MoCadb-logoMoCadb - Study ID Exp24687888b

PubMed ID24687888
AuthorsKume H(1), Muraoka S(1), Kuga T(1), Adachi J(1), Narumi R(1), Watanabe S(1), Kuwano M(1), Kodera Y(2), Matsushita K(3), Fukuoka J(4), Masuda T(5), Ishihama Y(6), Matsubara H(7), Nomura F(3), Tomonaga T(8).
TitleDiscovery of colorectal cancer biomarker candidates by membrane proteomic analysis and subsequent verification using selected reaction monitoring (SRM) and tissue microarray (TMA) analysis.
JournalMol Cell Proteomics. 2014 Jun;13(6):1471-84.
AbstractRecent advances in quantitative proteomic technology have enabled the large-scale validation of biomarkers. We here performed a quantitative proteomic analysis of membrane fractions from colorectal cancer tissue to discover biomarker candidates, and then extensively validated the candidate proteins identified. A total of 5566 proteins were identified in six tissue samples, each of which was obtained from polyps and cancer with and without metastasis. GO cellular component analysis predicted that 3087 of these proteins were membrane proteins, whereas TMHMM algorithm predicted that 1567 proteins had a transmembrane domain. Differences were observed in the expression of 159 membrane proteins and 55 extracellular proteins between polyps and cancer without metastasis, while the expression of 32 membrane proteins and 17 extracellular proteins differed between cancer with and without metastasis. A total of 105 of these biomarker candidates were quantitated using selected (or multiple) reaction monitoring (SRM/MRM) with stable synthetic isotope-labeled peptides as an internal control. The results obtained revealed differences in the expression of 69 of these proteins, and this was subsequently verified in an independent set of patient samples (polyps (n = 10), cancer without metastasis (n = 10), cancer with metastasis (n = 10)). Significant differences were observed in the expression of 44 of these proteins, including ITGA5, GPRC5A, PDGFRB, and TFRC, which have already been shown to be overexpressed in colorectal cancer, as well as proteins with unknown function, such as C8orf55. The expression of C8orf55 was also shown to be high not only in colorectal cancer, but also in several cancer tissues using a multicancer tissue microarray, which included 1150 cores from 14 cancer tissues. This is the largest verification study of biomarker candidate membrane proteins to date; our methods for biomarker discovery and subsequent validation using SRM/MRM will contribute to the identification of useful biomarker candidates for various cancers. Data are available via ProteomeXchange with identifier PXD000851.

Sample characteristics

SpeciesTissue / SourceCompartmentDiseaseNDetection methodSample
Homo sapienspolyp_and_tumorMembrane FractionsCRC metastasis32LC-MS/MSDem4687888a, Dem4687888c

Sample description and preparation

N (case)16
N (control)16
Disease (case)CRC metastasis
Disease (control)colorectal polyps
Preparation specific methodiTRAQ-labelling
Digestin-solution digestion, Trypsin
SeparationSCX column
Storage condition-80C

Sample analysis

Software analysis toolProteome Discoverer ver.1.3
Software thresholdP<0.1, fold change>2.0

Molecule list

Molecule IDextExternal IDGeneNameSource accRegulation (case/control)Scores
A5621 5NTD_HUMANNT5E, NT5, NTE5'-nucleotidase precursorP21589ratio: 2.387215277
A780B ABCD1_HUMANALD, ABCD1, ALDPAdrenoleukodystrophy proteinP33897ratio: 2.070040869
A5700 ACSS3_HUMANACSS3Acyl-CoA synthetase short-chain family member 3 mitochondrialQ9H6R3ratio: 0.484977558
A5708 ADA_HUMANADA, ADA1Adenosine deaminaseP00813ratio: 2.212493115
A5724 ADEC1_HUMANADAMDEC1ADAM-like, Decysin 1O15204ratio: 0.306858791
A5728 ADH1G_HUMANADH3, ADH1CAlcohol dehydrogenase 1CP00326ratio: 0.278014714
A5751 AK1BA_HUMANAKR1B10, AKR1B11Aldo-keto reductase family 1 member B10O60218ratio: 0.281858797
A0143 AKAP5_HUMANAKAP5, AKAP79A-kinase anchor protein 5P24588ratio: 0.481026237
A3585 AL1A1_HUMANALDH1A1, ALDC, ALDH1Aldehyde dehydrogenase 1A1P00352ratio: 0.324372882
A4421 ANO7_HUMANANO7, NGEP, PCANAP5Anoctamin-7Q6IWH7ratio: 0.354591985
A4570 ANTR1_HUMANANTXR1, ATR, TEM8Anthrax toxin receptor 1 precursorQ9H6X2ratio: 2.08797379
A4574 ANX13_HUMANANXA13, ANX13Annexin A13P27216ratio: 0.4597361
A1809 APOC2_HUMANAPOC2, APC2Apolipoprotein C-II precursorP02655ratio: 2.829857974
A560E AREG_HUMANAREG, SDGF, AREGBAmphiregulin precursorP15514ratio: 2.464160007
A9786 B2L14_HUMANBCL2L14, BCLGApoptosis facilitator BCL-2-like protein 14Q9BZR8ratio: 2.680122524
B1334 B3GN6_HUMANB3GNT6, BETA3GNT6, B3Gn-T6Beta-1,3-N-acetylglucosaminyltransferase 6Q6ZMB0ratio: 0.286231271
A5910 B4GN2_HUMANB4GALNT2, GALGT2Beta-1,4 N-acetylgalactosaminyltransferase 2Q8NHY0ratio: 0.235832449
A4273 BAG2_HUMANBAG2BAG-family molecular chaperone regulator-2O95816ratio: 2.532694534
A2225 BRDT_HUMANBRDTBromodomain testis-specific proteinQ58F21ratio: 3.354696593
A1594 C4BPA_HUMANC4BPA, C4BPC4b-binding protein alpha chain precursorP04003ratio: 2.392530506
B1938 CAN9_HUMANCAPN9, NCL4Calpain 9O14815ratio: 0.367960222
A8697 CAR10_HUMANCARD10, CARMA3Caspase recruitment domain protein 10Q9BWT7ratio: 0.452835035
A010D CCD93_HUMANCCDC93Coiled-coil domain-containing protein 93Q567U6ratio: 0.455935399
A9817 CCL20_HUMANCCL20, LARC, MIP3ASmall inducible cytokine A20 precursorP78556ratio: 2.047794639
B2493 CDKA1_HUMANCDK2AP1, CDKAP1, DOC1Cyclin-dependent kinase 2-associated protein 1O14519ratio: 0.45111256
A4665 CEAM5_HUMANCEACAM5, CEACarcinoembryonic antigen-related cell adhesion molecule 5P06731ratio: 2.567047205
A4666 CEAM6_HUMANCEA, CEACAM6, NCACarcinoembryonic antigen-related cell adhesion molecule 6 precursorP40199ratio: 3.119350926
A1680 CEL3A_HUMANELA3A, CELA3A, ELA3Elastase IIIA precursorP09093ratio: 3.510536892
A2529 CELF2_HUMANCELF2, CUGBP2, BRUNOL3Paraneoplastic Encephalomyelitis antigen family proteinO95319ratio: 2.514264279
A501B CERS6_HUMANLASS6, CERS6Ceramide synthase 6Q6ZMG9ratio: 2.024117632
A291A CHM1A_HUMANCHMP1A, CHMP1, PCOLN3Chromatin modifying protein 1AQ9HD42ratio: 2.11549092
A4090 CHM1B_HUMANCHMP1B, CHMP1.5Charged multivesicular body protein 1BQ7LBR1ratio: 2.020658315
A868B CHM2B_HUMANCHMP2B, CGI-84Charged multivesicular body protein 2BQ9UQN3ratio: 2.594057112
A869B CHM4A_HUMANCHMP4A, Shax2, HSPC134Charged multivesicular body protein 4aQ9BY43ratio: 2.268922066
A870B CHM4B_HUMANCHMP4B, SHAX1, SNF7-2Charged multivesicular body protein 4BQ9H444ratio: 2.895047027
A871B CHM4C_HUMANCHMP4C, SHAX3, Shax3SNF7-3Q96CF2ratio: 2.2152195
A873B CHMP5_HUMANCHMP5, SNF7DC2, CGI-34Charged multivesicular body protein 5Q9NZZ3ratio: 2.08686136
B2807 CHMP7_HUMANCHMP7Charged multivesicular body protein 7Q8WUX9ratio: 2.743571943
A6054 CHPF2_HUMANCHPF2, CSGlcA-T, CHSY3Chondroitin sulfate glucuronyltransferaseQ9P2E5ratio: 2.033425218
A6057 CHSS2_HUMANCHPF, CSS2, UNQ651/PRO1281Chondroitin sulfate synthase 2Q8IZ52ratio: 2.229377699
B2985 CKLF3_HUMANCMTM3, CKLFSF3CKLF-like MARVEL transmembrane domain-containing protein 3Q96MX0ratio: 2.8751619
A878B CLCA1_HUMANCLCA1, CACC1, HCLCA1Chloride channel, calcium activated, family member 1 precursorA8K7I4ratio: 0.120946943
A1276 CLUS_HUMANCLU, APOJ, CLIClusterin precursorP10909ratio: 2.091609257
A9841 CMGA_HUMANCHGAChromogranin A precursorP10645ratio: 5.588123692
A8718 CNPY3_HUMANCNPY3, CTG4A, ERDA5Protein Canopy homolog 3 precursorQ9BT09ratio: 2.34495192
A1616 CO5_HUMANC5, CPAMD4Complement C5 precursorP01031ratio: 2.886725212
A1623 CO6_HUMANC6Complement component C6P13671ratio: 2.779843194
A1422 CO6A2_HUMANCOL6A2Collagen alpha 2(VI) chain precursorP12110ratio: 0.489372773
A1624 CO7_HUMANC7Complement component C7 precursorP10643ratio: 3.888097264
A1627 CO8G_HUMANC8GComplement component C8 gamma chain precursorP07360ratio: 2.191509246
A1628 CO9_HUMANC9Complement component C9 precursorP02748ratio: 2.630675216
A4099 COQ4_HUMANCOQ4, CGI-92Ubiquinone biosynthesis protein COQ4 homolog, mitochondrialQ9Y3A0ratio: 2.491573237
A6169 CP39A_HUMANCYP39A1Cytochrome P450, family 39, subfamily A, polypeptide 1Q9NYL5ratio: 2.015327386
A6212 CRP_HUMANCRP, PTX1C-reactive protein precursorP02741ratio: 7.52715806
A1914 CTNA2_HUMANCTNNA2, CAPRCatenin alpha-2P26232ratio: 3.65637597
A1682 CTRC_HUMANCTRC, CLCRCaldecrin precursorQ99895ratio: 5.984462612
B3966 CXB2_HUMANGJB2Gap junction beta-2 proteinP29033ratio: 2.464806503
A1614 DAF_HUMANCD55, DAF, CRComplement decay-accelerating factor precursorP08174ratio: 2.130420596
A9867 DEF1_HUMANEm:AF200455.10, DEFA1, Em:AF200455.12Neutrophil defensin 1 precursorP59665ratio: 0.229724861
B4254 DEF5_HUMANDEFA5, DEF5Defensin 5 precursorQ01523ratio: 0.080280521
A9870 DEF6_HUMANDEFA6, DEF6Defensin 6 precursorQ01524ratio: 0.121927644
A4749 DERM_HUMANDPTDermatopontin precursorQ07507ratio: 0.388612179
A6312 DHC24_HUMANDHCR2424-dehydrocholesterol reductase precursorQ15392ratio: 2.222577081
A2013 DHCR7_HUMANDHCR7, D7SR7-dehydrocholesterol reductaseQ9UBM7ratio: 2.097780379
A4297 DJC15_HUMANDNAJC15, DNAJD1, GIG22DNAJ homolog subfamily C member 15Q9Y5T4ratio: 2.068685309
A4305 DNJB2_HUMANDNAJB2, HSJ1, HSPF3DnaJ homolog subfamily B member 2P25686ratio: 3.014830027
A6356 DPEP1_HUMANDPEP1, MDP, RDPMicrosomal dipeptidase precursorP16444ratio: 3.019307253
A0095 DYN1_HUMANDNM1, DNMDynamin-1Q05193ratio: 3.106935186
B4957 ELOV5_HUMANELOVL5, ELOVL2, PRO0530Elongation of very long chain fatty acids protein 5Q9NYP7ratio: 2.694273608
A2472 ENPP6_HUMANENPP6, UNQ1889/PRO4334, UNQ1889Ectonucleotide pyrophosphatase/phosphodiesterase 6Q6UWR7ratio: 0.338275169
A6431 ENTP2_HUMANENTPD2, CD39L1Ectonucleoside triphosphate diphosphohydrolase 2Q9Y5L3ratio: 2.834656841
B5093 EPHX4_HUMANEPHX4, ABHD7, EPHXRPEpoxide hydrolase 4Q8IUS5ratio: 2.586599614
A6449 ERO1A_HUMANERO1L, UNQ434/PRO865, ERO1-LERO1-like protein alphaQ96HE7ratio: 2.388937078
A438B F173A_HUMANFAM173A, RJD7Similar to FBan0003337Q9BQD7ratio: 2.105678704
A1500 FA10_HUMANF10Coagulation factor X precursorP00742ratio: 4.441230934
A1540 FA9_HUMANF9, FIX, F9p22Coagulation factor IX precursorP00740ratio: 2.584461737
A451D FAKD3_HUMANFASTKD3, HSPC091FAST kinase domain-containing protein 3Q14CZ7ratio: 2.048061808
A2240 FBXL4_HUMANFBXL4, FBL4, FBL5F-box/LRR-repeat protein 4Q9UKA2ratio: 2.088446273
A9713 FCGBP_HUMANFCGBPIgG Fc binding proteinQ9Y6R7ratio: 0.252264346
A2265 FCN1_HUMANFCN1, FCNMFicolin 1 precursorO00602ratio: 0.388585869
A2270 FGL2_HUMANFGL2Fibroleukin precursorQ14314ratio: 0.29876385
A6514 FMO3_HUMANFMO3Dimethylaniline monooxygenase [N-oxide forming] 3P31513ratio: 0.2189087
A463B FR1L6_HUMANFER1L6FER-1-like protein 6Q2WGJ9ratio: 0.389460906
A6568 GALT8_HUMANGALNT8UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8Q9NY28ratio: 0.494107496
A0061 GBG4_HUMANGNG4, GNGT4Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-4 subunitP50150ratio: 2.557509287
A6576 GCNT3_HUMANGCNT3, C2/4GNTBeta-1,6-N-acetylglucosaminyltransferaseO95395ratio: 2.326826604
A3576 GDAP1_HUMANGDAP1Ganglioside-induced differentiation-associated protein 1Q8TB36ratio: 2.097093312
B6347 GEMI8_HUMANGEMIN8, FAM51A1GEM-associated protein 8Q9NWZ8ratio: 2.437732003
A001C GLE1_HUMANGLE1, GLE1LNucleoporin GLE1Q53GS7ratio: 2.356801464
A6617 GLYL1_HUMANGLYATL1, GNAT, GATF-CGlycine-N-acyltransferase-like protein 1Q969I3ratio: 7.653806112
A4843 GOGA1_HUMANGOLGA1Golgin subfamily A member 1Q92805ratio: 2.093116515
A512D GRAM3_HUMANGRAMD3, NS3TP2GRAM domain-containing protein 3Q96HH9ratio: 2.03775829
A1306 GTR1_HUMANSLC2A1, GLUT1Solute carrier family 2, facilitated glucose transporter, member 1P11166ratio: 2.110764109
A6677 GXLT1_HUMANGXYLT1, GLT8D3Glucoside xylosyltransferase 1Q4G148ratio: 2.034331968
A4131 HAUS6_HUMANFAM29A, HAUS6, DGT6Haus augmin-like complex subunit 6Q7Z4H7ratio: 2.306179652
A6695 HDAC2_HUMANHDAC2Histone deacetylase 2Q92769ratio: 2.418164085
A8414 HEP2_HUMANSERPIND1, HCF2Serpin peptidase inhibitor, clade D (heparin cofactor), member 1P05546ratio: 2.126610508
A6730 HKDC1_HUMANHKDC1Putative Hexokinase HKDC1Q2TB90ratio: 4.263668919
A0486 HMOX1_HUMANHMOX1, HO, HO1Heme oxygenase 1P09601ratio: 0.48180593
A3792 HNRPM_HUMANHNRNPM, HNRPM, NAGR1Heterogeneous nuclear ribonucleoprotein MP52272ratio: 2.103760863
A4338 HSC20_HUMANHSCB, RP3-366L4.2, DNAJC20Iron-sulfur cluster co-chaperone protein HSCB, mitochondrial precursorQ8IWL3ratio: 2.321783928
A2006 HSP72_HUMANHSPA2Heat shock-related 70 kDa protein 2P54652ratio: 0.464758209
A4856 HSPB1_HUMANHSPB1, HSP27, HSP28Heat shock protein beta-1P04792ratio: 2.829296239
A548D IBP2_HUMANIGFBP2, BP2, IBP2Insulin-like growth factor-binding protein 2P18065ratio: 0.418044056
A482B IFM3_HUMANIFITM3Interferon-induced transmembrane protein 3Q01628ratio: 2.181831954
A0873 IRAK1_HUMANIRAK1, IRAKInterleukin-1 receptor-associated kinase 1P51617ratio: 2.606491404
A1691 ITA11_HUMANITGA11, MSTP018, MST018Integrin alpha-11 precursorQ9UKX5ratio: 2.004298439
A9965 ITLN1_HUMANITLN1, INTL, ITLNIntelectin 1Q8WWA0ratio: 0.353293786
A6831 KBL_HUMANGCAT, KBL2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial precursorO75600ratio: 0.387379135
A3691 KCRS_HUMANCKMT2Creatine kinase S-type, mitochondrialP17540ratio: 5.765397478
A063C KIF1B_HUMANKIF1B, KIF1Bbeta, M7Kinesin-like protein KIF1BO60333ratio: 2.039586259
A1371 LBR_HUMANLBRLamin B receptorQ14739ratio: 2.056600805
A6904 LITD1_HUMANL1TD1, ECAT11Line-1 type transposase domain-containing protein 1Q5T7N2ratio: 0.258182164
B8951 LMBR1_HUMANLMBR1, DIF14Limb region 1 protein homologQ8WVP7ratio: 2.023473804
A6913 LOX15_HUMANALOX15, LOG15Arachidonate 15-lipoxygenaseP16050ratio: 0.454013598
B8994 LPAR1_HUMANLPAR1, EDG2, LPA1Lysophosphatidic acid receptor 1Q92633ratio: 0.359432871
A9388 LPHN2_HUMANLPHN2, LPHH1, LEC1Latrophilin 2O95490ratio: 0.477781718
A6949 MA1C1_HUMANMAN1C1, pp6318, MAN1A3Mannosyl-oligosaccharide 1,2-alpha-mannosidase ICQ9NR34ratio: 2.565469162
A1567 MADCA_HUMANMADCAM1, MADCAM-1Mucosal addressin cell adhesion molecule-1 precursorQ13477ratio: 0.333799025
A105C MELPH_HUMANMLPH, UNQ8200, SLAC2AMelanophilinQ9BV36ratio: 0.469769914
B9684 MGAL1_HUMAN Putative maltase-glucoamylase-like protein FLJ16351Q6ZN80ratio: 2.151832201
A7024 MGT5A_HUMANMGAT5, GGNT5Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase VQ09328ratio: 2.307049188
A2316 MILK1_HUMANMICALL1, MIRAB13, MICAL-L1Molecule interacting with Rab13Q8N3F8ratio: 0.296613375
B9778 MKRN2_HUMANMKRN2, RNF62, HSPC070Makorin 2Q9H000ratio: 0.453991021
A1653 MMP3_HUMANMMP3, STMY1Stromelysin-1 precursorP08254ratio: 0.101793914
A4978 MPP8_HUMANMPHOSPH8, MPP8, HSMPP8M-phase phosphoprotein 8Q99549ratio: 3.099095144
A140C MRS2_HUMANMRS2, HPT, MRS2LMagnesium transporter MRS2L, mitochondrial precursorQ9HD23ratio: 2.431084001
BA019 MSMO1_HUMANSC4MOL, MSMO1, DESP4C-4 methyl sterol oxidaseQ15800ratio: 2.026366833
A4992 MUC2_HUMANMUC2, mucin, MLPMucin 2 precursorQ02817ratio: 0.343768157
A2615 MUC5B_HUMANMUC5B, MUC5, MG1Mucin-5BQ9HC84ratio: 0.469538212
A1163 NCDN_HUMANNCDNNeurochondrinQ9UBB6ratio: 2.127046978
A191C NDC1_HUMANTMEM48, NDC1Transmembrane protein 48Q9BTX1ratio: 2.036826763
A7195 NU2M_HUMANND2, NADH2, MT-ND2NADH-ubiquinone oxidoreductase chain 2P03891ratio: 2.310647541
A542E OLFL1_HUMANOLFML1, UNQ564/PRO1126, UNQ564Olfactomedin-like protein 1 precursorQ6UWY5ratio: 0.336543612
A5018 OLFM4_HUMANOLFM4, GW112, UNQ362/PRO698Olfactomedin-4Q6UX06ratio: 0.301786939
A9427 OSCAR_HUMANOSCAR, PIGR3Osteoclast-associated immunoglobulin-like receptorQ8IYS5ratio: 0.251303324
A8914 OX2G_HUMANCD200, MOX1, MOX2OX-2 membrane glycoprotein precursorP41217ratio: 4.411729626
A1814 P4HA1_HUMANP4HA1, P4HAProlyl 4-hydroxylase alpha-1 subunit precursorP13674ratio: 2.037994834
A7274 PADI2_HUMANPADI2, PDI2Peptidylarginine deiminase type 2Q9Y2J8ratio: 0.445425629
A784D PALD_HUMANPALD1, PALDPaladinQ9ULE6ratio: 2.312430873
A3883 PALM_HUMANPALMParalemmin-1O75781ratio: 2.104291668
A9437 PAQR4_HUMANPAQR4Progestin and adipoQ receptor family member IVQ8N4S7ratio: 2.250862097
A7306 PBLD_HUMANPBLD, MAWBPPhenazine biosynthesis-like domain-containing proteinP30039ratio: 0.413278833
A5069 PDLI1_HUMANPDLIM1, CLIM1, CLP36PDZ and LIM domain protein 1O00151ratio: 0.496225416
A279C PEX12_HUMANPEX12, PAF3Peroxisome assembly protein 12O00623ratio: 2.076182923
A280C PEX13_HUMANPEX13Peroxisomal membrane protein PEX13Q92968ratio: 2.340320994
A0706 PGFRB_HUMANPDGFRB, CSF1R, PDGFRBeta-type platelet-derived growth factor receptor precursorP09619ratio: 2.010401275
A7416 PLCB_HUMANAGPAT21-acyl-sn-glycerol-3-phosphate acyltransferase betaO15120ratio: 2.047921655
A7419 PLCB4_HUMANPLCB41-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4Q15147ratio: 0.349172306
A7422 PLCD1_HUMANPLCD11-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta 1P51178ratio: 0.374628666
A1468 PLMN_HUMANPLGPlasminogen precursorP00747ratio: 2.12336752
A7436 PLPL4_HUMANPNPLA4, DXS1283E, GS2Patatin-like phospholipase domain-containing protein 4P41247ratio: 2.064063342
A8939 PODN_HUMANPODN, SLRR5A, UNQ293/PRO332Podocan precursorQ7Z5L7ratio: 0.47094674
A7473 PPB1_HUMANALPP, PLAPAlkaline phosphatase, placental type 1 precursorP05187ratio: 8.078032012
A634D PPR21_HUMANKLRAQ1, PPP1R21, CCDC128KLRAQ motif-containing protein 1Q6ZMI0ratio: 0.492783231
A1701 PRG2_HUMANPRG2, MBPEosinophil granule major basic protein precursorP13727ratio: 0.430255224
A7505 PROD_HUMANPRODH, PIG6, POX2Proline oxidase, mitochondrial precursorO43272ratio: 8.029426298
A0917 PTN3_HUMANPTPN3, PTPH1Protein tyrosine phosphatase, non-receptor type 3P26045ratio: 2.250960213
A583B PXMP4_HUMANPXMP4, PMP24Peroxisomal membrane protein 4Q9Y6I8ratio: 2.191711925
BD209 QTRD1_HUMANQTRTD1Queuine tRNA-ribosyltransferase subunit QTRTD1Q9H974ratio: 2.111240729
A9464 RAI3_HUMANGPRC5A, GPCR5A, RAI3Retinoic acid induced 3Q8NFJ5ratio: 3.064724928
A907A RBCC1_HUMANRB1CC1, RBICCRb1-inducible coiled coil protein 1Q8TDY2ratio: 2.271778556
A230E RCN1_HUMANRCN1, RCNReticulocalbin 1 precursorQ15293ratio: 2.009172632
A231E RCN3_HUMANRCN3, UNQ239/PRO272, UNQ239Reticulocalbin 3 precursorQ96D15ratio: 2.261316969
A348C REEP6_HUMANREEP6, DP1L1Receptor accessory protein 6Q96HR9ratio: 3.606292352
A596E REG4_HUMANREG4, GISP, RELPRegenerating gene type IVQ9BYZ8ratio: 0.312061789
A9003 REP15_HUMANREP15RAB15 effector proteinQ6BDI9ratio: 0.248032854
A7747 RPC2_HUMANPOLR3B, RPC2DNA-directed RNA polymerase III subunit RPC2Q9NW08ratio: 0.489270116
BE229 RUND1_HUMANRUNDC1, LP5161RUN domain-containing protein 1Q96C34ratio: 3.737437896
A274E S100P_HUMANS100P, S100ES-100P proteinP25815ratio: 0.346222046
A107A S10AC_HUMANS100A12Protein S100-A12P80511ratio: 3.462462291
A3767 S2533_HUMANSLC25A33Solute carrier family 25 member 33Q9BSK2ratio: 2.002564164
A3768 S2536_HUMANSLC25A36Solute carrier family 25 member 36Q96CQ1ratio: 3.827380596
A3481 S4A10_HUMANSLC4A10, NCBESodium-driven chloride bicarbonate exchangerQ6U841ratio: 0.396830757
BE610 SC5D_HUMANSC5DLLathosterol oxidaseO75845ratio: 2.134433584
A3755 SCMC3_HUMANSLC25A23, APC2, MCSC2Calcium-binding mitochondrial carrier protein SCaMC-3Q9BV35ratio: 2.016864864
A7792 SEPR_HUMANFAPSepraseQ12884ratio: 4.031240913
A0934 SIA4C_HUMANSIAT4C, ST3GAL4, CGS23CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferaseQ11206ratio: 0.48001597
A7812 SIA7A_HUMANST6GALNAC1, SIAT7A, UNQ543/PRO848Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1Q9NSC7ratio: 0.444350179
A0825 SL9A2_HUMANNa? exchanger isoform NHE-2, SLC9A2, NHE2Sodium/hydrogen exchanger 2Q9UBY0ratio: 0.326846701
A0826 SL9A3_HUMANSLC9A3, NHE3Sodium/hydrogen exchanger 3P48764ratio: 0.378299508
BF071 SL9A7_HUMANSLC9A7, NHE7, SLC9A6Nonselective sodium potassium/proton exchangerQ96T83ratio: 3.747439346
A5132 SMOC2_HUMANSMOC2, SMAP2, MSTP117SPARC related modular calcium-binding protein 2 precursorQ9H3U7ratio: 3.398571766
A7836 SMS1_HUMANTMEM23, SGMS1, MOBSphingomyelin synthase 1Q86VZ5ratio: 2.212144161
A1320 SNP29_HUMANSNAP29Synaptosomal-associated protein 29O95721ratio: 2.534564915
A8500 SPB3_HUMANSCCA1, SERPINB3, SCCASquamous cell carcinoma antigen 1P29508ratio: 3.027524641
A8510 SPIT2_HUMANSPINT2, HAI2, KOPSerine protease inhibitor, Kunitz type, 2 precursorO43291ratio: 2.272899688
A7878 ST1B1_HUMANSULT1B1, ST1B2, SULT1B2Thyroid hormone sulfotransferaseO43704ratio: 0.376461399
BF739 STING_HUMANMITA, TMEM173, ERISStimulator of interferon genes proteinQ86WV6ratio: 2.070460523
A7904 SUOX_HUMANSUOXSulfite oxidase, mitochondrial precursorP51687ratio: 0.496167293
A1321 SYNRG_HUMANSYNRG, AP1GBP1, SYNGGamma-synerginQ9UMZ2ratio: 2.215317176
A3905 SYT7_HUMANSYT7, PCANAP7Synaptotagmin-7O43581ratio: 2.186249938
A5210 TFF3_HUMANTFF3, ITF, TFITrefoil factor 3 precursorQ07654ratio: 0.369585339
A9493 TFR1_HUMANTFRCTransferrin receptor protein 1P02786ratio: 2.380316684
A7970 TGM3_HUMANTGM3Protein-glutamine glutamyltransferase E precursorQ08188ratio: 2.013820125
A080D THEM6_HUMANTHEM6, DSCD75UPF0670 protein C8ORF55Q8WUY1ratio: 2.898094804
A4396 THOC4_HUMANALYREF, ALY, BEFTHO complex subunit 4Q86V81ratio: 0.462351115
A1469 THRB_HUMANF2Prothrombin precursorP00734ratio: 2.04542036
BG583 TLCD1_HUMANTLCD1TLC domain-containing protein 1 precursorQ96CP7ratio: 2.214870877
BG676 TM189_HUMANTMEM189, KUATransmembrane protein 189A5PLL7ratio: 2.028984181
BG745 TM45B_HUMANTMEM45BTransmembrane protein 45BQ96B21ratio: 2.067347477
A698B TMCO1_HUMANTMCO1, TMCC4, PNAS-10Transmembrane and coiled-coil domain-containing protein 1Q9UM00ratio: 2.141911977
A0924 TOP2A_HUMANTOP2A, TOP2DNA topoisomerase 2P11388ratio: 2.037004132
BG977 TP4A3_HUMANPTP4A3, PRL3, HPRL-3Protein tyrosine phosphatase type IVA protein 3O75365ratio: 2.737628585
A1496 TPA_HUMANPLAT, tPATissue-type plasminogen activator precursorP00750ratio: 0.421583791
A124F TRI72_HUMANTRIM72, MG53Tripartite motif-containing protein 72Q6ZMU5ratio: 10.05575288
A4530 TRPA1_HUMANTRPA1, ANKTM1Transient receptor potential cation channel subfamily A member 1O75762ratio: 0.384104253
A5605 TSN7_HUMANTSPAN7, TM4SF2, A15Tetraspanin-7P41732ratio: 0.434619863
A5232 TSP2_HUMANTHBS2, TSP2Thrombospondin 2 precursorP35442ratio: 3.263923063
A8065 TTK_HUMANTTK, MPS1, MPS1L1Dual specificity protein kinase TTKP33981ratio: 3.123711556
A733B UBAC2_HUMANPHGDHL1, UBAC2Ubiquitin-associated domain-containing protein 2 precursorQ8NBM4ratio: 2.224940126
BH640 UD110_HUMANUGT1A10, UGT1J, GNT1UDP-glucuronosyltransferase 1-10 precursor, microsomalQ9HAW8ratio: 0.422591508
A8157 UD2B7_HUMANUGT2B7, UGTB2B9UDP-glucuronosyltransferase 2B7 precursor, microsomalP16662ratio: 0.202491517
A8170 UK114_HUMANUK114, HRSP12, PSPRibonuclease UK114P52758ratio: 2.274111315
A2164 VGF_HUMANVGFNeurosecretory protein VGF precursorO15240ratio: 6.232884288
A9763 VMA21_HUMANVMA21, MEAX, XMEAVacuolar ATPase assembly integral membrane protein VMA21Q3ZAQ7ratio: 2.445124597
A1471 VTNC_HUMANVTNVitronectin precursorP04004ratio: 2.995777216
A649E WNT5B_HUMANWNT5BWingless-type MMTV integration site family, member 5B precursorQ9H1J7ratio: 0.344200872
A8223 ZDHC6_HUMANZDHHC6, ZNF376Probable Palmitoyltransferase ZDHHC6Q9H6R6ratio: 2.473219781
A2723 ZN471_HUMANZNF471, ERP1Zinc finger protein 471Q9BX82ratio: 4.165911845
A1821 1A25_HUMANHLA-A, HLA-A*24, HLAHLA class I histocompatibility antigen, A-2 alpha chain precursorP01892ratio: 0.291747327
A1823 1B73_HUMANHLA-B, HLA-B*40, HLA-B*13HLA class I histocompatibility antigen, B-35 alpha chain precursorP30461ratio: 0.327570787
A1823 1B73_HUMANHLA-B, HLA-B*40, HLA-B*13HLA class I histocompatibility antigen, B-35 alpha chain precursorP30481ratio: 0.109745692
A1823 1B73_HUMANHLA-B, HLA-B*40, HLA-B*13HLA class I histocompatibility antigen, B-35 alpha chain precursorP30483ratio: 0.147024573
A1824 1C05_HUMANHLA-C, MHC class I, HLA-CwMajor histocompatibility complex, class I, CP30504ratio: 14.73744552
A8613 DQA1_HUMANHLA-DQA1, HLA-DRA, HLA DQA1HLA class II histocompatibility antigen, DQ(1) alpha chain precursorP01909ratio: 2.706847774
A8599 DRB5_HUMANHLA-DRbeta, HLA-DRB6*01, HLA-DRB1HLA class II histocompatibility antigen, DRB1-4 beta chain precursorP20039ratio: 10.03434495
A8243 HV312_HUMANIGH, HuVH8B VH, scFvIg heavy chain V-III regionP01768ratio: 0.407251527
A8054 TRYB1_HUMANTPSAB1, TPS1, TPS2Tryptase alpha/beta-1P15157ratio: 0.315520008
A5671 ACOD_HUMANSCD, PRO0998Acyl-CoA desaturaseO00767ratio: 5.518243966
A5694 ACSL3_HUMANACSL3, ACS3, FACL3Long-chain-fatty-acid--CoA ligase 3O95573ratio: 2.086247644
A989B FRIL_HUMANFTL, FTLvariantFerritin light chainP02792ratio: 0.464032567
A428C S35F2_HUMANSLC35F2, HSNOV1Solute carrier family 35 member F2Q8IXU6ratio: 2.294902618
BJ936 TM164_HUMANTMEM164Transmembrane protein 164Q5U3C3ratio: 4.508607741

Compile date 10-20-2017© .