MoCadb-logoMoCadb - Molecule ID A0429

geneACO2
nameAconitate hydratase, mitochondrial precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACON_HUMANQ99798ENSG0000010041250Hs.643610100850, 614559

Functions and classifications

GOC:mitochondrial matrix, C:nucleus, F:3 iron, 4 sulfur cluster binding, F:4 iron, 4 sulfur cluster binding, F:aconitate hydratase activity, F:iron ion binding, P:cell death, P:citrate metabolic process, P:isocitrate metabolic process, P:tricarboxylic acid cycle, F:4 iron, 4 sulfur cluster binding, C:mitochondrion, F:citrate hydro-lyase (cis-aconitate-forming) activity, F:isocitrate hydro-lyase (cis-aconitate-forming) activity
UniProt4Fe-4S, Acetylation, Complete proteome, Direct protein sequencing, Disease mutation, Iron, Iron-sulfur, Isopeptide bond, Lyase, Metal-binding, Mitochondrion, Neurodegeneration, Phosphoprotein, Polymorphism, Pyrrolidone carboxylic acid, Reference proteome, Transit peptide, Tricarboxylic acid cycle, Ubl conjugation
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp24687888aHomo sapiens33polyp_and_tumormembrane FractionsCRC without metastasis (CRC)0.498876090.008727044LC-MS/MS24687888
Exp26175278aHomo sapiens16colon_rectum CRC (Stage II) (CRC)0.999931236<0.05LC-MS/MS26175278
Exp26175278bHomo sapiens10colon_rectum CRC (Stage IIIA) (CRC)1.461976329<0.05LC-MS/MS26175278
Exp26175278cHomo sapiens14colon_rectum CRC (Stage IIIB) (CRC)1.461976329<0.05LC-MS/MS26175278
Exp26175278dHomo sapiens17colon_rectum CRC (Stage IIIC) (CRC)2.119906664<0.05LC-MS/MS26175278
Exp26245529bHomo sapiens26colon_rectum Colorectal cancer (CRC) (CRC) 4.18E-09LC-MS/MS26245529
Exp26245529cHomo sapiens8colon_rectum Colorectal cancer (CRC) (CRC) 1.63E-05LC-MS/MS26245529

Compile date 10-20-2017© .