MoCadb-logoMoCadb - Molecule ID B0321

geneACVR1, ACVRLK2
nameActivin receptor type 1 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACVR1_HUMANQ04771ENSG0000011517090Hs.470316102576, 135100

Functions and classifications

GOC:activin receptor complex, C:apical part of cell, F:activin binding, F:activin receptor activity, type I, F:ATP binding, F:metal ion binding, F:peptide hormone binding, F:protein homodimerization activity, F:protein serine/threonine kinase activity, F:receptor signaling protein serine/threonine kinase activity, F:SMAD binding, F:transforming growth factor beta binding, F:transforming growth factor beta receptor activity, type I, P:activin receptor signaling pathway, P:acute inflammatory response, P:atrial septum primum morphogenesis, P:BMP signaling pathway, P:cardiac muscle cell fate commitment, P:cellular response to glucocorticoid stimulus, P:determination of left/right symmetry, P:embryonic heart tube morphogenesis, P:endocardial cushion cell fate commitment, P:G1/S transition of mitotic cell cycle, P:gastrulation with mouth forming second, P:germ cell development, P:in utero embryonic development, P:intracellular signal transduction, P:mesoderm formation, P:mitral valve morphogenesis, P:negative regulation of activin receptor signaling pathway, P:negative regulation of extrinsic apoptotic signaling pathway, P:neural crest cell migration, P:pathway-restricted SMAD protein phosphorylation, P:patterning of blood vessels, P:peptidyl-threonine phosphorylation, P:pharyngeal system development, P:positive regulation of bone mineralization, P:positive regulation of determination of dorsal identity, P:positive regulation of osteoblast differentiation, P:positive regulation of pathway-restricted SMAD protein phosphorylation, P:positive regulation of transcription from RNA polymerase II promoter, P:regulation of skeletal muscle tissue development, P:smooth muscle cell differentiation, P:transforming growth factor beta receptor signaling pathway, P:urogenital system development, P:heart development, P:protein phosphorylation, C:membrane, F:transforming growth factor beta-activated receptor activity, P:transmembrane receptor protein serine/threonine kinase signaling pathway, P:negative regulation of apoptotic process, P:signal transduction by phosphorylation
UniProt3D-structure, ATP-binding, Complete proteome, Disease mutation, Glycoprotein, Kinase, Magnesium, Manganese, Membrane, Metal-binding, Nucleotide-binding, Phosphoprotein, Polymorphism, Receptor, Reference proteome, Serine/threonine-protein kinase, Signal, Transferase, Transmembrane, Transmembrane helix
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceDiseaseP-valueDetectionPubMed/DOI
Exp21716316Homo sapiens4colon_rectumColorectal cancer (CRC) (CRC)0.00102whole genome-microarray21716316

Compile date 10-20-2017© .