PADB-logoLSSR - molecule cluster A8961PSMC5, SUG126S protease regulatory subunit 8

Molecule reference

organismSwissProtUniProtlength [aa]Mr [Da]OMIM
Homo sapiensPRS8_HUMANP6219540645626601681

Functions and Classifications

GOC:cytoplasmic vesicle, C:cytosol, C:cytosolic proteasome complex, C:inclusion body, C:nuclear proteasome complex, C:nucleoplasm, C:proteasome accessory complex, F:ATP binding, F:ATPase activity, F:transcription cofactor activity, P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, P:apoptotic process, P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, P:G1/S transition of mitotic cell cycle, P:mRNA metabolic process, P:negative regulation of apoptotic process, P:negative regulation of transcription, DNA-templated, P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, P:positive regulation of inclusion body assembly, P:positive regulation of transcription, DNA-templated, P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, P:protein polyubiquitination, P:regulation of cellular amino acid metabolic process, P:transcription from RNA polymerase II promoter, P:viral process, C:cytoplasm, C:proteasome complex, F:nucleoside-triphosphatase activity, P:protein catabolic process, P:M/G1 transition of mitotic cell cycle, P:negative regulation of programmed cell death, P:negative regulation of transcription, DNA-dependent, P:positive regulation of transcription, DNA-dependent, P:regulation of apoptotic process, P:S phase of mitotic cell cycle, P:viral reproduction", P:metabolic process
UniProt3D-structure, Acetylation, Alternative splicing, ATP-binding, Complete proteome, Cytoplasm, Nucleotide-binding, Nucleus, Polymorphism, Proteasome, Reference proteome
PADBENZ: enzyme, enzymatic properties

Expression

ratios [in mouse]
cytosol/nucleusheart/brainkidney/brainliver/brain
28   
percent [in mouse]
cerebrumcerebellumbrainstemspinal cordkidneyliverheartskeletal muscleadiposestomachsmall intestinelarge intestinetestisplacenta
0000000000000100

tissues and studies

study IDspeciestissuesubfractionsubcellular locationdiseaseassociated diseasebiomarkerregulation in diseaseratio (disease/control)frequency %study and detectID stats
18501002mousekidneycortexNucleushealthy     
16901338humantearwhole healthy     
18614015mousecerebrum; cerebellum; brainstem; spinal cord; kidney; liver; heart; skeletal muscle; adipose; stomach; small intestine; large intestine; testis; placentamitochondria healthy     
21616181mousecornea  lumican knock-out   1.215 
16861337humanblooderythrocytecytoplasmichealthy     
18536710drosohila (fruit fly)headPDZ-affinity peptide healthy     Identified peptides: 24
16899541ratkidneyinner medullary collecting duct (IMCD) Perfusion-biotinylation or incubation-biotinylation of IMCD     
16449382ratkidneyinner medullary collecting duct (IMCD) Flow through proteins from avidin affinity step of technique 4     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
17711322humankidneyglomerulus healthy     
16615899mouseliverorganelle healthy     
15684408mouseplasma membranebrain cortex and hippocampus healthy     
15064947humantestiswhole healthy     
15064947humantestiswhole healthy     
18582094mousetestiswhole healthy     
UNPUBLISHED_3humanPC3 cancer cellwhole        
18553995humanprostatewhole prostate cancer     Identified peptides: 6
19056867humanurineexosome healthy     Identified peptides: 1

Compile date 12-23-2014© PADB initiative