MoCadb-logoMoCadb - Molecule ID A5695

geneACSL4, ACS4, FACL4
nameLong-chain-fatty-acid--CoA ligase 4
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACSL4_HUMANO60488ENSG000000683662182Hs.268785300157, 300194, 300387

Functions and classifications

GOC:endoplasmic reticulum membrane, C:integral component of membrane, C:lipid particle, C:mitochondrial outer membrane, C:neuronal cell body, C:peroxisomal membrane, F:arachidonate-CoA ligase activity, F:ATP binding, F:long-chain fatty acid-CoA ligase activity, F:very long-chain fatty acid-CoA ligase activity, P:dendritic spine development, P:embryonic process involved in female pregnancy, P:fatty acid transport, P:lipid biosynthetic process, P:long-chain fatty-acyl-CoA biosynthetic process, P:negative regulation of prostaglandin secretion, P:positive regulation of cell growth, P:response to interleukin-15, P:response to nutrient, P:triglyceride biosynthetic process, F:catalytic activity, C:mitochondrial membrane, C:peroxisome, P:long-chain fatty acid metabolic process, P:triglyceride metabolic process, F:ligase activity, C:integral to membrane, C:endoplasmic reticulum
UniProtAlport syndrome, Alternative splicing, ATP-binding, Complete proteome, Deafness, Disease mutation, Elliptocytosis, Endoplasmic reticulum, Fatty acid metabolism, Hereditary hemolytic anemia, Ligase, Lipid metabolism, Magnesium, Membrane, Mental retardation, Microsome, Mitochondrion, Mitochondrion outer membrane, Nucleotide-binding, Peroxisome, Polymorphism, Reference proteome, Signal-anchor, Transmembrane, Transmembrane helix
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceDiseaseP-valueDetectionPubMed/DOI
Exp21716316Homo sapiens4colon_rectumColorectal cancer (CRC) (CRC)0.000303whole genome-microarray21716316
Exp26245529aHomo sapiens26colon_rectumAdenoma (Adenoma)0.047927899LC-MS/MS26245529
Exp26245529bHomo sapiens26colon_rectumColorectal cancer (CRC) (CRC)3.22E-09LC-MS/MS26245529
Exp26245529cHomo sapiens8colon_rectumColorectal cancer (CRC) (CRC)2.17E-05LC-MS/MS26245529

Compile date 10-20-2017© .