MoCadb-logoMoCadb - Molecule ID A0772

geneEIF2AK2, PKR, PRKR
nameEukaryotic translation initiation factor 2-alpha kinase 2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
E2AK2_HUMANP19525ENSG000000553325610Hs.131431176871

Functions and classifications

GOC:cytosol, C:nucleus, C:perinuclear region of cytoplasm, F:ATP binding, F:double-stranded RNA binding, F:eukaryotic translation initiation factor 2alpha kinase activity, F:non-membrane spanning protein tyrosine kinase activity, F:protein phosphatase type 2A regulator activity, P:activation of MAPKK activity, P:defense response to virus, P:endoplasmic reticulum unfolded protein response, P:evasion or tolerance by virus of host immune response, P:innate immune response, P:modulation by virus of host process, P:negative regulation of osteoblast proliferation, P:negative regulation of translation, P:negative regulation of viral genome replication, P:peptidyl-tyrosine phosphorylation, P:positive regulation of chemokine production, P:positive regulation of NF-kappaB transcription factor activity, P:positive regulation of NIK/NF-kappaB signaling, P:positive regulation of stress-activated MAPK cascade, P:protein autophosphorylation, P:regulation of hematopoietic stem cell differentiation, P:regulation of hematopoietic stem cell proliferation, P:regulation of NLRP3 inflammasome complex assembly, P:response to interferon-alpha, P:response to virus, P:transcription, DNA-templated, P:translation, P:viral life cycle, F:protein kinase activity, F:protein serine/threonine kinase activity, P:modulation by virus of host cellular process, P:viral infectious cycle, P:virus-infected cell apoptotic process, C:intracellular
UniProt3D-structure, Acetylation, Alternative splicing, Antiviral defense, ATP-binding, Complete proteome, Cytoplasm, Direct protein sequencing, Host-virus interaction, Immunity, Innate immunity, Isopeptide bond, Kinase, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Repeat, RNA-binding, Serine/threonine-protein kinase, Transcription, Transcription regulation, Transferase, Tyrosine-protein kinase, Ubl conjugation
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceDiseaseP-valueDetectionPubMed/DOI
Exp26245529aHomo sapiens26colon_rectumAdenoma (Adenoma)0.03598271LC-MS/MS26245529
Exp26245529bHomo sapiens26colon_rectumColorectal cancer (CRC) (CRC)3.43E-08LC-MS/MS26245529
Exp26245529cHomo sapiens8colon_rectumColorectal cancer (CRC) (CRC)2.60E-06LC-MS/MS26245529

Compile date 10-20-2017© .