunit 6Q7Z4H7ratio: 3.190409856
A532D HEBP2_HUMANHEBP2, SOULHeme-binding protein 2Q9Y5Z4ratio: 2.006698182
B7090 HEMK1_HUMANHEMK1, HEMKHEMK methyltransferase family member 1Q9Y5R4ratio: 2.333670637
A6725 HIBCH_HUMANHIBCH3-Hydroxyisobutyryl-coenzyme A hydrolase, mitochondrialQ6NVY1ratio: 2.161067139
A4332 HS74L_HUMANHSPA4L, APG1, OSP94Osmotic stress protein 94O95757ratio: 2.837083503
A4338 HSC20_HUMANHSCB, RP3-366L4.2, DNAJC20Iron-sulfur cluster co-chaperone protein HSCB, mitochondrial precursorQ8IWL3ratio: 3.613482376
A4344 HSP7E_HUMANHSPA14, HSP60, HSP70L1Heat shock 70 kDa protein 14Q0VDF9ratio: 0.499620567
A1424 IGHA2_HUMANIGHA2, IGH@Ig alpha-2 chainP01877ratio: 2.086766089
A598A IMP3_HUMANMRPS4, IMP3, BRMS2U3 small nucleolar ribonucleoprotein protein IMP3Q9NV31ratio: 0.461362858
A8427 ISK1_HUMANSPINK1, PSTIPancreatic secretory trypsin inhibitor precursorP00995ratio: 4.59782289
A3786 K1C13_HUMANGUCA1B, KRT13Keratin, type I cytoskeletal 13P13646ratio: 2.083520141
A1063 KGP1_HUMANPRKG1, PRKG1B, PRKGR1AcGMP-dependent protein kinase 1, alpha isozymeQ13976ratio: 0.303302757
A063C KIF1B_HUMANKIF1B, KIF1Bbeta, M7Kinesin-like protein KIF1BO60333ratio: 3.300675116
A060F KIME_HUMANMVKMevalonate kinaseQ03426ratio: 0.341409185
A0309 KPCD3_HUMANPRKD3, EPK2, PRKCNSerine/threonine-protein kinase D3O94806ratio: 0.321935138
A6888 LDHD_HUMANLDHDD-lactate dehydrogenase, mitochondrialQ86WU2ratio: 2.002419363
A586E LIMK2_HUMANLIMK2, LIMK-2, LIMK2BLIM domain kinase 2P53671ratio: 0.454574148
A9384 LIRB2_HUMANLILRB2, ILT4, LIR2Leukocyte immunoglobulin-like receptor subfamily B member 2 precursorQ8N423ratio: 0.452402236
A674D LRC40_HUMANLRRC40Leucine-rich repeat-containing protein 40Q9H9A6ratio: 2.879076163
A1971 MAAI_HUMANGSTZ1, MAAIGlutathione S-transferase zeta 1O43708ratio: 2.20013188
A104C MCFD2_HUMANMCFD2, SDNSFNeural stem cell derived neuronal survival proteinQ8NI22ratio: 2.551870186
A4970 MFAP2_HUMANMFAP2, MAGP1Microfibrillar-associated protein 2 precursorP55001ratio: 0.45573425
A535B MFS11_HUMANMFSD11, ETUNC93-like protein MFSD11O43934ratio: 0.454781607
B9681 MFSD9_HUMANMFSD9Major facilitator superfamily domain-containing protein 9Q8NBP5ratio: 2.327167157
B9684 MGAL1_HUMAN Putative maltase-glucoamylase-like protein FLJ16351Q6ZN80ratio: 2.053132323
B9687 MGAT3_HUMANMGAT3, GGNT3Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferaseQ09327ratio: 2.242131296
B9778 MKRN2_HUMANMKRN2, RNF62, HSPC070Makorin 2Q9H000ratio: 0.216652935
A7040 MMAB_HUMANMMABCob(I)alamin adenosyltransferase, mitochondrial precursorQ96EY8ratio: 2.218156138
A1529 MMP2_HUMANMMP2, CLG4A72 kDa type IV collagenase precursorP08253ratio: 0.393776905
A1654 MMP7_HUMANMMP7, MPSL1, PUMP1Matrilysin precursorP09237ratio: 0.165160043
A7051 MMSA_HUMANMMSADHA, ALDH6A1, MMSDHMethylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial precursorQ02252ratio: 2.208073359
A7053 MOCS3_HUMANMOCS3, UBA4Molybdenum cofactor synthesis protein 3O95396ratio: 0.316293602
A0874 MYD88_HUMANMYD88Myeloid differentiation primary response protein MyD88Q99836ratio: 0.399832029
A9731 NFU1_HUMANNFU1, HIRIP5, CGI-33HIRA-interacting protein 5Q9UMS0ratio: 2.149442498
A795A NPDC1_HUMANNPDC1Neural proliferation differentiation and control protein-1 precursorQ9NQX5ratio: 3.412105981
A7190 NT5D3_HUMANNT5DC3, GNN, TU12B1-TY5'-nucleotidase domain-containing protein 3Q86UY8ratio: 2.231772679
A7195 NU2M_HUMANND2, NADH2, MT-ND2NADH-ubiquinone oxidoreductase chain 2P03891ratio: 2.350254838
A8907 NUB1_HUMANNUB1, NYREN18NEDD8 ultimate buster-1Q9Y5A7ratio: 0.272582024
A431D NXPE1_HUMANNXPE1, FAM55AProtein FAM55AQ8N323ratio: 2.982501721
A7223 OAT_HUMANOATOrnithine aminotransferase, mitochondrial precursorP04181ratio: 2.062018988
A3687 ODPB_HUMANPDHB, PHE1BPyruvate dehydrogenase E1 component beta subunit, mitochondrial precursorP11177ratio: 2.005898194
A7236 ORN_HUMANREXO2, SFN, SMFNOligoribonuclease, mitochondrial precursorQ9Y3B8ratio: 2.004697526
A0458 P53_HUMANTP53, p53, P53Cellular tumor antigen p53P04637ratio: 0.133262267
A0106 PA24A_HUMANPLA2G4A, CPLA2, PLA2G4Cytosolic phospholipase A2P47712ratio: 3.385345773
A823A PABP2_HUMANPABPN1, PAB2, PABP2Poly(A) binding protein IIQ86U42ratio: 2.957895713
A0693 PACN3_HUMANPACSIN3Protein kinase C and casein kinase substrate in neurons protein 3Q9UKS6ratio: 0.266552541
BB864 PAR10_HUMANPARP10Poly [ADP]-ribose polymerase 10Q53GL7ratio: 0.244245053
A3602 PCCB_HUMANPCCBPropionyl-CoA carboxylase beta chain, mitochondrial precursorP05166ratio: 2.041789305
A032A PDCD5_HUMANPDCD5, TFAR19Programmed cell death protein 5O14737ratio: 4.329474962
A035A PDCL3_HUMANPDCL3, VIAF1, PhLP2APhosducin-like protein 3Q9H2J4ratio: 2.81594522
A8920 PHAG1_HUMANPAG1, CBP, PAGPhosphoprotein associated with GEMsQ9NWQ8ratio: 2.202013219
A5434 PLIN2_HUMANADFP, PLIN2AdipophilinQ99541ratio: 0.485459197
A5090 POSTN_HUMANPOSTN, OSF2, OSF-2Periostin, osteoblast specific factorQ15063ratio: 0.425341671
A0980 PPR3D_HUMANPPP1R3D, PPP1R6Protein phosphatase 1, regulatory subunit 3DO95685ratio: 0.346699906
A579B PX11A_HUMANPEX11A, PEX11Peroxisomal membrane protein 11AO75192ratio: 0.488501689
A3708 RDHE2_HUMANSDR16C5, RDHE2, RDH-E2Epidermal retinol dehydrogenase 2Q8N3Y7ratio: 4.330436826
A348C REEP6_HUMANREEP6, DP1L1Receptor accessory protein 6Q96HR9ratio: 3.177401452
A5448 REG1A_HUMANREG1A, PSPS, PSPS1Lithostathine 1 alpha precursorP05451ratio: 3.076332822
A1076 RGAP1_HUMANRACGAP1, MGCRACGAPGTPase activating protein RACGAP1Q9H0H5ratio: 0.245973624
BE047 RPC3_HUMANPOLR3C, RPC62RNA polymerase III subunit, DNA directed, 62kDQ9BUI4ratio: 2.413616949
A597B SE6L2_HUMANSEZ6L2, PSK, UNQ1903/PRO4349Seizure 6-like protein 2Q6UXD5ratio: 2.103760892
A7810 SIA4A_HUMANST3GAL1, SIAT4, SIAT4ACMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferaseQ11201ratio: 2.096725451
BF071 SL9A7_HUMANSLC9A7, NHE7, SLC9A6Nonselective sodium potassium/proton exchangerQ96T83ratio: 3.193192519
A4220 SMC4_HUMANSMC4L1, SMC4, CAPCStructural maintenance of chromosomes protein 4Q9NTJ3ratio: 0.487194147
A5132 SMOC2_HUMANSMOC2, SMAP2, MSTP117SPARC related modular calcium-binding protein 2 precursorQ9H3U7ratio: 3.836077462
A7836 SMS1_HUMANTMEM23, SGMS1, MOBSphingomyelin synthase 1Q86VZ5ratio: 3.381286669
BF272 SNX21_HUMANSNX21, SNXL, PP3993Sorting nexin 21Q969T3ratio: 0.286320368
A8500 SPB3_HUMANSCCA1, SERPINB3, SCCASquamous cell carcinoma antigen 1P29508ratio: 2.095353001
BF548 SPX3_HUMANSLC37A3, SPX3Solute carrier family 37 (glycerol-3-phosphate transporter), member 3Q8NCC5ratio: 2.056181654
BF761 STMN3_HUMANSTMN3, SCLIPStathmin 3Q9NZ72ratio: 0.232020654
A2118 STRN4_HUMANSTRN4, ZINStriatin 4Q9NRL3ratio: 2.229592608
A3621 SUCB1_HUMANSUCLA2Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial precursorQ9P2R7ratio: 2.126625368
A7900 SUCB2_HUMANSUCLG2Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial precursorQ96I99ratio: 2.041830101
A629B T184A_HUMANTMEM184ATransmembrane protein 184AQ6ZMB5ratio: 2.898218791
A599C THIOM_HUMANTXN2, TRX2Thioredoxin, mitochondrial precursorQ99757ratio: 2.284051502
A7984 THTR_HUMANTSTThiosulfate sulfurtransferaseQ16762ratio: 2.262643609
A635B TIG1_HUMANRARRES1, TIG1Retinoic acid receptor responder protein 1P49788ratio: 2.685854836
A1496 TPA_HUMANPLAT, tPATissue-type plasminogen activator precursorP00750ratio: 0.494386086
BH044 TR10B_HUMANTNFRSF10B, DR5, KILLERTumor necrosis factor receptor superfamily member 10B precursorO14763ratio: 0.355641019
A131B TRI27_HUMANTRIM27, RFP, RNF76Tripartite motif-containing protein 27P14373ratio: 2.059446289
A1646 TRI29_HUMANTRIM29, ATDCTripartite motif-containing protein 29Q14134ratio: 2.692297854
A124F TRI72_HUMANTRIM72, MG53Tripartite motif-containing protein 72Q6ZMU5ratio: 11.05341492
BH312 TT39A_HUMANTTC39A, DEME-6Tetratricopeptide repeat protein 39AQ5SRH9ratio: 3.154704262
A8065 TTK_HUMANTTK, MPS1, MPS1L1Dual specificity protein kinase TTKP33981ratio: 3.645069294
A8104 UBE2Z_HUMANUBE2Z, HOYS7Ubiquitin-conjugating enzyme E2Q9H832ratio: 2.01654479
A8157 UD2B7_HUMANUGT2B7, UGTB2B9UDP-glucuronosyltransferase 2B7 precursor, microsomalP16662ratio: 0.384511892
BH777 VANG2_HUMANVANGL2, STB1Vang-like protein 2Q9ULK5ratio: 0.391333474
A2164 VGF_HUMANVGFNeurosecretory protein VGF precursorO15240ratio: 8.630394627
A746B VSI10_HUMANVSIG10IG-like domain-containing protein FLJ20674Q8N0Z9ratio: 3.056073361
BI159 XPO6_HUMANXPO6, RANBP20Exportin-6Q96QU8ratio: 2.658770654
A8206 XRN1_HUMANXRN1, 42979DNA strand-exchange protein SEP1Q8IZH2ratio: 0.304945741
A2723 ZN471_HUMANZNF471, ERP1Zinc finger protein 471Q9BX82ratio: 7.257405001
A1821 1A25_HUMANHLA-A, HLA-A*24, HLAHLA class I histocompatibility antigen, A-2 alpha chain precursorP30453ratio: 11.71611433
A1821 1A25_HUMANHLA-A, HLA-A*24, HLAHLA class I histocompatibility antigen, A-2 alpha chain precursorP16188ratio: 6.031007062
A1823 1B73_HUMANHLA-B, HLA-B*40, HLA-B*13HLA class I histocompatibility antigen, B-35 alpha chain precursorP30461ratio: 4.398293594
A1824 1C05_HUMANHLA-C, MHC class I, HLA-CwMajor histocompatibility complex, class I, CP30504ratio: 43.41494206
A8599 DRB5_HUMANHLA-DRbeta, HLA-DRB6*01, HLA-DRB1HLA class II histocompatibility antigen, DRB1-4 beta chain precursorP01911ratio: 0.239052719
A8599 DRB5_HUMANHLA-DRbeta, HLA-DRB6*01, HLA-DRB1HLA class II histocompatibility antigen, DRB1-4 beta chain precursorQ30154ratio: 0.455788371
A8054 TRYB1_HUMANTPSAB1, TPS1, TPS2Tryptase alpha/beta-1P15157ratio: 0.467324196
A0631 C1QBP_HUMANC1QBP, GC1QBP, HABP1Complement component 1, Q subcomponent binding protein, mitochondrial precursorQ07021ratio: 2.121869508
A071F EKI1_HUMANETNK1, EKI1, EKIEthanolamine kinase 1Q9HBU6ratio: 3.371345114
A0883 IRS2_HUMANIRS2, irs-2, IRS-2Insulin receptor substrate-2Q9Y4H2ratio: 0.208409469
A7650 QPCT_HUMANQPCTGlutaminyl-peptide cyclotransferase precursorQ16769ratio: 2.595448509
A1125 SMAD3_HUMANSMAD3, MADH3, MAD3Mothers against decapentaplegic homolog 3P84022ratio: 0.388829872
A9753 SPD2B_HUMANSH3PXD2B, FAD49, TKS4SH3 and PX domain-containing protein 2BA1X283ratio: 0.415536547

Compile date 10-20-2017© .