PADB-logoLSSR - dataset 16550189

PubMed ID16550189
AuthorsDecramer S, Wittke S, Mischak H, Zurbig P, Walden M, Bouissou F, Bascands JL, Schanstra JP.
TitlePredicting the clinical outcome of congenital unilateral ureteropelvic junction obstruction in newborn by urinary proteome analysis.
JournalNat Med. 2006 Apr;12(4):398-400. Epub 2006 Mar 19
AbstractWe analyzed urinary polypeptides from individuals with neonatal ureteropelvic junction (UPJ) obstruction to predict which individuals with this condition will evolve toward obstruction that needs surgical correction. We identified polypeptides that enabled diagnosis of the severity of obstruction and validated these biomarkers in urine collected in a prospective blinded study. Using these noninvasive biomarkers, we were able to predict, several months in advance and with 94% precision, the clinical evolution of neonates with UPJ obstruction.

SpeciesTissue / SourceSubcellDiseaseSample digestSeparationDetectionQuantification
humanurinewholeNeonatal ureteropelvic junction (UPJ) obstructionundigested CE-MS 

Identified molecules

Molecule IDReferenceGene/SymbolNameSource acc#Regulation in diseaseRatio (disease/control)Frequency % found in diseaseFrequency % found in healthyAssociated diseaseBiomarkerNID stats
A1512CO5A2_HUMAN preprocollagen type VNP_000384  7416  103m/z: 1147.56
A4702CO9A1_HUMANCOL9A1collagen type 9NP_001842  34100  103m/z: 1161.56

Compile date 12-23-2014© PADB initiative