MoCadb-logoMoCadb - Molecule ID A5670

geneACO1, IRP1, IREB1
nameIron-responsive element binding protein 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACOC_HUMANP21399ENSG0000012272948Hs.567229100880

Functions and classifications

GOC:cytosol, C:endoplasmic reticulum, C:Golgi apparatus, C:mitochondrion, F:4 iron, 4 sulfur cluster binding, F:aconitate hydratase activity, F:iron-responsive element binding, F:metal ion binding, P:cellular iron ion homeostasis, P:citrate metabolic process, P:intestinal absorption, P:post-embryonic development, P:regulation of translation, P:response to iron(II) ion, P:tricarboxylic acid cycle, P:metabolic process, P:regulation of translation, F:4 iron, 4 sulfur cluster binding, P:metabolic process, F:citrate hydro-lyase (cis-aconitate-forming) activity, F:isocitrate hydro-lyase (cis-aconitate-forming) activity, F:mRNA 5'-UTR binding
UniProt3D-structure, 4Fe-4S, Complete proteome, Cytoplasm, Direct protein sequencing, Iron, Iron-sulfur, Lyase, Metal-binding, Polymorphism, Reference proteome, RNA-binding, Tricarboxylic acid cycle
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp26175278aHomo sapiens16colon_rectumCRC (Stage II) (CRC)1.17364033<0.05LC-MS/MS26175278
Exp26175278bHomo sapiens10colon_rectumCRC (Stage IIIA) (CRC)1.565024972<0.05LC-MS/MS26175278
Exp26175278cHomo sapiens14colon_rectumCRC (Stage IIIB) (CRC)1.565024972<0.05LC-MS/MS26175278
Exp26175278dHomo sapiens17colon_rectumCRC (Stage IIIC) (CRC)1.30955565<0.05LC-MS/MS26175278
Exp26245529aHomo sapiens26colon_rectumAdenoma (Adenoma) 0.044868601LC-MS/MS26245529

Compile date 10-20-2017© .