MoCadb-logoMoCadb - Molecule ID A2341

geneACTN1
nameAlpha-actinin 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACTN1_HUMANP12814ENSG0000007211087Hs.509765102575, 615193

Functions and classifications

GOC:cytoskeleton, C:cytosol, C:dendritic spine, C:extracellular vesicular exosome, C:fascia adherens, C:focal adhesion, C:nucleus, C:plasma membrane, C:platelet alpha granule lumen, C:pseudopodium, C:ruffle, C:Z disc, F:calcium ion binding, F:double-stranded RNA binding, F:integrin binding, P:actin filament bundle assembly, P:extracellular matrix organization, P:focal adhesion assembly, P:negative regulation of cellular component movement, P:platelet activation, P:platelet degranulation, P:regulation of apoptotic process, C:cortical actin cytoskeleton, C:stress fiber, P:actin crosslink formation
UniProt3D-structure, Acetylation, Actin-binding, Alternative splicing, Calcium, Cell junction, Cell membrane, Cell projection, Complete proteome, Cytoplasm, Cytoskeleton, Direct protein sequencing, Disease mutation, Membrane, Metal-binding, Phosphoprotein, Polymorphism, Reference proteome, Repeat
PADBCS: Cell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21716316Homo sapiens4colon_rectum Colorectal cancer (CRC) (CRC) 0.0059whole genome-microarray21716316
Exp26175278aHomo sapiens16colon_rectum CRC (Stage II) (CRC)0.553836147<0.05LC-MS/MS26175278
Exp26175278bHomo sapiens10colon_rectum CRC (Stage IIIA) (CRC)0.378425529<0.05LC-MS/MS26175278
Exp26175278cHomo sapiens14colon_rectum CRC (Stage IIIB) (CRC)0.378425529<0.05LC-MS/MS26175278
Exp26175278dHomo sapiens17colon_rectum CRC (Stage IIIC) (CRC)1.299941659<0.05LC-MS/MS26175278
Exp26245529aHomo sapiens26colon_rectum Adenoma (Adenoma) 0.003664714LC-MS/MS26245529
Exp26245529bHomo sapiens26colon_rectum Colorectal cancer (CRC) (CRC) 0.002224968LC-MS/MS26245529
Exp26861291aHomo sapiens20rectummicrodissected tissuenCRT I, Dworak 1 2 (poor responder) (CRC)n.r.<0.05LTQ-hybrid mass spectrometer26861291
Exp26861291bHomo sapiens20rectummicrodissected tissuenCRT II, Dworak 1 2 (poor responder) (CRC)0.52<0.05LTQ-hybrid mass spectrometer26861291
Exp27468721Homo sapiens10colon_rectum Colorectal cancer (CRC) (CRC) <0.05LC-MS/MS27468721

Compile date 10-20-2017© .