MoCadb-logoMoCadb - Molecule ID A1177

geneA2M, CPAMD5, FWP007
nameAlpha-2-macroglobulin precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
A2MG_HUMANP01023ENSG000001758992Hs.212838103950

Functions and classifications

GOC:cytosol, C:extracellular space, C:extracellular vesicular exosome, C:platelet alpha granule lumen, F:interleukin-1 binding, F:serine-type endopeptidase inhibitor activity, F:tumor necrosis factor binding, P:blood coagulation, intrinsic pathway, P:negative regulation of complement activation, lectin pathway, P:platelet activation, P:platelet degranulation, P:regulation of small GTPase mediated signal transduction, P:small GTPase mediated signal transduction, P:stem cell differentiation, F:endopeptidase inhibitor activity, P:negative regulation of endopeptidase activity, P:stem cell differentiation
UniProt3D-structure, Bait region, Complete proteome, Direct protein sequencing, Disulfide bond, Glycoprotein, Isopeptide bond, Polymorphism, Protease inhibitor, Reference proteome, Secreted, Serine protease inhibitor, Signal, Thioester bond
PADBINH: inhibitor (protease, kinase, other enzymes, pathways)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionValidationPubMed/DOI
Exp22395091bHomo sapiens60bloodserumColorectal cancer (CRC) (CRC)DOWN<0.05MS/MSELISA22395091
Exp26054784Homo sapiens8colon_rectum CRC tumor (CRC)0.2377950.045392985Nano-LC–MS/MS 26054784
Exp26175278aHomo sapiens16colon_rectum CRC (Stage II) (CRC)0.1805664<0.05LC-MS/MS 26175278
Exp26175278bHomo sapiens10colon_rectum CRC (Stage IIIA) (CRC)1.334784627<0.05LC-MS/MS 26175278
Exp26175278cHomo sapiens14colon_rectum CRC (Stage IIIB) (CRC)1.334784627<0.05LC-MS/MS 26175278
Exp26175278dHomo sapiens17colon_rectum CRC (Stage IIIC) (CRC)0.853452285<0.05LC-MS/MS 26175278

Compile date 10-20-2017© .